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New blood thinners aim to cut stroke risk with fewer bleeding side effects

NCT ID NCT07175428

Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 10 times

Summary

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Participants will receive one of the study drugs or apixaban, and researchers will monitor bleeding events and side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 1,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: 1. Has AF or flutter (paroxysmal or persistent), not felt to be secondary to a reversible cause, and an indication for indefinite anticoagulation treatment as described in the protocol 2. Meets one of the following: 1. CHA2DS2-VA \[C: Congestive heart failure; H: Hypertension; A2: Age ≥75 years (double points); D: Diabetes mellitus; S2: Stroke or TIA or Thromboembolism (double points); V: Vascular disease; A: Age 65-74 years\] score ≥2 and Oral Anticoagulant (OAC) naïve or 2. CHA2DS2-VA score ≥3 or 3. CHA2DS2-VA score of 2 and at least 1 enrichment criteria as described in the protocol 3. Must have an International Normalization Ratio (INR) \<2.5 at the time of randomization if taking warfarin or another Vitamin K Antagonist (VKA) Key Exclusion Criteria: 1. Has a mechanical heart valve prosthesis (Note: transcatheter aortic valve replacement is not an exclusion) 2. Has known moderate-to-severe mitral stenosis 3. Has had successful ablation therapy or Left Atrial Appendage (LAA) occlusion/exclusion, or planned ablation or LAA occlusion/exclusion as described in the protocol 4. Had an ischemic stroke within 2 days prior to randomization 5. Has estimated Glomerular Filtration Rate (eGFR) \<15 mL/min/1.73m\^2 within 30 days prior to randomization or on dialysis or expected to be started as described in the protocol 6. Has a history of central nervous system bleeding within 30 days prior to randomization Note: Other protocol-defined Inclusion/ Exclusion criteria apply

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Conditions

The condition(s) this trial relates to.

atrial fibrillation Hemorrhage stroke disorder thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation (AF)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    80 sites in 4 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AA Medical Research Center (MRC)

    RECRUITING

    Flint, Michigan, 48504, United States

  • Advanced Medical Research

    RECRUITING

    Maumee, Ohio, 43537, United States

  • Alpine Research TC

    RECRUITING

    Clinton, Utah, 84015, United States

  • Anderson Medical Research

    RECRUITING

    Ft. Washington, Maryland, 20744, United States

  • Beth Israel Lahey Health, Beth Israel Deaconess Medical Center (BIDMC)

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Blue Coast Research Center, LLC

    RECRUITING

    Indianapolis, Indiana, 46237, United States

  • CHU de Quebec-Universite Laval

    RECRUITING

    Québec, G1R 2J6, Canada

  • CISSS du Bas-Saint-Laurent - Hopital regional de Rimouski - Cardiologie

    RECRUITING

    Rimouski, Quebec, G5L 5T1, Canada

  • Cardiologia Assistencial e de Pesquisa Ltda (Cardresearch)

    RECRUITING

    Belo Horizonte, Minas Gerais, 30150-274, Brazil

  • Cardiology Associates Medical Group

    RECRUITING

    Ventura, California, 93003, United States

  • Cardiovascular Center of Sarasota Foundation for Research and Education

    RECRUITING

    Sarasota, Florida, 34239, United States

  • Centre Hospitalier Universitaire De Sherbrooke (CHUS) - Cardiologie

    RECRUITING

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Centro De Pesquisa Clinica Do Coracao

    RECRUITING

    Aracaju, Sergipe, 49055-530, Brazil

  • Centro de Estudos Procardio

    RECRUITING

    Blumenau, Santa Catarina, 89010-022, Brazil

  • Centro de Investigacion Clinica

    RECRUITING

    Ciudad Autonoma de Buenos Aires, Buenos Aires, 1060, Argentina

  • Centro de Investigaciones Clinicas del Litoral

    RECRUITING

    Santa Fe, S3000FWO, Argentina

  • Clinical Site Partners, LLC DBA Flourish Research

    RECRUITING

    Winter Park, Florida, 32789, United States

  • Complete Heart Care P.A.

    RECRUITING

    McKinney, Texas, 75071, United States

  • Diex Recherche Inc.

    RECRUITING

    Sherbrooke, Quebec, J1LOK3, Canada

  • Diex Recherche Trois-rivieres

    RECRUITING

    Trois-Rivières, Quebec, G9A 4P3, Canada

  • Dr James Cha

    RECRUITING

    Oshawa, Ontario, L1J 2K1, Canada

  • East Coast Institute for Research, Jefferson City

    RECRUITING

    Jefferson City, Tennessee, 37760, United States

  • Eastern Shore Research Institute

    RECRUITING

    Fairhope, Alabama, 36532, United States

  • Empire Clinical Research

    RECRUITING

    Pomona, California, 91767, United States

  • Faculdade de Medicina de Botucatu (UNESP)

    RECRUITING

    Botucatu, São Paulo, 18618-687, Brazil

  • Fairview Health Services

    RECRUITING

    Maplewood, Minnesota, 55109, United States

  • Franciscan Physician Network, Indiana Heart Physicians

    RECRUITING

    Indianapolis, Indiana, 46237, United States

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, Centro Integrado de Pesquisa (CIP)

    RECRUITING

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Fundacion Estudios Clinicos

    RECRUITING

    Rosario, Santa Fe Province, 2000, Argentina

  • GA Research Associates Ltd.

    RECRUITING

    Moncton, New Brunswick, E1G-1A7, Canada

  • Grady Health System

    RECRUITING

    Atlanta, Georgia, 30303, United States

  • Hamilton Health Sciences Corporation

    RECRUITING

    Hamilton, Ontario, L8L 2X2, Canada

  • Hamilton Medical Research Group (HMRG)

    RECRUITING

    Hamilton, Ontario, L8L 5G4, Canada

  • Health Sciences Research Building II

    WITHDRAWN

    Atlanta, Georgia, 30322, United States

  • Health sciences North - Cardiology

    RECRUITING

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • Heart Health Institute Research Inc. - Cardiology

    RECRUITING

    Scarborough Village, Ontario, M1B 4Z8, Canada

  • Hospital Ernesto Dornelles

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90160-092, Brazil

  • Hospital Maternidade e Pronto Socorro Santa Lucia

    RECRUITING

    Poços de Caldas, Minas Gerais, 37706-106, Brazil

  • Hospital Ruy Azeredo

    RECRUITING

    Goiânia, Goiás, 74453-200, Brazil

  • Hospital da Pontificia Universidade Catolica (PUC) Campinas

    RECRUITING

    Campinas, São Paulo, 13060-904, Brazil

  • Hospital das Clinicas da Universidade Federal de Goias

    RECRUITING

    Goiânia, Goiás, 74605-050, Brazil

  • Indiana Medical Research

    RECRUITING

    Merrillville, Indiana, 46410, United States

  • Indiana University

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Inpatient Research Clinic LLC

    RECRUITING

    Miami Lakes, Florida, 33014, United States

  • Instituto Dante Pazanese de Cardiologia

    RECRUITING

    São Paulo, 04012-909, Brazil

  • Instituto De Pesquisa Clinica de Campinas (Ipecc)

    RECRUITING

    Campinas, São Paulo, 13060-080, Brazil

  • Instituto de Cardiologia de Santa Catarina

    RECRUITING

    São José, Santa Catarina, 88103-450, Brazil

  • Interventional Cardiology Medical Group

    RECRUITING

    West Hills, California, 91307, United States

  • K&R Research LLC

    RECRUITING

    Marion, Ohio, 43302, United States

  • Mission Cardiovascular Research Institute

    RECRUITING

    Fremont, California, 94538, United States

  • Monroe Research, LLC

    RECRUITING

    West Monroe, Louisiana, 71291, United States

  • Monument Health Clinical Research

    RECRUITING

    Rapid City, South Dakota, 57701, United States

  • Moses Cone Hospital Operating Corporation dba Cone Health, Lebauer-Brodie Center for Cardiovascular Research

    RECRUITING

    Greensboro, North Carolina, 27401, United States

  • NSC Research, Inc

    RECRUITING

    Johns Creek, Georgia, 30024, United States

  • National Institute of California Heart and Vein Specialists

    RECRUITING

    Huntington Beach, California, 92648, United States

  • North Coast Cardiology

    RECRUITING

    Encinitas, California, 92024, United States

  • Northbay Clinical Research Center

    RECRUITING

    Santa Rosa, California, 95405, United States

  • Nouvelle Clinical Research LLC

    RECRUITING

    Cutler Bay, Florida, 33189, United States

  • Nucleo de Pesquisa Clínica SS

    RECRUITING

    Curitiba, Paraná, 80730-150, Brazil

  • Nucleo de Pesquisa do Hospital Cardiologico Costantini (NUPEC)

    RECRUITING

    Belo Horizonte, Minas Gerais, 30220-140, Brazil

  • Permian Research Foundation

    RECRUITING

    Odessa, Texas, 79761, United States

  • PharmaTex Research

    RECRUITING

    Amarillo, Texas, 79106, United States

  • Pontificia Universidade Catolica do Paraná (PUC) Trials

    RECRUITING

    Curitiba, Paraná, 80230-130, Brazil

  • Profound Research LLC at Southern California Heart Specialists

    RECRUITING

    Pasadena, California, 91105, United States

  • Profound Research, Millennium Cardiology

    RECRUITING

    Farmington Hills, Michigan, 48334, United States

  • Quanta Diagnostico por Imagem

    RECRUITING

    Curitiba, Paraná, 80045-110, Brazil

  • Reid Physician Associates

    RECRUITING

    Richmond, Indiana, 47374, United States

  • SEC Clinical Research

    RECRUITING

    Dothan, Alabama, 36305, United States

  • STAT Research Argentina

    RECRUITING

    Buenos Aires, 1060, Argentina

  • Sanatorio Duarte Quiros

    RECRUITING

    Córdoba, 5002, Argentina

  • Sociedade Hospitalar Angelina Caron

    RECRUITING

    Campina Grande do Sul, Paraná, 83430-973, Brazil

  • South Florida Research Organization LLC

    RECRUITING

    Medley, Florida, 33166, United States

  • Synergy Group Medical, LLC

    RECRUITING

    Missouri City, Texas, 77459, United States

  • Texas Institute of Cardiology PA

    RECRUITING

    McKinney, Texas, 75071, United States

  • The Cardiovascular Center

    RECRUITING

    Redding, California, 96001, United States

  • Tyler Cardiovascular Consultants

    RECRUITING

    Tyler, Texas, 75701, United States

  • University of Alberta Hospital - Cardiology

    RECRUITING

    Edmonton, Alberta, T6G 2G3, Canada

  • Valley Clinical Trials, Inc

    RECRUITING

    Covina, California, 91723, United States

  • Via Medica Research Center

    RECRUITING

    Goiânia, Goiás, 74223-130, Brazil

  • Viacar Recherches Cliniques Inc. - Cardiologie

    RECRUITING

    Longueuil, Quebec, J4H 4B9, Canada

  • Victoria Cardiac Arrhythmia Trials

    RECRUITING

    Victoria, British Columbia, V8Z 0B9, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.