Visual pathway disorder

About one in four children with seizures does not respond well to standard treatments. This study collects data from people whose doctors have prescribed the ketogenic diet, a high-fat, low-carbohydrate regimen, to see how it affects brain electrical activity and metabolism. Rese…

This study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure c…

This study tests an experimental drug called EPX-100 (clemizole) in 150 children and adults with Dravet syndrome, a severe form of epilepsy. The goal is to see if adding EPX-100 to current treatments can safely reduce the number of motor seizures. Participants will be randomly as…

This study follows 1,500 adults with focal-onset seizures who take eslicarbazepine as part of their normal care. Researchers track changes in seizure frequency, quality of life, and side effects over three months. Participants include people newly diagnosed and those switching fr…

This phase 3 study tests whether an investigational drug called RAP-219 can safely reduce the number of focal seizures in adults with epilepsy. About 312 participants will take either a low or medium dose of RAP-219 or a placebo pill daily. The main goal is to see if the drug low…

This study tests an experimental drug called RAP-219 in 333 adults with focal seizures (a type of epilepsy). The goal is to see if the drug safely reduces how often seizures happen compared to a placebo. Participants must be 18-75, have had focal epilepsy for at least 2 years, an…

This trial tests whether a structured home-based exercise and education program, added to standard care, can improve quality of life and reduce leg symptoms in adults with chronic venous insufficiency—a condition where leg veins struggle to return blood to the heart. Around 120 p…

This study looks at whether removing a brain tumor and the nearby area where seizures start can help people with tumor-related epilepsy. About 100 people aged 8 and older with brain tumors and seizures will have surgery and be followed for up to a year. The goal is to see if seiz…

This early-phase study tests the drug TURALIO (pexidartinib) in people aged 3 to 35 whose cancer has not responded to standard treatments. The goal is to find a safe dose and see if it can shrink tumors or control leukemia. Participants take a daily capsule for up to 2 years, wit…

This study tests whether the drug BHV-7000 can safely reduce seizures in adults with focal epilepsy that hasn't improved with other treatments. About 390 participants will receive either the drug or a placebo. The main goal is to see if the drug lowers the number of seizures per …

This study looks at two ways to treat Lennox-Gastaut syndrome (LGS), a severe form of childhood epilepsy: adding more anti-seizure medications or undergoing palliative surgery (like a vagus nerve stimulator or corpus callosotomy). Researchers will track thousands of children acro…

This study looks at what happens when people with epilepsy who have been seizure-free for at least two years stop one of their antiseizure medications. The goal is to see if coming off the drug improves quality of life and reduces side effects, without greatly increasing the risk…

This early-stage trial is testing whether a single oral dose of ayahuasca can reduce the frequency of psychogenic non-epileptic seizures (PNES) in adults aged 18 to 60. Participants must have PNES confirmed by video-EEG and will taper off psychiatric medications before the dose. …

This study tests a medicine called elsunersen in 40 children with a rare, severe form of epilepsy caused by changes in the SCN2A gene. The goal is to see if the drug can safely reduce how often seizures happen over 24 weeks. Children must have started having seizures before 3 mon…

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This program offers continued access to rufinamide for children with Lennox-Gastaut syndrome, a severe form of epilepsy, who completed a previous study. The goal is to keep providing the medication until it becomes commercially available in Poland. Only children who were already …

This study tests whether low intensity focused ultrasound (LIFU) — sound waves delivered through a wearable headband — can reduce seizures in adults with drug-resistant epilepsy. Participants wear the device during treatment sessions, and researchers track seizure frequency and b…

This study tests a one-time injection of lab-grown nerve cells (NRTX-1001) into the brain for people with a specific type of epilepsy that doesn't respond to medication. The cells are designed to release a calming chemical called GABA to quiet overactive brain signals. Researcher…

This study tests whether SPN-817 can reduce seizure frequency in adults with focal onset seizures that don't respond well to current medications. About 216 participants will receive either SPN-817 or a placebo, and researchers will track seizure changes over 14 weeks. The goal is…

This study tests whether a smartphone app called Medilepsy®, which uses artificial intelligence to personalize reminders, helps teens and young adults (ages 14-24) with epilepsy take their anti-seizure medicine more regularly. The study will enroll 200 underserved participants in…

This Phase 3 trial tests whether XEN1101 (azetukalner) can safely reduce seizure frequency in people with focal-onset seizures. About 360 adults whose seizures aren't controlled by current medications will receive either XEN1101 or a placebo added to their existing treatment. The…

This study tests a new drug called SPN-817 in 60 adults whose epilepsy does not improve with standard treatments. The main goal is to see if the drug is safe and tolerable. Researchers will also track whether it reduces the number of motor seizures. Participants take the drug as …

This pilot study tests a device called NaviFUS that uses low-intensity focused ultrasound to calm overactive brain areas. It involves 16 adults with drug-resistant epilepsy who still have frequent seizures despite trying at least three medications. The goal is to see if the treat…

This phase 3 trial tests whether brain tumor patients who have been seizure-free for 6 months on levetiracetam can safely stop the drug earlier than the standard 2-3 years. 604 adults with primary brain tumors and controlled seizures will be randomly assigned to stop levetiraceta…

This study tests the long-term safety of an experimental drug called RAP-219 in 30 adults whose focal seizures do not respond well to current treatments. Participants must have already completed a related earlier study. The goal is to see if RAP-219 remains safe and helps reduce …

This study tests the long-term safety and effectiveness of a drug called SPN-817 in adults with focal onset seizures (a type of epilepsy). About 100 people who completed a previous SPN-817 study will take the drug for one year. Researchers will track side effects and measure chan…

This study is tracking 300 adults with focal epilepsy whose seizures are not well controlled despite trying 2-3 other medications. Researchers are observing how well cenobamate works when added to their current treatment in real-world clinics across France, Germany, and Spain. Th…

This study is testing a small device that fits in the ear to detect seizures by measuring brain waves. Researchers will first test it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the in-ear device i…

This study is testing a wearable device that sits on the ears and uses sensors to detect and predict seizures in people with epilepsy. The device records brain, muscle, and eye activity, along with heart rate and skin signals. It will be compared to standard hospital EEG monitori…

This study tests whether showing cartoon video clips and using character voices during a visual field test can help children aged 5-8 stay focused and give more reliable results. Twenty children with certain eye conditions will be tested twice, once with the cartoon intervention …

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive standard care. The goa…

After a cardiac arrest, many survivors develop seizures that can worsen brain injury. This trial tests whether giving the drug perampanel soon after resuscitation can prevent those seizures. About 52 adults who are comatose after a cardiac arrest will receive either perampanel or…

This early-phase study tests whether a ketogenic (high-fat) diet can prevent epileptic spasms in infants with genetic epilepsy. Ten babies under 9 months old will receive the diet and be monitored with regular EEGs. The goal is to see if this approach is safe and feasible, potent…

This study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if se…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

Researchers at the University of Rochester are testing a home-based computer program that trains people to detect visual stimuli in their blind field. The trial enrolls adults who have lost part of their vision because of damage to the brain's visual cortex, often from a stroke. …

Researchers are testing a device called the Pedal Pump, which pumps both feet for 10 minutes to mobilize the body and improve lymphatic flow. The trial enrolls 30 hospitalized patients with lower extremity edema caused by heart failure, chronic venous insufficiency, kidney diseas…

This study tests a new cognitive behavioral therapy called ReACT for children aged 9-18 with psychogenic non-epileptic seizures (PNES) — episodes that look like seizures but have no physical cause. The therapy focuses on helping kids feel more in control and less afraid of their …

This trial tests whether a visual stimulation program using flickering black-and-white checkerboard patterns can improve visual function in children with low vision. The study includes children with mild to moderate low vision as well as those with severe or profound multiple dis…

This study tests a liquid form of cannabidiol (CBD) in 100 people aged 12 to 75 who have focal-onset seizures. CBD is already approved for certain rare seizure disorders, and researchers want to see if it can also help reduce focal seizures. Participants will take CBD oil by mout…

This program provides comprehensive low vision rehabilitation services to children aged 3 to 21 with vision impairment. Participants are prescribed optical devices and trained to use them, with the goal of improving their visual functioning and ability to read. The program aims t…

This study tests a web-based program called Epilepsy Journey, which includes online modules and telehealth sessions with a therapist, to help teens with epilepsy improve their executive functioning skills like planning, organization, and emotional control. 310 teens aged 13-17 wi…

This study tests a new type of talk therapy called ReACT for adults with functional seizures (also called psychogenic non-epileptic seizures). The therapy aims to help people regain control over their body by changing thoughts and behaviors that trigger seizures. Fifty participan…

This study tests whether 5 weekly sessions of eye exercises with real-time visual and audio feedback can improve how people with central vision loss use their peripheral vision. About 12 participants with bilateral central vision loss from macular degeneration will do saccadic an…

This study tests whether methylphenidate (Ritalin), a drug used for ADHD, can improve attention and memory in adults with epilepsy. 226 participants will be randomly assigned to take either the drug or a placebo for 8 weeks, then all can take the drug for another 8 weeks. The goa…

This pilot study tests whether a non-invasive headset that delivers mild electrical stimulation to nerves behind the ear can safely improve sleep in adults who are blind or severely sight impaired. Sixty participants will use the device for 30 minutes a day, five times a week for…

This study tests a new cognitive behavioral therapy called ReACT for teens aged 11-18 with psychogenic non-epileptic seizures (PNES) – episodes that look like seizures but are not caused by epilepsy. The therapy focuses on helping teens regain a sense of control over their body a…

This study tests a behavioral therapy called ReACT for teens aged 11-18 with functional seizures (non-epileptic). The therapy involves 12 sessions with a therapist to help manage seizures. Researchers want to see if a larger study is possible by checking how many teens join, stic…

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This study compares two 8-week telephone support programs for 120 adults with epilepsy who have mild to moderate depression. One program teaches skills to manage depression, while the other offers group support. Researchers will track mood, quality of life, and seizures for a yea…

This study tests a hat that shines infrared light on the head for 30 minutes each day. The goal is to see if it can safely reduce seizures in people with drug-resistant epilepsy. Thirteen adults will try it for six months, and researchers will track seizure changes and comfort.

This study aims to see if a common vein treatment called radiofrequency ablation is safe and helpful for people aged 80 and older with severe chronic venous insufficiency. About 50 participants will receive the procedure and be followed for 6 months. The goal is to measure how we…

This study tests whether a gentle, non-invasive ultrasound treatment can reduce or stop seizure activity in people with a severe type of ongoing seizure called status epilepticus that hasn't improved with standard medications. Ten participants in the ICU will receive a 10-minute …

This study tests a simpler way for paramedics to treat seizures in children. Instead of calculating doses, paramedics will use age-based, pre-set doses of a seizure-stopping medicine given as a shot or nasal spray. The goal is to see if this approach stops seizures before the chi…

This early-stage study is testing whether a contrast agent called mangafodipir can safely highlight areas where the blood-brain barrier is broken in people with drug-resistant epilepsy. Forty adults will undergo MRI scans with mangafodipir and gadolinium to see if these scans can…

This global study follows people with POLG-related disorders, a group of rare mitochondrial conditions, to understand how the disease progresses over time. By observing clinical changes in up to 300 participants of all ages, researchers aim to identify key milestones that could s…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use MRI scans to see which brain areas are damaged and how they respond to visual training. The goal is to better understand how the brain can adapt and restore some vision. About 1…

This study uses a virtual reality driving simulator to see how people with vision loss from a stroke steer a car. Researchers will compare driving accuracy between 40 participants with and without vision loss. The goal is to understand how the brain adapts to missing parts of the…

This study tests a smartphone-based tool called VisionWay that helps people with visual impairments choose the most accessible walking path before they start walking. Researchers will ask participants to walk different routes on a university campus and rate sidewalk features like…

This study aims to map the brain regions essential for language and cognition in people with epilepsy or brain tumors. Participants perform language-based tasks while their brain activity is recorded using fMRI or electrical stimulation. The goal is to compare brain organization …

This observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…

This study tracks the safety of Fycompa injection in people with epilepsy who have partial-onset seizures (age 4 and older) or primary generalized tonic-clonic seizures (age 12 and older). Researchers will record any side effects and measure drug levels in children aged 4 to 12. …

This study observes critically ill children in the ICU who are already undergoing continuous EEG monitoring to detect brain seizures. Researchers aim to identify which children are most at risk for seizures and evaluate the safety of current seizure management strategies. The goa…

This study aims to create a large database linking brain wave recordings (EEG) and medical records from up to 20,000 epilepsy patients at the University of New Mexico. By combining these two types of information, researchers hope to find patterns that predict seizures and improve…

This observational study will collect data from the medical records of 1,000 adults treated for status epilepticus (a prolonged seizure emergency) at two Swiss hospitals between 2005 and 2023. Researchers aim to learn how factors like early treatment, monitoring, and complication…

This study will create and test a team-based treatment program for people with Functional Neurological Disorder (FND), a condition that causes symptoms like seizures, dizziness, and tics without a clear physical cause. Researchers will enroll 1,100 adults and children at the Univ…

This study aims to create a North American registry of sudden unexplained death in epilepsy (SUDEP) cases. Researchers will interview family members and review medical records of people with epilepsy who died suddenly. By comparing these cases with living epilepsy patients, they …

This study screens children and adults aged 8 and older with known or suspected epilepsy, especially those whose seizures are not controlled by medication. Participants undergo tests like EEG, MRI, and PET scans to characterize their epilepsy. The goal is to find suitable candida…

This study tests whether a tiny device placed under the scalp can predict seizures in people with epilepsy that doesn't respond to medication. Twelve adults with focal epilepsy will wear the device and a smartwatch to track brain activity and other signals. The goal is to see if …

This study is collecting genetic information from 2,000 infants in China who had seizures before their first birthday. Researchers aim to find gene changes linked to seizures and see if personalized treatments can help control them better. The goal is to understand the genetic ca…

This study looks at whether people who have their first seizure after age 50 should be checked for stroke risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will screen 420 participants and track whether starting medications for these risks improve…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study looks at whether special vision training can improve how people with central vision loss from macular degeneration see and move their eyes. Researchers will train 60 adults aged 18 to 89 with severe vision loss to better detect and discriminate visual patterns. The goa…

This study observes 100 people with rare genetic neurodevelopmental disorders like Baker Gordon Syndrome and Syt-1 disorder. Researchers will track symptoms, collect genetic and imaging data, and create cell models to better understand these conditions. The goal is to improve dia…

This study is testing whether a special training program can help children with visual impairment learn better viewing strategies. The training involves six weeks of exercises that teach kids how to look in a structured way, zoom in and out, and tell objects apart. Researchers wi…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…

This study uses non-invasive brain stimulation (TMS or tDCS) to explore how the brain creates the intention to move. Researchers will compare healthy volunteers and people with psychogenic movement disorders or non-epileptic seizures. The goal is to better understand these condit…

This observational study looks at how bacteria in the gut and mouth are linked to epilepsy and whether they affect how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1,500 people with newly diagnosed epilepsy and healthy controls. By a…

This study looks at how older adults with and without vision problems step over obstacles of different heights and colors. Researchers want to understand how vision and eye movements affect walking to help prevent falls. About 200 adults who can walk on their own will take part.

This study follows 1,000 people who have certain genetic changes (hnRNP and others) that may cause developmental delays, autism, seizures, or muscle problems. Researchers collect medical records, school reports, and questionnaires to see how these gene variants affect behavior, t…

This study looks at what makes scuba divers more likely to suffer from oxygen toxicity, which can cause seizures. Researchers will test how breathing muscle training, lack of sleep, common medications, and carbon dioxide affect risk. About 62 healthy adults aged 18-45 will exerci…

This early-phase study investigates how scopolamine, a drug known to affect memory, changes brain activity in people with epilepsy who are already undergoing brain monitoring for seizures. Sixty participants will receive either scopolamine or a placebo and perform memory tasks wh…

This study from King's College London focuses on how to better identify early skin changes from chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, like using touch and …

This study looks at brain activity in 50 people with epilepsy who already need brain electrodes as part of their care. Researchers add tiny extra electrodes to record signals from single brain cells and brain waves. The goal is to understand what happens in the brain just before,…

This study from Mayo Clinic looks for genetic heart conditions in people with epilepsy that might raise the risk of sudden unexpected death (SUDEP). Researchers will analyze DNA from 600 adults aged 18-50 with epilepsy or related symptoms, plus their blood relatives. The goal is …

This large observational study is tracking 1,400 newborns in China who have seizures. Researchers will use EEG to record brain activity and follow the babies' development over time. The goal is to better understand how common newborn seizures are and how they affect long-term hea…