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Sound waves aimed at the brain could quiet seizures

NCT ID NCT07680842

Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study tests whether low intensity focused ultrasound (LIFU) — sound waves delivered through a wearable headband — can reduce seizures in adults with drug-resistant epilepsy. Participants wear the device during treatment sessions, and researchers track seizure frequency and brain activity using EEG and MRI. The goal is to see if this non-invasive approach can safely modulate brain networks linked to seizures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low Intensity Focused Ultrasound (LIFU) delivered via wearable device
What this could lead to
If successful, this could offer a non-invasive, drug-free option to reduce seizures in people with drug-resistant epilepsy.
What could go wrong
This is a small pilot study, so results may not apply broadly. The treatment may not reduce seizures for everyone, and side effects are still being explored.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Male or female between 21 and 65 years of age at screening * Clinical diagnosis of drug-resistant epilepsy with on average, 4 or more seizures per month. * Able to provide informed consent (or assent when applicable) by the subject or subject's legal representative. * Be willing to undergo a brain MRI. * Be able and willing to wear a headband during the treatment duration. * Be able to complete scheduled visits and daily seizure logs. Exclusion Criteria * Has a craniotomy or pathologic intracranial lesion (e.g. vascular malformations) in the trajectory of the focused ultrasound beam. * Pregnant, breastfeeding, is attempting pregnancy, or unwilling to practice birth control during participation in the study. * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. * Has any unstable medical or psychiatric disease. * Any contraindications for completing a brain MRI scan. * Has evidence of any other clinically relevant neurological disorder at the time of screening, including Alzheimer's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy epilepsy Epilepsy, Generalized focal epilepsy generalized epilepsy visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Drug resistant epilepsy Epilepsy Epilepsy (treatment refractory) Epilepsy comorbidities Epilepsy, drug resistant Epilepsy, focal Epilepsy, generalized

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94107, United States

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