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New epilepsy drug shows promise in reducing seizures

NCT ID NCT06132893

Disease control Sponsor: Biohaven Therapeutics Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 25, 2026 · Updated 2 times

Summary

This study tests whether the drug BHV-7000 can safely reduce seizures in adults with focal epilepsy that hasn't improved with other treatments. About 390 participants will receive either the drug or a placebo. The main goal is to see if the drug lowers the number of seizures per month.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 390 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: 1. Male and Female participants 18 to 75 years of age at time of consent. 2. Diagnosis of Focal Onset Epilepsy at least 1 year prior to screening visit defined by 2017 International League Against Epilepsy (ILAE) Classification and based on requirements of Epilepsy Adjudication criteria. a. Focal seizures i. Focal aware seizures with clinically observable signs and/or symptoms ii. Focal impaired awareness seizures iii. Focal to bilateral tonic-clonic seizures 3. Subject meets the 2009 ILAE definition of drug resistant epilepsy, failure of adequate trials of two tolerated and appropriately chosen and used anti-seizure medication (ASM) schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom. 4. Ability to keep accurate seizure diaries 5. Current treatment with at least 1 and up to 3 ASMs and 4 epilepsy treatments in total Key Exclusion Criteria: 1. History of status epilepticus (convulsive status epilepticus for \> 5 minutes or focal status epilepticus with impaired consciousness for \> 10 minutes) within the last 6 months prior to screening visit that is not consistent with the subject's habitual seizure. 2. History of repetitive/cluster seizures (where individual seizures cannot be counted) within the last 6 months prior to screening visit and during observation phase. 3. Resection neurosurgery for seizures \<4 months prior to the screening visit. 4. Radiosurgery performed \<2 years prior to the screening visit. 5. Subjects with only focal aware nonmotor seizures which involve subjective sensory or psychic phenomena only, without impairment of consciousness or awareness (formally called simple partial seizures), with or without ictal EEG correlation with clinical symptoms. 6. Any condition that would interfere with the subject's ability to comply with study instructions, place the subject at unacceptable risk, and/or confound the interpretation of safety or efficacy data from the study, as judged by the Investigator

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy epilepsy focal epilepsy visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Focal epilepsy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    101 sites in 12 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Poznaniu

    RECRUITING

    Poznan, Greater Poland Voivodeship, 60-702, Poland

  • Accellacare

    WITHDRAWN

    Ames, Iowa, 50010, United States

  • Accellacare

    WITHDRAWN

    Mooresville, North Carolina, 28117, United States

  • AdventHealth Orlando

    WITHDRAWN

    Orlando, Florida, 32804, United States

  • Augusta University

    RECRUITING

    Augusta, Georgia, 30912, United States

  • BCHP

    RECRUITING

    Hawthorne, New York, 10532, United States

  • BIOCINETIC Ltda

    RECRUITING

    Santiago, Región-MetropolitanadeSantiago, 8320000, Chile

  • Barrow Neurological Institute

    RECRUITING

    Phoenix, Arizona, 85013, United States

  • Bluegrass Epilepsy Research

    RECRUITING

    Lexington, Kentucky, 40504, United States

  • Budapesti Bajcsy-Zsilinszky Korhaz es Rendelointezet

    RECRUITING

    Budapest, 1106, Hungary

  • CHRU Nancy

    RECRUITING

    Nancy, Meurthe-et-Moselle, 54000, France

  • CHRU de Tours - Hôpital Bretonneau

    RECRUITING

    Tours, Indre-et-Loire, 37000, France

  • CHU Dijon Bourgogne

    RECRUITING

    Dijon, Côte-d'Or, 21000, France

  • CHU UCL Namur - Site Godinne

    RECRUITING

    Yvoir, Namur, 5530, Belgium

  • CHU de Lille - Hopital Claude Huriez

    COMPLETED

    Lille, Nord, 59037, France

  • CHU de Montpellier- Hôpital Gui De Chauliac

    RECRUITING

    Montpellier, Hérault, 34295, France

  • CHU de Strasbourg - Hôpital de Hautepierre

    NOT_YET_RECRUITING

    Strasbourg, Bas-Rhin, 67000, France

  • CHU de Toulouse-Hôpital Pierre-Paul Riquet-Site de Purpan

    RECRUITING

    Toulouse, Haute-Garonne, 31059, France

  • Carilion Clinic

    RECRUITING

    Roanoke, Virginia, 24011, United States

  • Center for Neurosciences

    RECRUITING

    Tucson, Arizona, 85718, United States

  • Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno CEMIC-Elías Galván 4102

    RECRUITING

    Buenos Aires, Ciudad Autónoma de BuenosAires, C1431FWO, Argentina

  • Centro de Investigacion Clinica UC

    RECRUITING

    Santiago, Región-MetropolitanadeSantiago, 8320000, Chile

  • Centro de especialidades médicas Vanguardia

    RECRUITING

    Temuco, Araucania, 4780000, Chile

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    RECRUITING

    Gdansk, Pomeranian Voivodeship, 80-546, Poland

  • Christian Doppler-Klinik - Universitätsklinikum der PMU

    RECRUITING

    Salzburg, 5020, Austria

  • Clinical Best Solutions - Lublin

    RECRUITING

    Lublin, Lublin Voivodeship, 20-078, Poland

  • Clinical Hospital Center Rijeka - PPDS

    WITHDRAWN

    Rijeka, 51000, Croatia

  • Clinical Hospital Sveti duh

    WITHDRAWN

    Zagreb, City of Zagreb, 10000, Croatia

  • Clinical Research Solutions LLC

    WITHDRAWN

    Cypress, Texas, 77433, United States

  • Clinical Trials, Inc.

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • Cliniques Universitaires Saint-Luc

    RECRUITING

    Brussels, Brussels Capital, 1200, Belgium

  • Conci Carpinella - Santa Rosa N° 748

    RECRUITING

    Córdoba, X5008HHW, Argentina

  • Consultants in Epilepsy & Neurology, PLLC

    RECRUITING

    Boise, Idaho, 83702, United States

  • Copernicus Podmiot Leczniczy Sp. z o.o. - ul. Nowe Ogrody 1-6

    RECRUITING

    Gdansk, 80-803, Poland

  • Debreceni Egyetem Klinikai Kozpont Kenezy Gyula Campus

    RECRUITING

    Debrecen, Hajdú-Bihar, 4031, Hungary

  • Dent Neurosciences Research Center

    RECRUITING

    Amherst, New York, 14226, United States

  • EZR Research LLC

    COMPLETED

    Boca Raton, Florida, 33486, United States

  • Encore Medical Research of Weston LLC.

    RECRUITING

    Weston, Florida, 33331, United States

  • Fakultni nemocnice u sv. Anny v Brne

    RECRUITING

    Brno, South Moravian, 602 00, Czechia

  • Fakultni nemocnice v Motole

    RECRUITING

    Prague, Praha, Hlavní Mesto, 150 06, Czechia

  • Five Towns Neuroscience Research

    RECRUITING

    Woodmere, New York, 11598, United States

  • Floridian Research Institute

    WITHDRAWN

    Miami, Florida, 33179, United States

  • Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia - FLENI

    RECRUITING

    Buenos Aires, C1428AQK, Argentina

  • Groote Schuur Hospital

    WITHDRAWN

    Cape Town, Western Cape, 7700, South Africa

  • Hawaii Pacific Neuroscience

    RECRUITING

    Honolulu, Hawaii, 96817, United States

  • Henrico Doctors Neurology Associates, LLC

    RECRUITING

    Richmond, Virginia, 23235, United States

  • Hospices Civils de Lyon - 59 Bd Pinel

    RECRUITING

    Lyon, Rhône, 69003, France

  • Hospital Británico de Buenos Aires

    RECRUITING

    Buenos Aires, Ciudad Autónoma de BuenosAires, C1437JCH, Argentina

  • Hospital General de Agudos Dr. José María Ramos Mejia

    RECRUITING

    Balvanera, Ciudad Autónoma de BuenosAires, C1221ADC, Argentina

  • Hospital Italiano de Buenos Aires

    RECRUITING

    Buenos Aires, C1181ACH, Argentina

  • Hospital Padre Hurtado

    RECRUITING

    Santiago, Región-MetropolitanadeSantiago, 8260094, Chile

  • Hôpital Erasme

    RECRUITING

    Anderlecht, Brussels Capital, 1070, Belgium

  • Hôpital Pontchaillou

    RECRUITING

    Rennes, 35033, France

  • Icahn School of Medicine at Mt. Sinai

    WITHDRAWN

    New York, New York, 10029, United States

  • InnoMed Clinical Trial Centre

    WITHDRAWN

    Cape Town, Western Cape, 7530, South Africa

  • Inst of Neurology

    RECRUITING

    Livingston, New Jersey, 07039, United States

  • Instituto Neurologico Thalamus

    RECRUITING

    Viña del Mar, Valparaiso, 2520021, Chile

  • Instituto Privado Kremer

    RECRUITING

    Córdoba, X5004AOA, Argentina

  • Instytut Psychiatrii i Neurologii

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-957, Poland

  • Investigaciones Sanatorio Del Sur

    RECRUITING

    San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina

  • Javara

    COMPLETED

    Silver Spring, Maryland, 20901, United States

  • Kempenhaeghe - PPDS

    RECRUITING

    Heeze, North Brabant, 5591 VE, Netherlands

  • Kepler Universitätsklinikum Linz - Med Campus III

    RECRUITING

    Linz, Upper Austria, 4020, Austria

  • Klinicki bolnicki centar Sestre Milosrdnice - Vinogradska cesta 29

    WITHDRAWN

    Zagreb, City of Zagreb, 10000, Croatia

  • Klinik Lengg AG

    RECRUITING

    Zurich, Zürich (de), 8008, Switzerland

  • LANDA Specjalistyczne Gabinety Lekarskie

    RECRUITING

    Krakow, 31-156, Poland

  • MAESC

    RECRUITING

    Bethesda, Maryland, 20817, United States

  • MTZ Clinical Research Powered by PRATIA - PPDS

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-172, Poland

  • Medizinische Universitat Wien (Medical University of Vienna)

    RECRUITING

    Vienna, 1090, Austria

  • Medsol Clinical Research Center

    RECRUITING

    Port Charlotte, Florida, 33952, United States

  • Michael E. DeBakey VA Medical Center

    WITHDRAWN

    Houston, Texas, 77030, United States

  • Minnesota Epilepsy Group, P.A.

    RECRUITING

    Roseville, Minnesota, 55113, United States

  • NEREG

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • NZOZ IGNIS dr med. Alicja Lobinska

    RECRUITING

    Świdnik, Lublin Voivodeship, 21-040, Poland

  • NeuroScience Research Center

    RECRUITING

    Canton, Ohio, 44718, United States

  • Neurology Consultants of Dallas, PA

    RECRUITING

    Dallas, Texas, 75243, United States

  • Neurosphera SP. Z O.O

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-829, Poland

  • Northwell Health

    RECRUITING

    New York, New York, 10021, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Nova Clinical Research, LLC

    RECRUITING

    Bradenton, Florida, 34209, United States

  • Novo-Med Zielinski i wsp. Sp.J. - ul. Brynowska 44

    RECRUITING

    Katowice, 40-594, Poland

  • OSU

    RECRUITING

    Columbus, Ohio, 43214, United States

  • OnSite Clinical Solutions

    WITHDRAWN

    Charlotte, North Carolina, 28211, United States

  • Pediatrix Medical Group of Florida

    WITHDRAWN

    Winter Park, Florida, 32789, United States

  • Pratia MCM Kraków

    RECRUITING

    Krakow, 30-727, Poland

  • Profound Research LLC

    COMPLETED

    Pasadena, California, 91105, United States

  • Przychodnia VISTAMED

    WITHDRAWN

    Wroclaw, Lower Silesian Voivodeship, 53-149, Poland

  • Pécsi Tudományegyetem Klinikai Kozpont -Ret u.

    RECRUITING

    Pécs, Baranya, 7623, Hungary

  • Revive Research Institute, Inc.

    COMPLETED

    Elgin, Illinois, 60123, United States

  • Revive Research Institute, Inc.

    WITHDRAWN

    Rochester Hills, Michigan, 48307, United States

  • Road Runner Research, Ltd

    RECRUITING

    San Antonio, Texas, 78249, United States

  • SE INK Juhasz Pal Epilepszia Központ

    NOT_YET_RECRUITING

    Budapest, 1145, Hungary

  • STAT Research S.A.

    RECRUITING

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1013AAB, Argentina

  • Sanatorio de la Trinidad - Mitre

    RECRUITING

    Buenos Aires, C1039AAO, Argentina

  • Santa Familia PTG Lodz

    RECRUITING

    Lodz, Lódzkie, 90-302, Poland

  • Santos Research Center

    RECRUITING

    Tampa, Florida, 33615, United States

  • Stanford Health Care

    RECRUITING

    Palo Alto, California, 94304, United States

  • Stichting Epilepsie Instellingen Nederland - Dokter Denekampweg 20

    RECRUITING

    Zwolle, Overijssel, 8025 BV, Netherlands

  • Stichting Epilepsie Instellingen Nederland - Heemstede

    RECRUITING

    Heemstede, North Holland, 2103 SW, Netherlands

  • Stony Brook Medicine

    RECRUITING

    Stony Brook, New York, 11794, United States

  • Tarrant Neurology Consultants

    NOT_YET_RECRUITING

    Fort Worth, Texas, 76104, United States

  • Thomas Jefferson University

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Twoja Przychodnia Nowosolskie Centrum Medyczne sp. z o.o

    RECRUITING

    Nowa Sól, Lubusz Voivodeship, 67-100, Poland

  • UPMC

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

  • UT Health San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

  • UVM MC

    WITHDRAWN

    Burlington, Vermont, 05401, United States

  • UZ Antwerpen

    RECRUITING

    Edegem, Antwerpen, 2650, Belgium

  • UZ Gent

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • University Clinical Centre Maribor

    RECRUITING

    Maribor, 2000, Slovenia

  • University of California San Diego

    RECRUITING

    La Jolla, California, 92041, United States

  • University of California, Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

  • University of Cincinnati

    RECRUITING

    Cincinnati, Ohio, 45267, United States

  • University of Colorado Anschultz Medical Campus

    RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Florida (Jacksonville)

    RECRUITING

    Jacksonville, Florida, 32209, United States

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Utah

    RECRUITING

    Salt Lake City, Utah, 84132, United States

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • Universitätsklinikum St. Pölten

    RECRUITING

    Sankt Pölten, 3100, Austria

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • WRN

    WITHDRAWN

    Rogers, Arkansas, 72758, United States

  • Wake Forest Baptist

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Yale School of Medicine - Yale-New Haven Hospital

    RECRUITING

    New Haven, Connecticut, 06519, United States

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