No more math mistakes: new paramedic protocol aims to stop Kids' seizures faster
NCT ID NCT05121324
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a simpler way for paramedics to treat seizures in children. Instead of calculating doses, paramedics will use age-based, pre-set doses of a seizure-stopping medicine given as a shot or nasal spray. The goal is to see if this approach stops seizures before the child reaches the hospital, and if it is as safe as the current method. About 6,700 children will take part across 20 cities.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 6,700 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2022
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 months to 13 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Witnessed by the paramedic to be actively seizing, regardless of seizure type or duration; AND * Under the care of a paramedic; AND * Transported by an EMS agency participating in the study Exclusion Criteria: * A prior history of a benzodiazepine allergy; OR * Known or presumed pregnancy; OR * Severe growth restriction based on the paramedic's subjective assessment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
20 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Children's Hospital of Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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Mecklenburg EMS
RECRUITINGCharlotte, North Carolina, 28226, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Oregon Health and Sciences University
RECRUITINGPortland, Oregon, 97239, United States
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University at Buffalo
RECRUITINGBuffalo, New York, 14203, United States
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University of Arizona
RECRUITINGTucson, Arizona, 85724, United States
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University of California, Davis
RECRUITINGSacramento, California, 95817, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48105, United States
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University of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75235, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84108, United States
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University of Washington
RECRUITINGSeattle, Washington, 98104, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Epilepsy's hidden toll on the heart and lungs: a clue to sudden death?
- Brain wave battle: deeper suppression may halt post-arrest seizures
- Seizure drug may shield the brain after cardiac arrest — a trial puts it to the test
- Brain surgery meets brain science: probing how a memory-related chemical system influences cognition
- Sleep and seizures: new study probes why stroke triggers epilepsy in some patients