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No more math mistakes: new paramedic protocol aims to stop Kids' seizures faster

NCT ID NCT05121324

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a simpler way for paramedics to treat seizures in children. Instead of calculating doses, paramedics will use age-based, pre-set doses of a seizure-stopping medicine given as a shot or nasal spray. The goal is to see if this approach stops seizures before the child reaches the hospital, and if it is as safe as the current method. About 6,700 children will take part across 20 cities.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 6,700 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2022

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 months to 13 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Witnessed by the paramedic to be actively seizing, regardless of seizure type or duration; AND * Under the care of a paramedic; AND * Transported by an EMS agency participating in the study Exclusion Criteria: * A prior history of a benzodiazepine allergy; OR * Known or presumed pregnancy; OR * Severe growth restriction based on the paramedic's subjective assessment

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    20 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baylor College of Medicine

    RECRUITING

    Houston, Texas, 77030, United States

  • Children's Hospital of Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

  • Children's National Hospital

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Indiana University

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Mecklenburg EMS

    RECRUITING

    Charlotte, North Carolina, 28226, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

  • Oregon Health and Sciences University

    RECRUITING

    Portland, Oregon, 97239, United States

  • University at Buffalo

    RECRUITING

    Buffalo, New York, 14203, United States

  • University of Arizona

    RECRUITING

    Tucson, Arizona, 85724, United States

  • University of California, Davis

    RECRUITING

    Sacramento, California, 95817, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

  • University of Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48105, United States

  • University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • University of Texas Southwestern

    RECRUITING

    Dallas, Texas, 75235, United States

  • University of Utah

    RECRUITING

    Salt Lake City, Utah, 84108, United States

  • University of Washington

    RECRUITING

    Seattle, Washington, 98104, United States

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