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Could a gum infection drug slow Alzheimer's? new trial launches

NCT ID NCT06847321

Disease control Sponsor: Lighthouse Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 13 times

Summary

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, and neither they nor their doctors know if they get the real drug or a placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
LHP588 (a drug targeting P. gingivalis bacteria)
What this could lead to
If it works, this could point toward a treatment that slows Alzheimer's progression in people with a specific bacterial infection.
What could go wrong
This is an early Phase 2 trial with only 300 participants. It may fail to show benefit, and targeting bacteria may not affect Alzheimer's symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * AD according to the National Institute on Aging-Alzheimer's Association criteria. * MMSE scores corresponding to mild and moderate AD. * Saliva rinse sample positive for P. gingivalis. * Plasma pTau217 above cutoff. * Subject and caregiver have provided full written informed consent. * Background symptomatic therapy with acetylcholinesterase inhibitors, and/or memantine, are allowed if the dose has been stable for 90 days and no changes are planned during the study. * Modified Hachinski score ≤4 at screening. Exclusion Criteria: * History of cancer requiring systemic therapy in last 5 years. * Evidence of a clinically significant, unstable cardiovascular, pulmonary, renal, hepatic, gastrointestinal, neurologic, or metabolic disease within 6 months prior to screening. * Unstable angina, uncompensated and/or symptomatic congestive heart failure (Grade 2 or higher on the New York Heart Association scale) or myocardial infarction within 6 months. * Acute or poorly controlled blood pressure \>180 mmHg systolic or \>100 mmHg diastolic at screening visit. * History or current evidence of major neurological or psychiatric illness such as schizophrenia, bipolar disorder, Parkinson's Disease, other. * Currently being treated with anti-amyloid beta antibodies or other disease-modifying treatments for dementia. * Other criteria in the Investigator's judgement that may interfere with the ability to participate in the study.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Alzheimer disease due to P. gingivalis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    37 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ATP Clinical Research, Inc.

    RECRUITING

    Orange, California, 92866, United States

  • Adams Clinic Harlem

    RECRUITING

    New York, New York, 10029, United States

  • Adams Clinical Boston

    RECRUITING

    Boston, Massachusetts, 02116, United States

  • Adams Clinical Watertown

    RECRUITING

    Watertown, Massachusetts, 02472, United States

  • Alzheimer's Disease Research Center

    RECRUITING

    Albany, New York, 12208, United States

    Contact Email: •••••@•••••

  • Alzheimer's Research and Treatment Center - Stuart

    RECRUITING

    Stuart, Florida, 34997, United States

    Contact Email: •••••@•••••

  • Alzheimer's Research and Treatment Center - Wellington

    RECRUITING

    Wellington, Florida, 33414, United States

    Contact Email: •••••@•••••

  • Anchor Neuroscience

    ACTIVE_NOT_RECRUITING

    Pensacola, Florida, 32502, United States

  • Ascension via Christi Research

    RECRUITING

    Wichita, Kansas, 67214, United States

  • Banner Alzheimer's Institute

    RECRUITING

    Phoenix, Arizona, 85006, United States

    Contact Email: •••••@•••••

  • Barrow Neurological Institute

    RECRUITING

    Phoenix, Arizona, 85013, United States

  • Brain Matters Research

    RECRUITING

    Delray Beach, Florida, 33445, United States

    Contact Email: •••••@•••••

  • CenExel Denver, CO

    RECRUITING

    Englewood, Colorado, 80113, United States

  • CenExel Research - Toms River

    RECRUITING

    Toms River, New Jersey, 08755, United States

  • CenExel Sherman Oaks

    RECRUITING

    Sherman Oaks, California, 91403, United States

  • Center for Advanced Research & Education Flourish-Gainesville

    RECRUITING

    Gainsville, Georgia, 30501, United States

  • Clinical Endpoints

    RECRUITING

    Scottsdale, Arizona, 85258, United States

  • Clinical Research Professionals - Headlands

    RECRUITING

    Chesterfield, Missouri, 63005, United States

  • Columbus Memory Center

    RECRUITING

    Columbus, Georgia, 31909, United States

    Contact Email: •••••@•••••

  • Conquest Research - Lake Nona

    RECRUITING

    Orlando, Florida, 32832, United States

  • Headlands PharmaSite

    RECRUITING

    Pikesville, Maryland, 21208, United States

  • Headlands Research-EMA

    RECRUITING

    Plymouth, Massachusetts, 02360, United States

  • IMA Evaluations

    RECRUITING

    Albuquerque, New Mexico, 87109, United States

  • JEM Research Institute

    RECRUITING

    Atlantis, Florida, 33462, United States

  • K2 Medical Research Nashville LLC

    RECRUITING

    Nashville, Tennessee, 37204, United States

  • Kerwin Research Center, LLC - Oak Cliff

    RECRUITING

    Dallas, Texas, 75216, United States

    Contact Email: •••••@•••••

  • Kerwin Research Center, LLC in Texas

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Email: •••••@•••••

  • NDx Clinical Research

    RECRUITING

    Dayton, Ohio, 45459, United States

    Contact Email: •••••@•••••

  • Neurological Research Center - Hattiesburg Clinic

    RECRUITING

    Hattiesburg, Mississippi, 39401, United States

  • Neuropsychiatric Research Center of Southwest Florida

    RECRUITING

    Fort Myers, Florida, 33912, United States

    Contact Email: •••••@•••••

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

    Contact Email: •••••@•••••

  • Oakland Clinical Research

    RECRUITING

    Oakland, California, 94609, United States

  • Progressive Medical Research

    RECRUITING

    Port Orange, Florida, 32127, United States

  • Re-Cognition Health Fairfax

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Riverside Clinical Research

    RECRUITING

    Riverside, California, 92506, United States

  • Summitt Research

    RECRUITING

    Portland, Oregon, 97210, United States

  • Tandem Clinical Research - Metairie

    RECRUITING

    Metairie, Louisiana, 70006, United States

  • University of Virginia Adult Neurology

    RECRUITING

    Charlottesville, Virginia, 22903, United States

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