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Detailed MRI scans could reveal which brain plaques trigger strokes

NCT ID NCT05897645

Knowledge-focused Sponsor: General Hospital of Shenyang Military Region Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers are building a large database of high-resolution MRI scans from stroke patients in China to study the fatty plaques inside brain arteries. The study enrolls adults who recently had an ischemic stroke and have a specific plaque in a major brain artery. By tracking these patients over time, the team aims to see whether certain plaque features on MRI predict future strokes or heart problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the imaging approach proves reliable, doctors could better predict which artery plaques are dangerous and tailor stroke prevention more precisely.
What could go wrong
This is an observational study, so it cannot prove that imaging changes outcomes. Results may not apply outside the Chinese population studied, and the follow-up period may be too short to capture all recurrences.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,110 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients with ischemic stroke who performed HRMRI

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Patient age ≥40 years * 2\. Time of stroke onset: within 2 week * 3\. Baseline NIHSS score ≤16 * 4\. Ischemic stroke confirmed by head CT or MRI * 5\. Premorbid mRS ≤1 * 6\. The degree of stenosis of extracranial arteries including internal carotid artery, vertebral artery on the lesion side ≤50% * 7\. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion * 8\. Signed informed consent Exclusion Criteria: * 1\. Intracranial hemorrhage found by head CT * 2\. Had a contraindication to MRI,or could not complete required MRI sequences * 3\. Intracranial tumor, arteriovenous malformation, or aneurysm * 4\. Comorbidity with any serious diseases and life expectancy is less than one year * 5\. Pregnancy * 6\. Patients not suitable for this clinical studies considered by researcher

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Conditions

The condition(s) this trial relates to.

intracranial arteriosclerosis ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

High resolution magnetic resonance imaging Intracranial atherosclerosis Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Neurology, General Hospital of Northern Theater Command

    RECRUITING

    Shenyang, 110016, China

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