New depression drug shows promise in early trial

NCT ID NCT07065240

Recruiting now Symptom relief Sponsor: Seaport Therapeutics Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 27 times

Summary

This study tests a new medicine called SPT-300 in 360 adults with major depression, with or without anxiety. Participants will receive either the drug or a placebo for 42 days to see if it reduces depression symptoms. The goal is to find a safer, more effective treatment option.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Seaport Investigator Site
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Chino, California, 91710, United States
Seaport Investigator Site
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Garden Grove, California, 92845-2506, United States
Seaport Investigator Site
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Glendale, California, 91206, United States
Seaport Investigator Site
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San Jose, California, 95124, United States
Seaport Investigator Site
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Cromwell, Connecticut, 06416, United States
Seaport Investigator Site
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Jacksonville, Florida, 32256, United States
Seaport Investigator Site
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Lauderhill, Florida, 33319, United States
Seaport Investigator Site
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Orlando, Florida, 32801, United States
Seaport Investigator Site
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Palm Bay, Florida, 32905, United States
Seaport Investigator Site
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West Palm Beach, Florida, 33407, United States
Seaport Investigator Site
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Atlanta, Georgia, 30328, United States
Seaport Investigator Site
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Decatur, Georgia, 30030, United States
Seaport Investigator Site
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Marietta, Georgia, 30060, United States
Seaport Investigator Site
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Boston, Massachusetts, 02116, United States
Seaport Investigator Site
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Boston, Massachusetts, 02131, United States
Seaport Investigator Site
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Russells Mills, Massachusetts, 02747, United States
Seaport Investigator Site
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St Louis, Missouri, 63141, United States
Seaport Investigator Site
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Brooklyn, New York, 11235, United States
Seaport Investigator Site
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Cedarhurst, New York, 11516, United States
Seaport Investigator Site
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New York, New York, 10029, United States
Seaport Investigator Site
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Staten Island, New York, 10314, United States
Seaport Investigator Site
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Independence, Ohio, 44131, United States
Seaport Investigator Site
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North Canton, Ohio, 44720, United States
Seaport Investigator Site
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Allentown, Pennsylvania, 18104, United States
Seaport Investigator Site
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Dallas, Texas, 75231, United States
Seaport Investigator Site
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Irving, Texas, 75062, United States
Seaport Investigator Site
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Richardson, Texas, 75080, United States
Seaport Investigator Site
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Everett, Washington, 98201, United States
Seaport Investigator Site
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Plovdiv, 4004, Bulgaria
Seaport Investigator Site
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Sofia, 1000, Bulgaria
Seaport Investigator Site
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Sofia, 1680, Bulgaria
Seaport Investigator Site
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Brno, 602 00, Czechia
Seaport Investigator Site
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Pilsen, 301 00, Czechia
Seaport Investigator Site
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Prague, 100 00, Czechia
Seaport Investigator Site
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Prague, 110 00, Czechia
Seaport Investigator Site
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Prague, 160 00, Czechia
Seaport Investigator Site
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Prague, 186 00, Czechia
Seaport Investigator Site
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Berlin, Brandenburg, D-10629, Germany
Seaport Investigator Site
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Schwerin, Mecklenburg-Vorpommern, 19053, Germany
Seaport Investigator Site
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Bad Homburg, 61348, Germany
Seaport Investigator Site
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Chemnitz, 09111, Germany
Seaport Investigator Site
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Budapest, 1033, Hungary
Seaport Investigator Site
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Budapest, 1083, Hungary
Seaport Investigator Site
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Budapest, 1134, Hungary
Seaport Investigator Site
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Bełchatów, 97-400, Poland
Seaport Investigator Site
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Bialystok, 15-404, Poland
Seaport Investigator Site
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Bialystok, 15-464, Poland
Seaport Investigator Site
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Bydgoszcz, 85-080, Poland
Seaport Investigator Site
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Gdansk, 80-438, Poland
Seaport Investigator Site
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Katowice, 40-600, Poland
Seaport Investigator Site
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Leszno, 64-100, Poland
Seaport Investigator Site
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Poznan, 60-744, Poland
Seaport Investigator Site
WITHDRAWN

Torun, 87-100, Poland
Seaport Investigator Site
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Tuszyn, 95-080, Poland
Seaport Investigator Site
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Warsaw, 00-124, Poland
Seaport Investigator Site
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Wroclaw, 54-617, Poland
Seaport Investigator Site
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Bratislava, 82007, Slovakia
Seaport Investigator Site
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Rimavská Sobota, 979 01, Slovakia
Seaport Investigator Site
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Vranov nad Topľou, 09301, Slovakia

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER (MDD) MAJOR DEPRESSIVE DISORDER WITH ANXIOUS DISTRESS