MAJOR DEPRESSIVE DISORDER (MDD)

This study is testing whether adding an experimental drug called SPN-821 to standard antidepressant medication helps adults with major depressive disorder. Researchers will enroll 230 participants who are currently taking antidepressants but still experiencing significant depress…

This study is testing whether a non-invasive brain stimulation treatment is safe and helpful for teenagers hospitalized with severe depression. Researchers will use a magnetic coil placed on the head to stimulate specific brain areas, comparing it to a fake (sham) treatment. The …

This study is testing a new drug called CYB003 to see if it helps reduce symptoms of major depression when added to a person's current antidepressant medication. It will involve 330 adults with moderate to severe depression who are already on a stable dose of antidepressants. Par…

This study is testing whether an experimental medication called DT-101 can help reduce symptoms of major depression in adults. About 300 participants will receive either DT-101 or a placebo (inactive substance) for 6 weeks, with neither patients nor doctors knowing which treatmen…

This study is testing whether a non-invasive brain stimulation device, used at home, can help people with major depression. About 440 adults with moderate to severe depression will either use the device along with their usual care or continue with usual care alone for 10 weeks. T…

This study aims to see if non-drug approaches like physical activity, brain training games, and dietary supplements can help people with depression. Researchers want to find out if these lifestyle changes can reduce depressive symptoms and also help prevent or slow down memory an…

This study is testing if using a non-invasive magnetic brain stimulator (TMS) right before electroconvulsive therapy (ECT) can make the ECT treatment work with less electrical energy. Researchers want to see if this combination helps people with severe, hard-to-treat depression g…

This study is testing whether a faster, 5-day schedule of non-invasive brain stimulation can help reduce depression in older adults (ages 60-85) who haven't gotten better with standard antidepressant medications. Researchers will use a magnetic coil placed on the head to stimulat…

This study is testing whether adding a new drug called milsaperidone to standard antidepressants helps people with major depression who aren't getting enough relief. It will involve 500 adults whose current depression treatment isn't working well enough. Researchers will compare …

This small pilot study is testing whether adding a structured exercise program before and during a brain stimulation treatment makes it work better for people with difficult-to-treat depression. Researchers will compare the effects of exercise plus brain stimulation against brain…

This study is testing if adding a low dose of aripiprazole to a common antidepressant helps people with depression who get stuck in loops of negative, repetitive thinking. 108 adults with depression will take either the antidepressant alone or the antidepressant plus aripiprazole…

This study is testing an investigational drug called SPT-300 to see if it can help reduce symptoms in adults with major depression, including those who also feel anxious. About 360 participants will be randomly assigned to receive either the real drug or a placebo (inactive subst…

This study is testing whether a type of gentle brain stimulation, called tDCS, can be safely done at home by people with depression that hasn't improved with standard treatments. Ten participants will self-administer the 20-minute stimulation sessions at home, five times a day fo…

This study is testing two new group talk therapies for major depression. One therapy focuses on changing rigid negative thoughts, while the other aims to boost motivation and enjoyment of positive experiences. Researchers will compare these new approaches to a waiting list to see…

This study is testing whether an experimental drug called ACP-211 can help adults with major depression who haven't gotten better with standard antidepressant treatments. Researchers will compare ACP-211 against a placebo (inactive pill) to see if it reduces depression symptoms m…

This study is testing a new monthly injection of a medication called cariprazine for people with schizophrenia, bipolar disorder, or major depression. It aims to see if the injection is safe, how the body processes it, and if it helps control symptoms. The study will enroll 24 ad…

This study is testing whether a fecal microbiota transplant (FMT) can help people with major depression who don't get better enough after starting a standard antidepressant. About 214 participants will take either FMT capsules or placebo pills for four weeks while continuing thei…

This study is testing whether a safe, non-invasive brain stimulation device can help treat major depression when used at home. For 10 weeks, 200 participants will use the device, with half receiving a fake version for comparison, all while being monitored remotely by video. The g…

This study is testing a new software called EMOCARE to see if it can reliably measure emotional states in people with depression, matching results from standard paper questionnaires. Over 100 adults with mild to severe depression will use the app on their phone or computer for 6 …

This study is testing a new, non-invasive tool to help detect early signs of cognitive decline. Researchers will use a VR headset with eye-tracking to measure how people's pupils respond during simple memory tasks. They aim to see if these pupil measurements can identify subtle c…

This study is testing whether lifestyle changes can help prevent memory and thinking problems in adults aged 50-80 who have depression or depressive symptoms. Participants will try different 12-week programs involving supervised exercise, brain training games, or Mediterranean di…

This small, early-stage study is testing whether a sleep medication called suvorexant is safe and tolerable for veterans with major depression and elevated suicide risk. Over four weeks, 30 participants will take the drug daily while researchers measure changes in suicidal though…

This study is testing a nasal spray containing a form of ketamine (called PRT-042) to see if it can quickly reduce severe depression symptoms and suicidal thoughts in adults. About 98 participants with major depressive disorder and current suicidal thoughts will receive either th…

This study is testing whether a home-based brain stimulation treatment can help reduce depression symptoms in people with borderline personality disorder (BPD). Sixty participants will use a device at home for 14 sessions over two weeks, with half receiving real treatment and hal…

This study is testing a new therapy that uses real-time brain scans to help people with depression. While inside an MRI machine, participants see their own brain activity and try to change negative thought patterns. Researchers want to see if this high-tech brain training can red…

This study tests whether a 5-day brain stimulation treatment called TMS can help reduce depression and suicidal thoughts in teens and young adults. The non-invasive treatment uses MRI scans to target specific brain areas and aims to provide a fast-acting alternative to traditiona…

This study is testing if adding a physical therapy program to standard depression treatment can improve quality of life for hospitalized adults. The program includes gentle exercises and education about physical activity's benefits for mental health. Researchers will also ask pat…

This large study in Pakistan is testing a flexible, three-step care plan to treat depression in women who have survived breast cancer. It will involve over 26,000 participants and compare the new plan to usual care to see if it better reduces depression and improves quality of li…

This study aims to understand how an online sleep improvement program helps reduce depression. Researchers will measure changes in a specific brain receptor and sleep patterns in 42 adults with depression before and after the therapy. The goal is to learn the biological reason wh…

This study is investigating whether a gentle, non-invasive stimulation of a nerve in the ear can improve motivation and mood in people with depression. Researchers will recruit 120 people, half with depression and half without, to see if the stimulation works and if a person's in…

This study aims to understand how depression affects different types of thinking, especially those related to emotions, in adults. Researchers will compare brain scans and thinking tests from 120 people with depression to 120 healthy volunteers. The goal is to map how depression …

This study aims to find objective biological markers in the brain to help diagnose and track treatment for severe mental disorders like depression, schizophrenia, and bipolar disorder. Researchers will use a powerful 7T MRI scanner and vision tests to compare brain chemistry and …

This study aims to see if using a visual life history calendar helps people in Hong Kong remember their mental health history more accurately. Researchers will compare the standard mental health interview with and without the calendar tool. The goal is to improve how we measure h…

This study uses special brain scans to understand how people with depression respond to magnetic stimulation therapy. Researchers will scan 100 adults—some receiving depression treatment and some healthy volunteers—to look for brain activity patterns. The goal is to gather resear…

This study aims to find biological signs in the brain and genes that can predict if a person's depression will return after they stop taking antidepressant medication. Researchers will follow 204 people with depression and healthy volunteers, measuring brain activity and taking b…

This study aims to better understand depression in teenagers by closely observing them. Researchers will track 1000 teens with moderate to severe depression using wearable devices, brain scans, and blood tests. The goal is to find patterns that could help predict how well treatme…