Major depressive disorder (MDD)
Clinical trials for Major depressive disorder (MDD) explained in plain language.
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New sleep aid trial targets lingering insomnia in depression
Symptom relief Stopped earlyThis study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase 2 • Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated Aug 01, 2026 00:00 UTC
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Depression drug trial halted early – what happened?
Symptom relief Stopped earlyThis study tested a new medicine called fosigotifator for adults with major depressive disorder. The goal was to see if it is safe and helps with depression symptoms. About 20 people were enrolled before the study was stopped early. Participants took either the drug or a placebo,…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase 1 • Sponsor: AbbVie • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Brain imaging may reveal who benefits from depression therapy
Knowledge-focused Stopped earlyThis study looks at brain activity in 100 adults with major depression who are receiving a treatment called accelerated TMS. Researchers use a special brain scanner (TD-fNIRS) to see if patterns of brain activity can predict who will respond well to the treatment. Healthy volunte…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Kernel • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Psychedelics rewire Brain's learning? yale study investigates
Knowledge-focused Stopped earlyThis observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC