MAJOR DEPRESSIVE DISORDER (MDD)

This study looked at whether adding lithium to personalized maintenance electroconvulsive therapy (ECT) can prevent depression relapse in people who already responded well to ECT. 96 adults with major depressive disorder were followed for 6 months. The goal was to find a better w…

This study tested a tool called acceXible that analyzes how people describe pictures to screen for and monitor major depression. Researchers looked for changes in speech that might signal depression. 166 adults with Spanish as their first language took part. The goal was to see i…

This study tested a non-invasive brain stimulation method called tDCS in 320 adults with depression, schizophrenia, OCD, anxiety, or insomnia. Participants received the stimulation while researchers measured symptom changes using standard rating scales. The goal was to see if tDC…

This study tested a new extended-release drug, levomilnacipran, for adults with major depression. 392 participants took either the new drug or an existing one (duloxetine) for 8 weeks. The goal was to see if the new drug works as well or better at reducing depression symptoms, me…

This study tested whether a combination of two drugs (dextromethorphan and bupropion) works better than standard antidepressants (SSRIs) for adults with major depression. 80 participants were randomly assigned to one of the two treatments for 6 weeks. The goal was to see how many…

This study tested a new medicine, NH102, for people with major depression. 243 adults took part to see if it helps reduce depression symptoms compared to a placebo or an existing drug (duloxetine). The goal is to find the right dose and check safety before moving to larger studie…

This study looked at whether adding magnesium supplements to standard depression treatment (fluoxetine) could improve thinking and memory. Forty adults with major depression took either fluoxetine alone or fluoxetine plus magnesium for six weeks. Researchers measured changes in c…

This study tested a new drug called ropanicant in 214 adults with major depression. Participants received one of two doses or a placebo for 6 weeks. The goal was to see if the drug reduces depression symptoms better than a placebo, using standard rating scales.

This study tested whether taking stingless bee honey daily for two months could improve depressive symptoms, memory, and brain health in adults with major depressive disorder. 45 participants either took the honey or nothing extra alongside their usual treatment. The goal was to …

This study explored whether a teen's family environment and cognitive abilities can predict how well they respond to a combination of brain stimulation (rTMS) and group therapy for depression. Researchers followed 163 adolescents with major depression to see which factors led to …

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check if the drug is safe and how the body processes it. Researchers measured side effects, vital signs, and mood chan…