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Study seeks to predict which teens benefit from brain stimulation and therapy

NCT ID NCT07283419

Knowledge-focused Sponsor: The First Hospital of Hebei Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 163 teens with major depression to see if family factors (like conflict or closeness) and cognitive skills (like attention and planning) could predict how well they respond to a combination of repetitive transcranial magnetic stimulation (rTMS) and group cognitive behavioral therapy. The goal was to identify early clues that might help personalize treatment. The study is complete and focused on gathering knowledge, not testing a new cure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) and group cognitive behavioral therapy
What this could lead to
If successful, this could help doctors personalize depression treatment for teens by identifying who will benefit most from combining rTMS with group therapy.
What could go wrong
This is a completed observational study, not a treatment trial, so it won't prove the therapy works—only which factors might predict response. Results may not apply to all teens with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

163 people

The number who actually took part.

Started

Aug 2023

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Inpatients aged 12 to 18 years recruited from the Department of Mental Health at The First Hospital of Hebei Medical University between August 2023 and July 2024. All participants had a primary diagnosis of Major Depressive Disorder (MDD) according to ICD-10 criteria and received a standardized combined intervention of rTMS and group therapy.

Ages

12 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Primary diagnosis of Major Depressive Disorder (MDD) according to ICD-10 criteria. * Score of ≥ 20 on the 24-item Hamilton Depression Rating Scale (HAMD-24). * Sufficient intellectual and linguistic ability to complete assessments and participate in therapy. * Provided written informed consent (participants and guardians). Exclusion Criteria: * Lifetime diagnosis of a psychotic or bipolar disorder. * Current substance use disorder. * Significant neurological illness (e.g., epilepsy) or metallic implants contraindicated for rTMS. * Receiving concurrent formal psychotherapy outside the study protocol.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adolescent depression Major depressive disorder (MDD)

Contacts and locations

Locations

  • The First Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.