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New pill combo challenges standard antidepressants in Head-to-Head trial

NCT ID NCT06957223

Symptom relief Sponsor: Asad Ullah Jan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a combination of dextromethorphan and bupropion works better than standard SSRI antidepressants for major depression. 80 adults with moderate to severe depression were randomly assigned to one of the two treatments for 6 weeks. Researchers measured changes in depression scores and remission rates to see which approach was more effective and tolerable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dextromethorphan-bupropion combination
What this could lead to
If this works, it could offer a new treatment option for people with major depression who don't respond well to standard SSRIs.
What could go wrong
This is a small, completed trial with only 80 participants and a short 6-week treatment period. Results may not apply to everyone, and the combination may have side effects like dizziness or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

May 2025

Finished

Dec 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Diagnosed with major depressive disorder (MDD) per DSM-5 criteria. Baseline depression score indicating moderate to severe depression Ability to provide informed consent Willing to comply with study requirements Exclusion Criteria: History of bipolar disorder, schizophrenia, or other psychotic disorders Current substance use disorder (within past 6 months) Active suicidal ideation requiring urgent intervention Pregnancy or breastfeeding Known hypersensitivity to study medications

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder (MDD)

Contacts and locations

Locations

  • Combined Military Hospital

    Nowshera, KPK, 25770, Pakistan

  • Department of Psychiatry, Combined Military Hospital Nowshera

    Nowshera, KPK, 25770, Pakistan

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