MAJOR DEPRESSIVE DISORDER (MDD)

This study tests whether an internet-based therapy program (ICBT) can help adults with generalized anxiety disorder or major depressive disorder. About 160 participants will either get their usual care or usual care plus an 8-week online course with 12 modules. The goal is to see…

This study tests whether combining ketamine infusions with dialectical behavioural therapy (DBT) can quickly reduce suicidal thoughts in people with treatment-resistant depression and borderline personality disorder. About 120 adults will receive either ketamine or a placebo alon…

This study tests whether a conversational AI that collects medical history can make people with depression feel more understood than standard care. About 130 adults with moderate to severe major depression will try both the AI and usual methods over 4 months. The goal is to see i…

This study tests a type of brain stimulation called theta burst stimulation (TBS) in 120 people with depression that hasn't improved with medication. Participants will receive either real or fake stimulation first, then everyone gets the real treatment. The goal is to see if TBS …

This study tests a new, drug-free approach for major depression. Participants do a computer task that uses eye-tracking to gently train their attention away from negative thoughts. The goal is to see if this can reduce depressive symptoms. The study involves 60 adults with depres…

This study tests whether adding a ketogenic (keto) diet to a personalized brain stimulation treatment can better reduce depression symptoms in adults whose depression hasn't improved with standard treatments. Sixty participants will follow either a keto diet or a standard healthy…

This study looks at whether adding a probiotic (Lactobacillus crispatus) to the antidepressant sertraline helps teens aged 12-18 with major depression feel better. Sixty participants will receive either the probiotic or a placebo with their medication for 8 weeks. The goal is to …

This early-stage study tests whether adding ketamine to talk therapy is safe and practical for people who struggle with both alcohol use disorder and major depression. Twenty participants will receive ketamine doses alongside cognitive behavioral therapy. The goal is to see if th…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and then be told either about th…

This study tests whether using a brain scan (MRI) to guide transcranial magnetic stimulation (TMS) works better than the standard scalp-measurement method for treating depression. About 160 adults with major depressive disorder will receive accelerated TMS (10 sessions daily for …

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The main goal is t…

This study tests whether inhaling DMT, a fast-acting psychedelic, can quickly reduce depression and suicidal thoughts. 140 adults with major depression will receive either a high or low dose, and those not better after a week can get an extra high dose. The goal is to see if DMT …

This study tests whether a special type of bright light therapy can improve thinking and memory problems in people with major depression. About 120 adults with depression and cognitive issues will either receive the special light or a dim red placebo light for four weeks. Researc…

This study follows 160 Hong Kong residents aged 18 to 70 to see if their daily rest-activity rhythms can predict who develops major depressive disorder. Participants wear a device to track sleep and movement and complete questionnaires over time. No treatment is given; the goal i…

This study looks at 130 adults with major depression and suicidal thoughts to understand how rapid treatments like Esketamine and electroconvulsive therapy (ECT) change the brain. Researchers will use brain scans, genetic tests, and blood samples to find markers that predict who …

This study looks at how ketamine might lower suicidal thoughts in people with major depressive disorder by targeting stress-related brain pathways. Researchers will use smartphone tracking and PET brain scans to understand the connection. The goal is to learn more about the biolo…

This early-phase study looks at how escitalopram (a common antidepressant) combined with memantine (a drug for Alzheimer's) affects memory and brain scans in 30 adults with major depression. Participants take escitalopram and either memantine or a placebo, then complete memory ta…

This study looks at how two treatments for severe depression—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—change brain activity. Researchers will use a special brain imaging technique (fNIRS) to measure blood flow in the front and side parts of the brain bef…

This study looks at how cognitive behavioral therapy (CBT) changes the brain in people aged 40-60 with major depression. Researchers will use MRI scans to measure brain structure, connections, and blood flow before and after CBT. The goal is to understand why some people improve …

This study tests whether a new selegiline skin patch causes less irritation or allergic reactions than an existing patch (EMSAM). About 230 healthy adults with major depressive disorder will wear both patches repeatedly. Researchers will check skin redness, swelling, and how well…

This study looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. Researchers will use brain scans and cognitive tests to build models that could help diagnose these conditions and predict treatment …

This study looks at how things like air pollution, noise, and lack of green spaces in cities may affect mental health. Researchers will track 680 people with depression, anxiety, or alcohol use disorder, plus healthy volunteers, using wearable devices and a smartphone app. The go…