Major depressive disorder (MDD)

This Phase 3 trial is testing whether adding lurasidone—a medication typically used for other mental health conditions—can help adults with major depressive disorder who haven't improved enough on an antidepressant alone. Participants will keep taking their current antidepressant…

Researchers at Yale are studying whether a prescription app called Rejoyn, which provides cognitive behavioral therapy exercises, can be a useful addition to standard depression treatments like TMS or esketamine. The study will enroll 50 adults with major depressive disorder who …

This trial tests whether transcranial magnetic stimulation (TMS) aimed at a brain circuit linked to the subgenual anterior cingulate cortex can reduce depression symptoms. Adults with major depressive disorder or persistent depressive disorder will receive either active or sham T…

This pilot study tests whether a structured care program called CARIBOU can reduce depressive symptoms in adolescents aged 15 to 18 with major depression. The program combines cognitive behavioral therapy, caregiver support, and medication management when needed, all coordinated …

This trial tests whether adding behavioral activation therapy to intravenous ketamine helps people with treatment-resistant depression more than ketamine alone. Adults aged 18 to 65 who have not improved with at least two antidepressants will receive ketamine infusions twice week…

This trial tests a web-based tool called PRADA that uses a person's genetics, symptoms, and preferences to help choose an antidepressant. Researchers will compare it to an older tool in adults with major depression across Ethiopia, Pakistan, and the UK. The goal is to see if the …

Researchers at Massachusetts General Hospital are testing whether daily oral thiamine, also known as vitamin B1, can reduce depression symptoms in children and adolescents aged 8 to 17.5 with major depressive disorder. Participants take a 100 mg thiamine capsule daily for 4 weeks…

This trial tests whether pregnenolone, a natural hormone, can help adults with both alcohol use disorder and major depression. Participants take either pregnenolone or a placebo for 12 weeks, while researchers track drinking, cravings, and mood. Brain scans will also look at how …

This trial tests whether a personalized, context-guided form of brain stimulation works better than the standard approach for adults with major depressive disorder. Participants receive either standard intermittent theta burst stimulation (iTBS) or a version where the stimulation…

This clinical trial is testing an experimental oral medication called KH607 in adults with major depressive disorder. Participants will receive either KH607 or a placebo once daily for several weeks, and researchers will measure changes in depression severity using a standard rat…

This clinical trial is testing an investigational drug called KH607 in adults with major depressive disorder (MDD). The study compares KH607 against an existing antidepressant, vortioxetine, to see which is more effective at reducing depression symptoms. Participants will take ei…

This trial tests whether a probiotic called IBNI617 can reduce depression symptoms in adults with moderate to severe major depressive disorder. Participants take either the probiotic or a placebo capsule twice daily for 8 weeks. The study measures changes in depression scores and…

This trial tests whether the schedule of maintenance transcranial magnetic stimulation (rTMS) affects the risk of depression relapse. Adults who responded to an initial course of theta burst stimulation are randomly assigned to receive 20 maintenance sessions either clustered tog…

This study tests a small, programmable device implanted in the skull that stimulates the brain's left frontal area to treat depression that hasn't improved with multiple medications. Ten adults with major depressive disorder will receive the implant and be monitored for safety an…

This trial investigates whether pregnenolone, a natural neurosteroid, can help adults who struggle with both cannabis use disorder and major depression. The study involves a small group of 20 participants aged 18 to 50 who use cannabis frequently and want to cut back. Researchers…

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

Researchers are testing a noninvasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in adults with major depressive disorder. The trial randomly assigns 60 participants to receive either active stimulation targeting the amygdala or a sha…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

This clinical trial is testing a non-invasive brain stimulation method called temporal interference transcranial alternating current stimulation (TI-tACS) for people with major depressive disorder or generalized anxiety disorder. The device uses two high-frequency electrical curr…

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This study tests a new non-invasive brain stimulation tool called kTMP to treat anhedonia, the loss of interest or pleasure, in people with major depressive disorder. 104 participants will receive either active or sham stimulation. The main goal is to see if kTMP changes brain ac…

This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The g…

This study looks at whether aerobic exercise (like brisk walking) and mindful breathing can help adults with major depressive disorder feel better and improve their quality of life. Participants are split into three groups: one does 45 minutes of moderate exercise three times a w…

This study tests a non-invasive brain stimulation technique called tTIS for adults with major depressive disorder. Sixty participants will receive either active stimulation targeting specific brain areas or a sham (fake) treatment over 5 days. Researchers will measure changes in …

This study tests a type of brain stimulation called theta burst stimulation (TBS) for people with depression that hasn't improved with medication. About 120 adults and teens will either get real TBS or a fake version first, then real TBS later. Researchers will measure changes in…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The…

This study tests a new computer task that trains your eye movements to help treat major depression. The task uses a gaze-contingent feedback system to retrain attention patterns. Researchers will enroll 60 adults with depression to see if this approach reduces symptoms. The goal …

This study tests whether an 8-week internet-based cognitive behavioral therapy (ICBT) program can help adults with generalized anxiety disorder or major depressive disorder. Participants in Taiwan will either receive standard care alone or standard care plus the online program, w…

This study investigates whether certain chemicals in the blood, called kynurenine metabolites, are linked to depressive disorders. Researchers will compare 45 people with depression to 45 healthy individuals, all aged 18 to 60. Participants will undergo psychological assessments …

This study aims to develop models that combine clinical assessments with biological data (multi-omics) to improve diagnosis of major depressive disorder and predict how patients will respond to antidepressants. Researchers will follow 150 participants aged 14-45 with depression, …

This study looks at how ketamine, a drug already used for depression, might reduce suicidal thoughts by affecting stress-related brain pathways. Researchers will give 12 adults with major depressive disorder a single ketamine infusion, then use smartphone tracking and PET brain s…

This pilot study will examine whether certain genes related to serotonin are linked to gut bacteria that process tryptophan in adults with depression, anxiety, PTSD, or panic disorder. Thirty participants will provide saliva and stool samples from home. The goal is to gather info…

This study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the …

This study looks at 130 people with major depression who have suicidal thoughts. Researchers will use brain scans, genetic tests, and other biological measures to see how rapid treatments like Esketamine and electroconvulsive therapy (ECT) change the brain. The goal is to find ea…

This research looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. The goal is to use brain imaging to better assess cognitive issues, improve diagnosis, and predict how well treatments might work.…

This study will use brain scans to see how cognitive behavioural therapy (CBT) affects the brains of 30 people aged 40-60 with major depression. Participants will receive 12 weeks of CBT, with follow-ups up to 9 months. The goal is to understand how CBT improves mood and thinking…

This study follows 160 adults in Hong Kong over time to see if disruptions in daily activity and sleep (rest-activity rhythms) can predict who develops major depressive disorder. Participants will wear activity monitors and complete questionnaires about mood and sleep. The goal i…