Brain scans reveal Ketamine's secret against suicidal thoughts?
NCT ID NCT07139106
First seen Nov 01, 2025
Summary
This study looks at how ketamine, a drug already used for depression, might reduce suicidal thoughts by affecting stress-related brain pathways. Researchers will give 12 adults with major depressive disorder a single ketamine infusion, then use smartphone tracking and PET brain scans to monitor changes. The goal is to understand the biological link between stress and suicidal thinking, not to test ketamine as a new treatment.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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New York State Psychiatric Institute
New York, New York, 10032, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine hydrochloride infusion
What this could lead to
If successful, this could reveal how ketamine reduces suicidal thoughts, pointing toward better treatments for depression-related suicide risk.
What could go wrong
This is a very small early-phase study with only 12 participants, so results may not apply broadly. It focuses on understanding brain mechanisms, not proving a treatment works.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.