Scientists to watch depression treatment reshape the brain in real time
NCT ID NCT07620288
First seen Jun 09, 2026 · Last updated Jun 22, 2026 · Updated 4 times
Summary
This study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the brain mechanisms behind the treatment, not to test if it works.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Royal's Institute of Mental Health Research
Ottawa, Ontario, K1Z 7K4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
repetitive Transcranial Magnetic Stimulation (rTMS) - specifically intermittent Theta Burst Stimulation (iTBS)
What this could lead to
If successful, this study could reveal exactly how this brain stimulation treatment changes the brain, helping to develop faster and more effective depression therapies.
What could go wrong
This is a very small, early-stage study (20 people) with no control group, so results may not apply to everyone. It is designed to understand brain changes, not to prove the treatment works.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.