MAJOR DEPRESSIVE DISORDER (MDD)
Clinical trials for MAJOR DEPRESSIVE DISORDER (MDD) explained in plain language.
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Can a common antipsychotic stop the spiral of negative thoughts?
Symptom relief OngoingThis study looks at whether adding a low dose of aripiprazole to a standard antidepressant can help people with major depression who struggle with repetitive, uncontrollable negative thoughts (rumination). About 108 adults will receive either the antidepressant alone or the antid…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: NA • Sponsor: Central South University • Aim: Symptom relief
Last updated May 26, 2026 03:18 UTC
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New hope for depression? experimental drug ONO-1110 enters Mid-Stage trial
Symptom relief OngoingThis study tests a new medicine called ONO-1110 in 100 people with major depressive disorder. Half will get the drug, half a placebo, to see if it safely reduces depression symptoms over 8 weeks. The goal is to find better treatment options for those struggling with depression.
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: PHASE2 • Sponsor: Ono Pharmaceutical Co., Ltd. • Aim: Symptom relief
Last updated May 26, 2026 02:48 UTC
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Zapping the Brain's fear center to lift depression fast
Symptom relief ENROLLING_BY_INVITATIONThis study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) aimed at the right amygdala to quickly reduce depression symptoms. Fifty adults with major depressive disorder will receive either real or sham stimulation over…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: NA • Sponsor: Ruijin Hospital • Aim: Symptom relief
Last updated May 22, 2026 13:54 UTC
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Flashing lights could lift depression: new study tests safety
Symptom relief OngoingThis early study tests whether a special flashing white light can safely help ease depression symptoms. Thirty adults with mild to moderate major depressive disorder will receive 10 light sessions over two weeks, while staying on their current medication. Researchers will monitor…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: NA • Sponsor: University of Sao Paulo • Aim: Symptom relief
Last updated May 22, 2026 13:52 UTC
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Exercise as medicine: new study tests if workouts can lift depression
Symptom relief OngoingThis study looks at whether a 12-week physical activity program can improve depression symptoms in adults with major depressive disorder. 110 participants on antidepressants are randomly assigned to either join the exercise program or continue usual care. Researchers will track c…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: NA • Sponsor: IRCCS Centro San Giovanni di Dio Fatebenefratelli • Aim: Symptom relief
Last updated May 20, 2026 11:55 UTC
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New depression drug SPT-300 moves to safety check in 360 adults
Symptom relief ENROLLING_BY_INVITATIONThis study tests the safety of a new drug called SPT-300 in adults with major depression, with or without anxious distress. About 360 people who finished a previous SPT-300 study will take the drug for 6 weeks. Researchers will monitor side effects and overall safety.
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: PHASE2 • Sponsor: Seaport Therapeutics • Aim: Symptom relief
Last updated May 20, 2026 11:54 UTC
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Psychedelic therapy under the microscope: did it help?
Knowledge-focused OngoingThis study looks back at 376 patients who received LSD or psilocybin therapy for hard-to-treat depression, anxiety, PTSD, or addiction. Researchers want to see if the intensity of the psychedelic experience relates to better outcomes. No new treatments are given—only existing med…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: University Hospital, Geneva • Aim: Knowledge-focused
Last updated May 26, 2026 03:19 UTC
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Brain scans reveal hidden links between autism and depression
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how the brains of people with autism, depression, or both differ from those without these conditions. Researchers will use brain scans and electrical recordings to measure brain activity and inflammation. The goal is to better understand these conditions, not …
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: National Taiwan University Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 03:12 UTC
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Brain study seeks to uncover Depression's impact on emotional Decision-Making
Knowledge-focused OngoingThis study looks at how depression changes the way people process emotions and make decisions. Researchers will compare 120 adults with major depression to 120 healthy volunteers, all aged 21 to 80. Participants complete thinking tasks and brain scans (MEG/MRI) to measure emotion…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated May 26, 2026 03:11 UTC
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Can your income and friends predict brain disease?
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how things like social support, income, and lifestyle habits are linked to mental health and brain changes in people with conditions like depression, schizophrenia, Alzheimer's, and Parkinson's. About 1,310 European adults will complete surveys and optional br…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated May 22, 2026 13:52 UTC
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Brain tissue study aims to uncover synapse secrets in mental illness and dementia
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at brain tissue from people who donated their brains after death, and at nerve cells grown in a lab from patients. The goal is to find out how synapses (the connections between brain cells) are different in people with schizophrenia, depression, bipolar disorder,…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated May 20, 2026 11:55 UTC
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Vitamin d may alter brain waves in depressed women
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at whether giving vitamin D to women with depression and low vitamin D levels can change their brain wave patterns, measured by a non-invasive EEG test. The goal is to understand if vitamin D affects brain activity and mood. The study involves 34 women aged 20-40…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: NA • Sponsor: Bangladesh Medical University • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC
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Saliva test may reveal who benefits from psychedelic therapy for depression
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at whether a natural chemical called oxytocin, measured in saliva during a psychedelic therapy session, can help predict how well people with hard-to-treat depression will respond to treatment. Researchers will track 80 adults with major depressive disorder who a…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: University of Geneva, Switzerland • Aim: Knowledge-focused
Last updated May 13, 2026 16:01 UTC
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Blood test breakthrough could revolutionize brain disease diagnosis
Knowledge-focused ENROLLING_BY_INVITATIONThis study is analyzing blood samples from 1,799 people with brain diseases (like Alzheimer's, dementia, depression, and schizophrenia) and healthy volunteers. Researchers want to see if certain substances in the blood can help doctors diagnose these conditions more accurately. T…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated May 11, 2026 20:41 UTC