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Exercise as medicine? new trial tests workouts for depression

NCT ID NCT06989944

Symptom relief Sponsor: IRCCS Centro San Giovanni di Dio Fatebenefratelli Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a 12-week physical activity program can reduce depressive symptoms in adults with major depressive disorder. 110 participants are split into two groups: one continues antidepressant treatment alone, the other adds a tailored exercise routine. Researchers will measure changes in mood, brain activity, and biological markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
physical activity program
What this could lead to
If it works, this could point toward a simple, drug-free way to help manage depression symptoms.
What could go wrong
This is a small, early-stage study (110 people) looking at many different outcomes, so results may not be conclusive or widely applicable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * Primary diagnosis of depression (DSM-5 criteria) * Symptoms of depression according to MADR, BDI, ZDR Scale * Ability to provide written IC * Self-reported moderate-intensity leisure PA\< 150 min/week Exclusion Criteria: * Severe psychopathology * Medical contraindications to PA (PAR-Q) * Orthopedic problems/diseases which limit physical fitness assessment * Currently pregnant (or planning to become pregnant)

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Conditions

The condition(s) this trial relates to.

major depressive disorder Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder (MDD)

Contacts and locations

Locations

  • Azienda Sanitaria Locale di Pescara

    Pescara, 65124, Italy

  • IRCCS Centro San Giovanni fi Dio Fatebenefratelli

    Brescia, 25125, Italy

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Istituto Neurologico Mediterraneo Neuromed, NEUROMED

    Isernia, 86077, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.