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Brain study seeks to unravel emotional thinking in depressed older adults

NCT ID NCT05966532

Knowledge-focused Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study looks at how older adults with major depression handle emotions and make choices compared to healthy adults. Researchers will use brain scans and computer tasks to measure emotional recognition, reward processing, and impulsivity. The goal is to better understand the brain mechanisms behind depression in aging, which could guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify specific cognitive and brain patterns linked to depression in older adults, pointing toward better diagnostic tools or targeted therapies.
What could go wrong
This is an early-stage observational study, not a treatment trial. It may not lead to direct clinical changes, and results may not apply to all people with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 276 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Investigators will study 120 participants aged 21-80 years old with major depressive disorder (MDD). Participants with MDD will undergo clinical and neurocognitive assessment, and MEG/MRI procedures at one time point. Investigators team will also enroll 120 demographically matched comparable, never-depressed healthy participants (controls) to establish cognitive benchmarks. Healthy controls will complete clinical and neurocognitive measures at one time point. To attain a balanced sample of adults across the lifespan, research teams will enroll participants such that each age epoch (e.g., 21-30, 31-40, etc.) has a total of ten subjects (n=10) in both the healthy control cohort and depressed cohort.

Ages

21 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male and female participants 2. Age between 21-80 years old 3. DSM-5 diagnosis of major depressive disorder (MDD) based on Mini Neuropsychiatric Interview 4. Inventory of Depressive Symptomatology-Clinician Rated version (IDS-C) total score \> 14 5. Able to read, write, and comprehend English 6. Provide informed consent; willing to comply with study protocol Exclusion Criteria: 1. History of bipolar disorder, schizophrenia, or schizoaffective disorder 2. Presence of psychotic features 3. Lifetime central nervous system (CNS) disease (including head injury with loss of consciousness \> 5 minutes) 4. History of neurodevelopmental disorder (e.g., Autism spectrum disorder) 5. History of medical conditions that can affect neurocognitive function as well as be confounded with age (e.g., thyroid disease, endocrine illnesses) 6. Women who are pregnant 7. Current use of medications with known impacts on neurocognitive function (e.g., acetylcholinesterase inhibitors, amphetamine, methylphenidate, vortioxetine, sedatives) 8. Alcohol/substance use disorder within past 3 months 9. DSM-5 diagnosis of major cognitive impairment 10. Current sensory or physical impairment that interferes with testing. 11. Contraindication to MRI and MEG (only for depressed participants) (e.g., any electronic / metallic implants near or within the head or body, claustrophobia)

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy adult volunteer Major depressive disorder (MDD)

Contacts and locations

Locations

  • University of Texas Arlington

    Arlington, Texas, 76010, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390-9127, United States

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