MAJOR DEPRESSIVE DISORDER (MDD)

This study tests a long-acting injection of cariprazine given once a month under the skin. It is for people with schizophrenia, bipolar I disorder, or major depressive disorder who are stable on other medications. The goal is to see if the injection is safe, tolerable, and effect…

This study is testing whether an experimental medication called ACP-211 can help adults with major depressive disorder who haven't gotten better with standard antidepressant treatments. Researchers will compare ACP-211 against a placebo (inactive pill) to see if it reduces depres…

This study tests whether lifestyle changes—like regular exercise, a Mediterranean diet, and cognitive training—can prevent memory and thinking problems in adults aged 50-80 who have depression or depressive symptoms but no current cognitive decline. Researchers will compare three…

This study tests a new medicine called SPT-300 in 360 adults with major depression, with or without anxiety. Participants will receive either the drug or a placebo for 42 days to see if it reduces depression symptoms. The goal is to find a safer, more effective treatment option.

This study tests whether a new drug, CYB003, can safely and effectively reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 330 participants will receive either one of two doses of CYB003 or a placebo, added to their current antidepressan…

This study tests an experimental nasal spray called (R)-Ketamine (PRT-042) to see if it can quickly reduce depression and suicidal thoughts in adults with major depressive disorder. About 98 participants will receive either the spray or a placebo, and researchers will measure cha…

This study tests a new combination pill (dextromethorphan and bupropion) in 30 adults with major depression. Participants take the medication for two weeks and undergo brain scans to see if it changes how the brain responds to rewards. The goal is to understand if this treatment …

This early study is testing whether adding ketamine tablets to a new antidepressant can quickly reduce depression symptoms in adults with major depressive disorder. Twelve participants will take four doses of the study drug over one week while starting their regular antidepressan…

This study tests a noninvasive device that uses mild electrical currents to stimulate the brain, which people can use at home to treat major depression. Researchers will compare the active device to a placebo in 200 adults who are already taking antidepressants. The goal is to se…

This study tests whether a safe, at-home brain stimulation method called tDCS can help people with depression that hasn't improved with standard treatments. Ten adults with major depression will use a headset at home for 20-minute sessions, five times a week for two weeks, while …

This study is testing whether a noninvasive technique called transcranial magnetic stimulation (TMS) can improve symptoms in people with major depression. TMS uses magnetic fields to gently stimulate a part of the brain involved in mood and decision-making. The trial will enroll …

This study looks at whether adding a structured exercise program to a type of brain stimulation called iTBS can help people with depression that hasn't responded to medication. The researchers will compare the combination of exercise and iTBS to iTBS alone in 20 physically inacti…

This study tests whether adding milsaperidone to current antidepressant treatment helps reduce depression symptoms in adults whose current medication isn't working well enough. About 500 people with major depressive disorder will receive either milsaperidone or a placebo (inactiv…

This study tests whether a quick, 5-day course of deep transcranial magnetic stimulation (dTMS) can safely reduce depression in adults aged 60-85 who haven't gotten better with medication. Participants will receive either real or placebo stimulation to see if the treatment is wel…

This study tests a new therapy for major depression that uses real-time brain scans (fMRI) to help people shift their attention away from negative thoughts. 80 adults with depression will either get real feedback or a fake version to see if this training reduces symptoms. The goa…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression and anxiety in adults with COPD, ALS, multiple sclerosis, or atypical Parkinson disease. 108 participants will receive either two moderate-to-high doses or two very low dos…

This study tests whether a new drug called SPN-821 can help adults with major depression when added to their current antidepressant. About 230 people will receive either SPN-821 or a placebo for 29 days. The main goal is to see if the drug reduces depression symptoms more than pl…

This early-stage study tests whether suvorexant, a medication used for insomnia, is safe and tolerable for veterans with major depression who are at high risk for suicide. Thirty participants will take the drug daily for four weeks and complete questionnaires and computer tasks t…

This study tests whether a gentle brain stimulation device used at home can help ease depression symptoms. About 438 adults with major depression will either receive the stimulation plus their usual care, or usual care alone. The goal is to see if this safe, non-invasive treatmen…

This study tests whether a combination of physical activity, cognitive training, and dietary supplements can reduce depression symptoms and help prevent memory loss in people aged 50-80 with major depressive disorder. Researchers will measure mood, thinking skills, and gut health…

This study tests whether adding a physical therapy program—with gentle exercise and health education—to standard care can improve quality of life for adults hospitalized with major depression. Fifty participants will do twice-weekly sessions of mobility, strength, balance, and re…

This study compares two new group therapies for major depression: one that helps people change rigid negative expectations, and another that boosts sensitivity to positive experiences. 150 adults with depression will be randomly assigned to one of these therapies or a waiting lis…

This study tests a non-invasive brain stimulation treatment called TMS for teens and young adults (ages 15-25) with depression and suicidal thoughts. The treatment is given over 5 days and uses MRI to guide targeting. Researchers want to see if it reduces depression and suicide r…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can reduce depressive symptoms in people with borderline personality disorder (BPD). Sixty adults with BPD and moderate-to-severe depression will receive either real or fake tDCS sessions at hom…

This study tests if using magnetic brain stimulation right before electroconvulsive therapy (ECT) can make ECT work better for people with hard-to-treat depression. About 50 adults with severe depression will receive both treatments, and researchers will measure changes in seizur…

This study tests whether Lemborexant, a sleep medication, can help adults with treated depression who still struggle with insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep and symptoms. The goal is to see if the drug is pract…

This large study in Pakistan tests a three-step mental health plan for breast cancer survivors who also have depression. Over 26,000 women who finished initial cancer treatment will receive either the adaptive plan (starting with guided self-help, then therapy, then medication if…

This study tests whether four ketamine infusions over two weeks can rapidly reduce suicidal thoughts in 36 adults with major depression. Participants will also have two MRI brain scans to see if changes in brain structure relate to symptom improvement. The goal is to find a fast-…

This study tests if a new drug called DT-101 can help adults with major depression. About 300 people will receive either DT-101 or a placebo. Researchers will check mood changes using questionnaires over several weeks.

This study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from a healthy donor — can help adults with major depression who don't respond quickly to antidepressants. About 214 participants will receive either FMT or a placebo, and researchers will…

This study tests whether deep transcranial magnetic stimulation (dTMS) is safe and helpful for teens aged 14-18 who are in the hospital for major depression. Sixty participants will receive either real or sham dTMS alongside their usual care. The goal is to see if dTMS can ease d…

This study follows 252 people whose major depression is in remission to find early warning signs of relapse. Researchers will track symptoms, sleep, physical activity, thinking skills, and brain activity. The goal is to build a tool that helps doctors predict and prevent future d…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study looks at how depression symptoms, stigma, and psychological resilience differ between men and women. Researchers will compare 90 adults diagnosed with major depressive disorder to better understand gender-specific patterns. The goal is to improve recognition and treatm…

This study uses powerful 7T MRI brain scans and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare 320 patients and healthy volunteers aged 18-45 to improve diagnosis …

This study follows 204 people with depression to see if brain activity and genetic tests can predict who can safely stop taking antidepressants without relapsing. Participants will have brain wave tests, sleep recordings, and blood draws during treatment. The goal is to find biol…

This study aims to see how well a new survey (CIDI 5.0) can identify people who have had depression, anxiety, or PTSD at some point in their lives. Researchers will compare the survey results to a detailed clinical interview, which is the current gold standard. About 300 adults i…

This study explores whether a non-invasive device that stimulates the vagus nerve through the ear can improve motivation and mood in people with depression. Researchers will compare 60 depressed patients and 60 healthy volunteers, looking at how insulin sensitivity affects the re…

This study will follow 1,000 teenagers hospitalized for depression or bipolar disorder. Researchers will collect blood samples, brain scans, wearable device data, and psychological tests to find patterns that predict how well a teen responds to treatment. The goal is to better un…

This early-phase study at the University of Pennsylvania will use a special brain scan (GluCEST) to measure changes in a brain chemical called glutamate after a single ketamine infusion. Ten adults with treatment-resistant depression will be scanned before and after the infusion,…

This study is testing whether a smartphone app called EMOCARE can accurately track depression symptoms compared to standard questionnaires. About 104 adults with mild to severe depression will use the app for 6 weeks while also completing regular surveys. The goal is to see if th…

This study looks at how a brain protein called mGluR5 might help explain why cognitive behavioral therapy for insomnia (CBT-I) can also improve depression. Researchers will measure changes in this receptor and sleep patterns in 42 adults with major depression and insomnia. The go…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study looks at brain activity in 100 adults with major depression who are receiving a type of brain stimulation called accelerated TMS. Researchers use a special imaging technique (TD-fNIRS) to measure brain responses before, during, and after treatment. The goal is to find …