Brain scans may predict who can quit antidepressants without relapse
NCT ID NCT07328373
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether brain activity tests can tell if it's safe for people with depression to stop taking antidepressants. About 204 people will have brain scans, sleep tests, and blood draws to see if their brains return to normal with treatment. The goal is to find a way to stop medication with a lower chance of depression coming back.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 204 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients who get diagnosed with major depressive disorders according to DSM-IV or DSM-V
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Outpatients * For patients, satisfying Major Depressive Disorder for Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) * Drug-free for at least 1-week Exclusion Criteria: * Any neurological and psychiatric comorbid conditions * Hearing loss * Physical diseases
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Prof. Dr. Kemal Arıkan's Psychiatry Clinic
RECRUITINGIstanbul, 34380, Turkey (Türkiye)
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