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Ketamine therapy shows promise for alcohol and depression in early trial

NCT ID NCT07247370

First seen Jan 04, 2026 · Last updated Jun 22, 2026 · Updated 26 times

Summary

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. The main goals are to see if people stay in the study and to monitor side effects, not yet to prove the treatment works.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Drug Health Services, Royal Prince Alfred Hospital

    Sydney, New South Wales, 2050, Australia

    Contact Phone: •••-•••-••••

    Contact Email: •••••@•••••

    Contact

    Contact

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Ketamine

What this could lead to

If this works, it could point toward a new treatment approach for people struggling with both alcohol dependence and depression.

What could go wrong

This is a very early, small pilot study with only 20 participants. It is designed mainly to check safety and feasibility, not to prove effectiveness. Results may not apply to broader populations.

Conditions

The condition(s) this trial relates to.

alcohol abuse major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.