Freezing nerves to ease CP pain: new hope for stuck muscles?

NCT ID NCT07321366

Symptom relief Sponsor: Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a procedure called cryoneurolysis, which uses cold to temporarily block nerves that cause painful muscle tightness in the shoulder and elbow. It is for people with cerebral palsy who have not found relief from other treatments. The goal is to see if it helps them reach personal goals, like less pain or better movement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: cryoneurolysis (a procedure that uses cold to temporarily block nerve signals)
What this could lead to: If it works, this could offer a new, less invasive option to reduce pain and muscle tightness in people with cerebral palsy who cannot have surgery or Botox.
What could go wrong: This is a very small pilot study (40 people) with no control group, so results may not be conclusive. The effects are temporary, and there is a risk of side effects like nerve damage or pain from the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with cerebral palsy treated at the CMCR des Massues, regardless of their functional status as defined by their gross motor function level on the GMFCS (Gross Motor Function Classification System) and their manual ability level on the MACS (Manual Ability Classification System). * Presenting with disabling and/or painful muscle hyperactivity in the shoulder and/or elbow, * Aged over 12 years, * At a therapeutic impasse: contraindicated or refusing surgery, contraindication or insufficient efficacy of oral treatments (analgesics, baclofen, Artane), too short duration of efficacy of toxin injections (\<3 months) and/or dose-weight limitation not allowing treatment of all necessary sites. * Patient (and legal representatives in the case of a minor patient or guardian/curator in the case of an adult patient under legal protection measures) who has been informed and has signed the informed consent form for participation in the research, * Patient affiliated with a social security scheme. Exclusion Criteria: * \- Patients who have received a botulinum toxin injection (any location) within 3 months prior to inclusion. * Change in analgesic and/or antispastic treatment within 5 weeks prior to inclusion - Refusal to allow the patient's medical data to be used for research purposes * Contraindication to peripheral motor block and/or cryoneurolysis (haemostasis disorder, skin infection, Raynaud's syndrome, cryoglobulinaemia, cold urticaria). * Pregnant/breastfeeding patients. * Cognitive and/or behavioural disorders that prevent participation in the study or giving consent to participate

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Cerebral palsy (CP) are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

cerebral palsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral palsy (CP)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Freezing nerves to ease CP pain: new hope for stuck muscles?

What the study statuses mean