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Could a 'Mirror' brain stimulation trick help stroke and amputee patients?

NCT ID NCT05766059

Symptom relief Sponsor: Istituto Auxologico Italiano Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a new non-invasive brain stimulation technique called mirror-PAS, which combines visual and motor signals to promote brain plasticity. Researchers will compare it to standard brain stimulation in 36 people with stroke-related arm weakness or phantom limb pain. The goal is to see which method better improves movement and reduces pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial Magnetic Stimulation (TMS) with paired associative stimulation
What this could lead to
If it works, this could point toward a new non-invasive treatment to help stroke survivors regain movement and reduce phantom limb pain.
What could go wrong
This is a very early, small study (36 people) testing only short-term effects. The approach may not lead to lasting improvement or work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for stroke patients: * age from 18 to 85 years * single, unilateral, hemispheric stroke (cortical or sub-cortical areas) * stroke confirmed by neuroimaging (CT or MRI) * stroke at least 4 months before enrollment * hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented Exclusion criteria for stroke patients: * contraindications to TMS (Rossi et all, 2021) * other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS) * other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome) Inclusion criteria for PLP patients: * age from 18 to 90 years * amputation of one part of the upper limb at least 2 months before enrollment * presence of stable phantom limb pain at least 2 months prior to enrollment Exclusion criteria for PLP patients: * contraindications to TMS (Rossi et all, 2021) * other neurological, orthopedical or psychiatric conditions

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Conditions

The condition(s) this trial relates to.

hemiplegia Paresis Phantom Limb stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemiparesis Phantom limb pain Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istituto Auxologico Italiano IRCCS

    RECRUITING

    Milan, Lombardy, 20122, Italy

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