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Could a simple pill help ICU patients get off IV blood pressure drugs faster?

NCT ID NCT05058612

Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether midodrine, an oral medication that raises blood pressure, can help intensive care unit (ICU) patients stop needing intravenous (IV) vasopressors sooner. About 870 adults with dangerously low blood pressure who are already improving will receive either midodrine or a placebo. The goal is to see if midodrine reduces deaths and shortens ICU stays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Midodrine (an oral blood-pressure-raising medication)
What this could lead to
If it works, this could help ICU patients get off IV blood-pressure drugs faster, potentially shortening their stay.
What could go wrong
This is a Phase 4 trial, but midodrine is not yet proven for this use. It may not reduce ICU stays or mortality, and side effects like high blood pressure or slow heart rate are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 870 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2021

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * Ongoing vasopressor support * Decreasing vasopressor dose(s) Exclusion Criteria: * Greater than 24 hours from peak vasopressor dose * Contraindication to enteral medications * Previously received midodrine in last 7 days * Expected death or anticipated withdrawal of life-sustaining therapies in next 24 hours * Pregnancy * Known allergy to midodrine

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Conditions

The condition(s) this trial relates to.

palsy Shock Vasoplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Vasoplegia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Alberta Hospital

    RECRUITING

    Edmonton, Alberta, T5R 0T1, Canada

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