University Of Alberta

This study tests whether a 12-week online program of exercise, nutrition advice, and behavioral support can improve physical function in people waiting for a liver transplant. About 177 adults with cirrhosis who are frail or pre-frail will be recruited from six Canadian transplan…

This study tests whether a personalized care plan, based on a patient's risk of future kidney problems and delivered through digital tools, can improve health after acute kidney injury. About 6,000 adults leaving Alberta hospitals will be randomly assigned to receive either the t…

This study tests whether two heart medications (empagliflozin and ranolazine) can help people with pulmonary hypertension and right heart failure. About 30 adults will receive either standard care alone or standard care plus one of the drugs. The main goal is to see if a larger s…

This study tests a drug called MTX228 to see if it can help regrow insulin-producing beta cells in adults with type 1 diabetes. About 24 participants will receive different doses to find the best one. The goal is to reduce the need for insulin injections and improve blood sugar c…

This study is for people who have lost an arm above the elbow and are getting a bone-anchored implant (osseointegration) along with nerve rerouting surgery (TMR). The goal is to see if a special muscle-signal training program helps them control a myoelectric (muscle-controlled) p…

This study looks at whether doing aerobic exercise before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Twenty adults with type 1 diabetes will train for 12 weeks, and researchers will track their insulin use and blood sugar levels. The go…

This study tests a custom mouthpiece called OrthoApnea NOA for people with obstructive sleep apnea who struggle with CPAP machines. Researchers will compare new users to past patients using other mouthpieces to see if the NOA cuts breathing pauses by at least half. The study also…

This study looks at whether adding extra fiber to metformin treatment works better than either alone for teens aged 12-18 with severe obesity and insulin resistance. Over 12 months, researchers will measure changes in insulin resistance, weight, and body composition. The goal is …

This study is testing whether fecal microbiota transplantation (FMT), or a 'poop transplant,' can help people with ulcerative colitis achieve remission without steroids. About 85 adults with active disease will receive either FMT or a placebo. The main goal is to see if a larger …

This study tests whether extra support from a community pharmacist can help people with type 2 diabetes better manage their blood sugar levels. About 600 adults with uncontrolled diabetes will either receive pharmacist-led care or continue with their usual doctor visits. The goal…

This study looks at women who have had breast surgery and radiation before and need another breast surgery. It compares three options after surgery: a week of antibiotics, a wound vacuum device, or no extra treatment. The goal is to see which approach best prevents wound complica…

This study looks at whether taking fish oil supplements along with the standard drug metformin can help protect the heart in women with Polycystic Ovary Syndrome (PCOS). PCOS often leads to high testosterone, which can cause blood sugar and cholesterol problems, raising the risk …

This study tests whether the drug sotatercept can improve lung function in people with pulmonary arterial hypertension (PAH), a condition that makes it hard to breathe. About 27 adults will receive the drug every 21 days for 29 weeks and undergo lung tests, heart ultrasounds, and…

This study compares two ways to treat aneurysms in a specific brain artery: open surgery (clipping) and a less invasive procedure (endovascular coiling or stenting). Researchers want to see which method works better and is safer for patients. About 400 adults with this type of an…

This study tests a 24-week digital wellness platform combined with online support from healthcare professionals to help endometrial cancer survivors reduce waist size and improve overall health. About 148 participants who have completed cancer treatment will take part. The goal i…

This study looks at whether giving two blood-thinning drugs (clopidogrel and aspirin) together for 21 days after a stroke is safe and works better than aspirin alone to prevent another stroke. About 200 adults who recently had a stroke and are at low bleeding risk will take eithe…

This study looks at whether taking antibiotics right after getting Botox injections in the bladder can lower the chance of getting a urinary tract infection (UTI). People with neurogenic overactive bladder often get Botox to help control symptoms, but UTIs are a common side effec…

This study tests whether a special ultrasound called fibroscan can help doctors safely lower the dose of anti-rejection drugs in liver transplant patients. These drugs are needed for life but can cause serious side effects like kidney damage, diabetes, and heart disease. The stud…

This study tests a personalized treatment using a patient's own immune cells, modified to attack cancer. It is for people with relapsed aggressive lymphoma or acute lymphoblastic leukemia (ALL) who have not responded to standard therapies. The approach aims to control the disease…

This study tests whether adding a freeze-dried fecal transplant (LFMT) to standard biologic therapy (vedolizumab or ustekinumab) is safe and helps more people with ulcerative colitis reach remission. About 40 adults with active UC will receive either LFMT or a placebo alongside t…

This study tests whether drinking traditional kefir for 12 weeks can improve blood sugar control and heart health in people who are overweight and either at risk for or already have type 2 diabetes. Researchers will measure changes in HbA1c (average blood sugar) and other health …

This study tests whether a home-based exercise bike linked to a video game (MedBIKE) can help 10 children, aged 10-18, who have had a heart transplant improve their fitness. The program lasts 12 weeks and uses short, intense bursts of exercise. The main goal is to see if the prog…

This study looks at whether using a home blood pressure monitor plus a dedicated case manager can help people with chronic kidney disease and high blood pressure living in remote areas better control their blood pressure. About 146 participants will either use the monitor with th…

This study looks at whether giving a lower dose of continuous dialysis (CRRT) to critically ill patients with sudden kidney failure is safe and works as well as the standard dose. About 100 adults in the ICU who need dialysis will be randomly assigned to receive either the standa…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study is testing whether a blood test (called Prospera) can accurately detect kidney transplant rejection, potentially replacing the need for a kidney biopsy. Researchers will compare the blood test results with standard biopsy and other lab tests in 300 kidney transplant re…

This study is testing a new radioactive tracer called 18F-PSMA-1007 for PET/CT scans to see if it can better detect where prostate cancer has spread in the body. About 2800 adults who have already been treated for prostate cancer but have signs of possible recurrence will get the…

This study is testing a new molecular test to detect rejection in heart transplant patients more accurately than current methods. Researchers will analyze biopsies from 900 participants to see if the test can identify rejection types in real time. The goal is to improve diagnosis…

This study aims to improve how doctors diagnose problems in transplanted kidneys. Current methods can be wrong, leading to poor treatment. Researchers are testing a new system that combines genetic and tissue information to give a more accurate diagnosis. The study will involve 5…

This study is testing whether a blood test (DD-cfDNA) can accurately detect heart transplant rejection, potentially replacing the need for invasive heart biopsies. Researchers will compare the blood test results with standard biopsy and antibody tests in 300 heart transplant reci…

This study tests a new radioactive tracer called 68Ga-HA-DOTATATE for PET/CT scans in people with known or suspected neuroendocrine tumors. The goal is to see if it is safe and more accurate than older imaging methods. About 600 participants will be enrolled to measure how well t…

This study is testing a special PET scan (18F-DOPA) to see if it can better detect and measure several conditions, including congenital hyperinsulinism in children, neuroblastoma, neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. About 800 children…

This study tests whether a brain-computer interface (BCI) game can assess cognitive skills like attention and memory in children aged 7-16 with motor impairments. Traditional tests require physical responses, which may underestimate these children's abilities. By using brain sign…

This study tests whether a new type of ultrasound (microUS) is as good as MRI for finding prostate cancer. About 1,284 men aged 50-70 with elevated PSA will be randomly assigned to get either a microUS or an MRI. The goal is to see which method better detects serious prostate can…

This study aims to see if giving women a short course of antibiotics after bladder Botox injections can prevent urinary tract infections, which are a common side effect. Researchers will compare infection rates between women who receive real antibiotics versus placebo pills for t…

This study tests a program called GLA:D Back, originally from Denmark, to help people with low back pain that lasts at least one month. The goal is to adapt the program for English-speaking Canadians and see how many clinicians and patients use it. Participants must not be in oth…

This study tests whether using virtual reality (VR) games during speech therapy can help adults with voice disorders stick with their exercises and get better results. Researchers will compare VR-based therapy to standard care in 30 adults receiving treatment at a rehabilitation …

This study tests if a home-based video game exercise bike can improve fitness in 44 teens (ages 10-18) with repaired congenital heart disease. Participants use the MedBIKE for high-intensity interval training, guided remotely by a coach. The goal is to see if this fun, telemedici…

This study tests whether Schroth exercises, a type of physical therapy, can reduce pain and improve daily life for adults over 50 with degenerative scoliosis (a sideways curve of the spine). Twenty participants will either do the exercises or just be observed. The main goal is to…

This study tests a new way to help people with early knee osteoarthritis by having pharmacists and physiotherapists work together. Participants will get advice on pain relief and exercise to manage their condition. The goal is to see if this team approach improves knee function a…

This study looks at whether a 10-week exercise program, done in-person or online, can help people with multiple myeloma maintain their physical fitness, muscle strength, and quality of life while they undergo chemotherapy before a stem cell transplant. The trial will include 30 a…

This early study looks at whether a specific protein fragment (IRW) from egg whites can help manage high blood sugar and blood pressure. About 28 adults at risk for or with type 2 diabetes, plus healthy volunteers, will drink a smoothie with the protein and have their blood and b…

This study looks at whether letting children with neurodevelopmental disabilities (like autism or cerebral palsy) set their own therapy goals leads to better outcomes. About 96 kids aged 5-12 and their therapists will be split into two groups: one using a child-focused goal-setti…

This study looks at whether eating more traditional Inuit foods (like fish and game) and taking part in cultural activities can help reduce depression and anxiety. About 40 Inuit adults in Arviat, Nunavut will be followed for 12 weeks. Researchers will measure mood changes and ho…

This study compares two types of wrist fusion surgery for people with wrist arthritis caused by past injuries. 170 adults with stage II or III SLAC or SNAC wrist will be randomly assigned to have either a four-corner fusion or a three-corner fusion (which also removes a small bon…

This study tests if a supervised stationary cycling program can reduce nerve pain and improve daily function in people who have chemotherapy-induced peripheral neuropathy (CIPN). Thirty adults with cancer who have mild CIPN will cycle for 30-60 minutes twice a week for 12 weeks. …

This study tests whether a pill called midodrine can help ICU patients with dangerously low blood pressure stop using intravenous (IV) vasopressors sooner. About 870 adults whose blood pressure is improving but still need IV support will receive either midodrine or a placebo. The…

This study tests whether custom-made non-invasive ventilation (NIV) masks improve comfort and adherence in children aged 8-12 who already use NIV but struggle with mask fit. Each child gets a 3D-printed mask based on a facial scan. Researchers will compare sleep quality, mask lea…

This study tests whether a child-focused goal-setting method called ENGAGE helps kids with disabilities like autism or cerebral palsy get more out of therapy. About 96 children aged 5-12 and their therapists will be split into two groups: one using ENGAGE and one using usual care…

This study is testing a mind-body program called DNRS for people with ME/CFS (chronic fatigue syndrome) who may also have Long COVID. The program uses brain retraining to help reduce symptoms like fatigue, pain, and anxiety. Researchers will measure quality of life, daily activit…

This study tests whether a smartphone app called MyIBDDiet can help people with inflammatory bowel disease (IBD) learn about and follow an anti-inflammatory diet. About 40 adults with IBD who are not currently having a flare-up will use the app for one month. Researchers will mea…

This study looks at whether closely watching jaw movement and starting physical therapy early can help prevent or reduce jaw tightness (trismus) in people with head and neck cancer who are getting radiation. About 30 participants will be tracked weekly during treatment and given …

This study is for people who have had an allogeneic bone marrow transplant for blood cancer. Recovery is very hard, with long-lasting physical and emotional side effects. The APOLLO team will give participants a smartphone app and phone support from nurses, exercise, and nutritio…

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who had chemotherapy for breast cancer. Chemo can weaken the heart and reduce physical ability, but exercise might help. Researchers will compare a structured exercise pr…

This study tests whether taking taurine supplements can reduce brain fog, fatigue, and other thinking and memory problems in people with Long COVID. Researchers will enroll 300 adults who had COVID-19 at least 3 months ago and still have symptoms. Participants take taurine or a p…

This study tests whether a heavy lifting strength training program can help head and neck cancer survivors regain muscle strength, reduce fatigue, and improve quality of life. About 60 adults who finished cancer treatment at least one year ago will be randomly assigned to either …

This study tests a home-based telerehabilitation program for stroke survivors who did not receive outpatient therapy. Two hundred participants will use wearable sensors and game-like exercises guided remotely by therapists. The goal is to improve arm and hand movement and make re…

This study tests a therapy that uses a brain-computer interface (BCI) and electrical stimulation to help children aged 12 to 17 with hemiparetic cerebral palsy improve arm and hand function. When a child imagines moving their wrist, the system detects the brain signal and stimula…

This study tests whether giving Gamma Knife radiation very early after diagnosis of trigeminal neuralgia (a severe facial pain condition) provides longer-lasting pain relief than waiting until medications stop working. About 80 adults with a recent diagnosis will either receive e…

This study looks at whether a low dose of ketorolac, an NSAID painkiller, can safely reduce the need for opiates in critically ill ICU patients. Opiates are effective but can lead to dependence after leaving the hospital. The trial will enroll 30 adults in the ICU who are in pain…

This study tests whether adding extra-corporeal shock wave therapy (ESWT) to standard Botox injections can better reduce muscle stiffness and improve quality of life in adults with upper limb spasticity caused by stroke, brain injury, or cerebral palsy. Forty participants will be…

This study tests whether giving a small electrical stimulation to the nerve before surgery can help people with severe cubital tunnel syndrome recover better. About 30 adults will receive either real or fake stimulation before their operation. The goal is to see if this simple ad…

This study tests whether adding a text-message support program (Text4Support) to standard brain stimulation therapy (rTMS) helps people with treatment-resistant depression more than rTMS alone. About 200 adults who have not gotten better with at least two antidepressants will tak…

This study tests a 'rooming-in' program where mothers and babies stay together in a quiet hospital room instead of separating the baby to the NICU. About 240 full-term infants exposed to opioids during pregnancy will take part across Alberta hospitals. The goal is to reduce NICU …

This study tests whether a type of light therapy called photobiomodulation can help people with obstructive sleep apnea use their CPAP machine more comfortably. About 30 adults who currently use CPAP but have trouble tolerating it will receive the light treatment. The goal is to …

This study looks at whether wearing a lumbar brace for 4 weeks after an ER visit for low back pain can lower pain, improve spine function, and reduce the need for painkillers. About 152 adults aged 18-65 in Edmonton will be enrolled. The goal is to find a safer, non-drug option f…

This study tests whether sildenafil, a pill that widens blood vessels in the lungs, can help people with mild COPD exercise longer and feel less short of breath. Researchers will measure exercise capacity and breathing patterns in 160 participants. The goal is to see if improving…

This study looks at whether using portable oxygen during physical activity can improve quality of life, exercise ability, and shortness of breath in people with mild-to-moderate interstitial lung disease. About 60 participants will receive oxygen for 8 weeks, with some also getti…

This study is testing a new program where Indigenous patient navigators help young adults (ages 16-25) with chronic health conditions as they move from pediatric to adult healthcare. The program was co-designed with Elders, community members, and healthcare providers in Maskwacis…

This study compares AI-generated translations of a health resource with professional human translations. About 350 adults in Canada whose first language is French, Spanish, Ukrainian, Tagalog, Arabic, Chinese, or Punjabi will review one version and answer questions to see how wel…

This study follows 40 lung transplant patients who are at high risk for CMV infection because the donor had CMV but the recipient did not. Researchers want to see how often the virus shows up in the blood while patients are taking the antiviral drug valganciclovir. They will also…

This study tests a new MRI technique using ferumoxytol to get clearer images of tiny blood vessels in the brain's memory center. It involves 50 adults with temporal lobe epilepsy and healthy volunteers. The goal is to find better ways to predict who will benefit most from epileps…

This study aims to see if a blood test (dd-cfDNA) can accurately detect lung transplant rejection compared to standard biopsy methods. Researchers will enroll 600 adult lung transplant recipients to compare blood test results with tissue analysis and antibody tests. The goal is t…

This study looks at how often very low birth weight babies on breathing machines get lung infections in Canadian hospitals. Researchers will compare how different hospitals diagnose and treat these infections to create a standard, evidence-based approach. The goal is to reduce in…

This study involves 210 men with low-risk prostate cancer who are on active surveillance (monitoring instead of immediate treatment). Researchers will compare two imaging methods—micro-ultrasound and MRI—to see which better detects cancer progression during follow-up biopsies. Pa…

This study is testing a noninvasive technique that uses mild electrical pulses on the skin over the spine to see if it can improve arm and hand function in people who have had a stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement in 30 ad…

This study looks at liver transplant biopsy samples to learn more about how the body may reject the new organ. Researchers will analyze gene activity in 300 biopsy samples to create a test that can identify different types of rejection more accurately. Participants are people who…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (ankle equinus) in children aged 4-17. About 42 kids having surgery for this condition will have the plantaris and larger calf muscles lengthened in a random order. The goal is to se…

This study looks at how much protein people with colorectal or breast cancer need to keep their muscles strong during treatment. Muscle loss is common in cancer patients and can lead to worse health outcomes. Researchers will use a simple, non-invasive test to measure protein nee…

This study is for children aged 10-18 with certain heart conditions or who have had a heart transplant. Researchers will use special MRI scans taken during exercise to see how the heart and skeletal muscles work together. The goal is to learn more about what affects fitness in th…

This study tests whether physiotherapists who practice dry needling can improve their needle placement accuracy and safety by reviewing anatomy on donated bodies (cadavers). Sixty physiotherapists will be split into two groups: one gets a cadaver anatomy class, the other gets unr…

This study looks at whether using a tiny camera in a pill right after a negative stomach scope can find the source of bleeding faster than the usual approach. About 70 adults with signs of upper gut bleeding but a clear stomach exam will be randomly assigned to get the camera or …

This study will test if wearable monitors can safely track heart failure in 100 children aged 8-18 at home instead of in the hospital. The monitors measure heart rate, breathing, and activity, sending data to doctors to spot early warning signs. The goal is to see if this approac…

This study looks at whether a special dental appliance that expands the upper jaw can also help the lower jaw grow forward in children aged 9 to 11 with a deep overbite. Sixty kids will get either an active or a non-active expander, and doctors will use 3D X-rays to measure chang…

This study provides a 9-week education program for family members who care for young adults (ages 17-27) with psychosis. The goal is to see if teaching families practical skills reduces their stress and helps the young person stay stable in the community. Researchers will measure…

This study follows 106 men who have had surgery for prostate cancer to learn how long it takes to regain bladder control, sexual function, and overall health. Participants receive standard care resources and are monitored for up to 12 weeks. The goal is to better understand recov…

This study looks at how semaglutide, a diabetes and weight-loss drug, affects fat around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers want to understand if changes in fat tissue can slow kidney disease. About 52 adults from …

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and remove medications too quickly. It focuses on adults in the intensive care unit with life-threatening brain problems like stroke, severe injury, or infection. Researchers w…

This study is building a large collection of health data and biological samples from 150 people with ALS and related conditions. The goal is to provide researchers worldwide with the information they need to better understand the disease and develop new treatments. Participants w…

This study looks at whether a new molecular test on lung biopsies can better diagnose rejection in lung transplant patients. Researchers will compare the test results with standard methods in 700 participants. The goal is to improve accuracy and possibly develop a safer biopsy te…

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans, physical tests, and blood draws. The goal is to understand how the drug affects muscle health, especially in people at ri…

This study is for people with advanced cancers who are taking targeted treatments for months or years. Researchers will interview 75 participants to understand their experiences and needs. The goal is to find better ways to support patients living with chronic cancer treatments.

This study looks at how much nimodipine, the only proven drug for brain aneurysm bleeds, actually gets into patients' blood. Researchers will measure drug levels in 500 adults across Canada and the US and check their recovery 90 days later. The goal is to understand why some pati…

This study is for women whose antibody levels against measles, mumps, rubella, or varicella are low despite having had two vaccine doses. Researchers will measure immune responses in women who already received a third dose through routine care. The goal is to understand if a thir…

This study tests whether viewing images from a PowerPoint slide set can help expand the visual field in people with hemianopsia (partial blindness) after a stroke or brain injury. Researchers will measure changes using a standard vision test. The study involves 40 adults who have…

This study looks at how the 'fight or flight' nervous system controls blood pressure differently in healthy men and women. Thirty participants aged 18-40 will have their nerve activity, blood flow, and response to tiny doses of blood pressure medications measured. The goal is to …

This study is testing a new, standardized care pathway for children who need a tracheostomy (a breathing tube in the neck). The goal is to help these children leave the hospital sooner and reduce stress for their families. The pathway includes digital tools, education, and suppor…

This study aims to understand how different types of exercise—aerobic (like walking) and resistance (like weight lifting)—affect blood sugar levels in post-menopausal women with type 1 diabetes. Twenty participants will wear a continuous glucose monitor and complete three separat…

This study looks at whether orthodontic treatment with twin block and hyrax devices can improve breathing in children aged 8-14 who have a small lower jaw and a narrow upper jaw. Researchers will measure changes in airway size and airflow using 3D scans and models. The goal is to…

This study tests whether MRI can accurately measure fluid buildup in the lungs of people hospitalized for acute heart failure. Researchers will track how lung water changes during treatment and see if these measurements can predict who is at higher risk of returning to the hospit…

This study will test a new, evidence-based approach to delivering emergency dialysis (renal replacement therapy) to 4500 patients in Alberta intensive care units. The goal is to improve patient outcomes and reduce healthcare costs by standardizing care. Researchers will track key…

This study looks at whether using a higher (60%) or lower (30%) oxygen concentration when resuscitating extremely premature babies (born before 29 weeks) leads to better survival and brain development by 18-24 months of age. About 1,200 babies across multiple hospitals will take …

This study looks at a new way to set breathing machine pressure for people with obesity who need a ventilator. It involves 30 patients with a BMI of 30 or higher. The goal is to see if this method is practical and safe enough to test in a larger study.