University Of Alberta

This early-stage study tests a new vaccine designed to protect against hepatitis C virus (HCV). The main goal is to check the vaccine's safety and see how well it triggers the body's immune system to produce antibodies. The study will involve 27 healthy adults aged 18 to 45 who d…

This study tests whether starting Tezepelumab, a monthly injection, in the emergency room can help adults with severe asthma recover faster and prevent future attacks that require another ER visit or steroid pills. About 100 adults aged 18-55 who have severe asthma and are on hig…

This study looks at what amount of oxygen is safest for babies born a few weeks early (32 to 35 weeks). Doctors will compare giving 60% oxygen versus 30% oxygen right after birth to see which helps babies breathe better and need less breathing support later. Over 1,500 babies in …

This study will test several different treatments at once in 1,000 adults with heart failure. The goal is to see which treatments help people live longer and stay out of the hospital. Participants will be randomly assigned to one of the treatment options being studied.

This study tests whether giving a heart medication called dobutamine early, before signs of heart failure appear, is safe and possible in newborns with HIE who are already receiving cooling therapy. Forty babies will be randomly assigned to receive either the medication or a plac…

This study will test a self-balancing robotic exoskeleton called XoMotion-R in 16 people with spinal cord injury (SCI) who have some movement in their legs. The device allows users to walk hands-free, which may help those who cannot use crutches or walkers. Researchers want to se…

This study looks at whether a procedure to replace a narrowed heart valve (TAVI) is safe when done in a hospital that does not have emergency heart surgery available. Currently, the standard is to have this procedure only where surgery is on-site. About 600 people with severe aor…

This study tests a new way to treat a fast-growing blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has a specific mutation (BCR-ABL). About 80 adults will get two drugs: ponatinib pills and blinatumomab injections under the skin. The goal is to see if this co…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The approach uses two devices: a blood pressure cuff on the arm that briefly restricts blood flow, and inflatable leg sleeves that pump blood upward. The go…

This study looks at three types of patch grafts (donor sclera, cornea, and pericardium) used in glaucoma surgery to help control eye pressure. Researchers will compare how well each graft works, how safe they are, and what patients think about them. The goal is to find the best o…

This study compares two CPR methods for newborns who have a cardiac arrest right after birth. The standard method uses 3 chest compressions for every 1 breath. The new method combines a sustained inflation with chest compressions. The goal is to see if the new method lowers the n…

This study tests a mobile app that gives people with diabetes, heart disease, or kidney disease simple instructions on when to temporarily stop certain medications during illnesses like the flu or stomach bug. The goal is to prevent serious side effects such as dangerously low bl…

This study tests whether a yeast-based protein supplement can build muscle as effectively as whey protein in healthy adults aged 18-35 who already do resistance training. Over 16 weeks, 72 participants will take either yeast or whey protein while exercising. The main goal is to c…

This study tests whether adding a beta-glucan moisturizing cream to standard skin care helps heal incontinence-associated dermatitis (a painful rash) faster and reduces discomfort like pain and itching. About 60 adults with the rash will either get the cream plus standard care or…

This study tests a program called Connecting Today, which helps care home residents with moderate to severe dementia have weekly video calls with family or friends. About 320 people (80 residents and their loved ones) will take part. The goal is to see if these calls improve qual…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than usual care. About 25 adults who had a spinal cord injury within the past year will take part. Their walking speed, endurance, and daily activity will be measur…

This study tests a new pessary that is custom-shaped to each woman's body for treating pelvic organ prolapse (POP). About 43 women who already use a standard pessary will try the new device for 3 months and report on comfort and symptoms. The goal is to see if the custom fit redu…

This study tests whether a medication called dexmedetomidine can improve sleep for patients in the intensive care unit (ICU). Poor sleep in the ICU can harm the immune system, heart, and brain. The study will compare sleep quality between two groups of 50 adults: one receiving th…

This study tests if using augmented reality (AR) games can help people with brain injuries stick with their rehab therapy. Researchers will have 30 adults try the GlenXRose AR program alongside standard care to see if it improves how often they practice and their overall recovery…

This study looks at whether teaching mindfulness skills to pregnant women who are at risk of delivering early (before 37 weeks) can help lower their stress, anxiety, and depression. About 60 women admitted to the hospital will take part in mindfulness sessions for four weeks. The…

This study tests a vibrating device to reduce pain during retinal laser treatment for diabetic retinopathy. About 50 people will have one eye treated with the device and the other without, then rate their pain. The goal is to see if vibration can make the procedure more comfortab…

This study tests whether a special ketone drink can help people hospitalized with acute heart failure. Sixty participants will receive either the drink or a placebo for five days. Researchers will measure changes in heart stress markers and symptoms to see if the drink improves r…

This study tests whether caffeine can improve breathing in newborns who have meconium aspiration syndrome (MAS) and still need oxygen after 10–14 days. Twenty babies will receive either caffeine or a placebo. Researchers will measure oxygen levels and use lung ultrasound to see i…

This study tests whether a one-hour electrical stimulation during mastectomy surgery can help restore lost sensation in the breast and nipple. Thirty women having both breasts removed preventively will receive the stimulation on one breast only, and their sensation will be tested…

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods (like packaged snacks) affects blood potassium levels in people with advanced chronic kidney disease. 48 participants will try four different 10-day diets, with all meals provid…

This study looks at whether breathing in nitric oxide can improve how well the lungs exchange oxygen during exercise in people with mild to moderate COPD. Researchers will measure lung blood vessel function and breathing efficiency in 80 participants (40 with COPD and 40 healthy …

This study will collect information from up to 100,000 critically ill patients in intensive care units (ICUs) around the world who receive continuous kidney dialysis (CRRT). The goal is to understand how different hospitals use this treatment and how it affects patient outcomes. …

This study will check if a small, portable device called Wellvii VitalDetect can accurately measure blood pressure, heart rate, and temperature at home for patients recovering from surgery. About 69 adults will use the device at home and also get standard measurements during week…

This study aims to develop and test artificial intelligence (AI) tools to help doctors prescribe and deliver acute dialysis more effectively for critically ill patients in the ICU. Researchers will analyze data from 7,500 patients to create algorithms that predict better outcomes…