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Blood test could replace painful biopsies for lung transplant patients

NCT ID NCT05837663

Knowledge-focused Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study aims to see if a blood test (dd-cfDNA) can accurately detect when a lung transplant is being rejected, compared to the standard method of taking a tissue sample (biopsy). Researchers will enroll 600 adult lung transplant recipients to compare blood test results with biopsy findings and antibody tests. The goal is to make rejection monitoring easier and less invasive for patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2023

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All adult lung transplant recipients undergoing indication biopsy for suspected graft dysfunction will be eligible.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adult, Older adult Exclusion Criteria: Patients will be excluded from the study if they decline participation Are unable to give informed consent. Recipients of multiple organs, cancer patients and pregnant women

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung transplantation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    19 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Alberta Transplant Applied Genomics Centre, University of Alberta

    RECRUITING

    Edmonton, Alberta, T^g 2E1, Canada

  • BAYLOR SCOTT & WHITE RESEARCH INSTITUTE , 3409 Worth Street

    RECRUITING

    Dallas, Texas, 75246, United States

  • Charles University/Hospital Motol

    RECRUITING

    Prague, Czechia

  • Department of Medicine, University of Alberta

    RECRUITING

    Edmonton, Alberta, T6G 2G3, Canada

  • Department of Thoracic Surgery, Medical University of Vienna

    NOT_YET_RECRUITING

    Vienna, Austria

  • Division of Pulmonary, Allergy & Critical Care Medicine Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, College of Medicine

    RECRUITING

    Gainesville, Florida, 32610, United States

  • Houston Methodist Lung Transplant Center, 6550 Fannin St., SM1001

    RECRUITING

    Houston, Texas, 77030, United States

  • Indiana University Methodist Hospital 1812 N. Capitol Ave Suite W131L

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Johns Hopkins Interventional Pulmonology, Sheikh Zayed Tower, Room 7125L, 1800 Orleans Street

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Mayo Clinic Florida, 4500 San Pablo Rd

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Motol University Hospital, V Uvalu 84

    RECRUITING

    Prague, 15006, Czechia

  • St. Joseph's Hospital and Medical Center 350 West Thomas Road, Floor 8HLT

    RECRUITING

    Phoenix, Arizona, 85013, United States

  • The Alfred Hospital, Monash University

    RECRUITING

    Melbourne, Australia

  • The Ohio State University Wexner Medical Center, 410 W 10th Ave

    RECRUITING

    Columbus, Ohio, 43210, United States

  • USF Health, Morsani College of Medicine, 12901 Bruce B. Downs Blvd. MDC40

    NOT_YET_RECRUITING

    Tampa, Florida, 33612, United States

  • UT Health San Antonio 7703 Floyd Curl Drive, MSC: 7858

    RECRUITING

    San Antonio, Texas, 78229, United States

  • UT Southwestern Medical Center, 5939 Harry Hines Blvd.

    RECRUITING

    Dallas, Texas, 75390, United States

  • University Health Network, Toronto General Hospital

    RECRUITING

    Toronto, Ontario, M5G 2C4, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.