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Can muscle strength predict lung transplant recovery?

NCT ID NCT07747337

Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study looks at adults awaiting lung transplantation to see how the strength and structure of breathing and limb muscles relate to physical performance and recovery after surgery. Participants will undergo ultrasound imaging, strength tests, and physical performance assessments before and after transplant. Researchers will also track hospital stay and rehabilitation from medical records. The goal is to understand if muscle weakness contributes to frailty and delayed recovery, which could lead to better pre-transplant care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Respiratory and limb muscle assessments (ultrasound, strength testing, physical performance measures)
What this could lead to
If successful, this could help identify muscle weaknesses that predict slower recovery, guiding pre-transplant rehabilitation to improve outcomes.
What could go wrong
This is a small observational study, so it may not prove cause and effect. Results may not apply to all lung transplant patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult lung transplant candidates receiving care at UF Shands hospital. Participants are individuals with advanced lung disease undergoing evaluation and treatment while awaiting lung transplantation in the hospital. The study population includes adults who are able to complete study assessments of respiratory and limb muscle function before transplantation and during the early postoperative recovery period.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years or older. * Hospitalized as potential candidates for single- or bilateral-lung transplant surgery. * Hemodynamically stable for out-of-bed mobilization Exclusion Criteria: * Baseline cognitive impairment * History of previous solid organ transplantation or thoracic surgery * Existing phrenic nerve lesion * Lower limb amputation or fracture * External fixators or open wounds of the lower extremities * Diagnosed neuromuscular disorder. * Morbid obesity (body mass index \>45 kg/m²). * Any other medical condition that, in the opinion of the investigators, would make participation unsuitable.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

End-stage lung disease Lung transplantation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UF Health Shands Medical Center

    RECRUITING

    Gainesville, Florida, 32608, United States

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