University Of Florida

This study tests a personalized RNA vaccine for children and young adults (ages 3–39) whose medulloblastoma has returned after standard treatment. The vaccine is made from the patient's own tumor and aims to train the immune system to fight the cancer. The main goals are to see i…

This early-phase trial tests a custom-made RNA vaccine designed to help the immune system recognize and attack tumors in people with advanced melanoma or soft tissue sarcoma whose cancer has worsened despite standard immunotherapy. Up to 18 adults will receive three doses of the …

This study tests whether a drug called tocilizumab-aazg is safe for people who have had a burst brain aneurysm. The goal is to see if it can also help prevent strokes that sometimes happen after the initial bleeding. The study will include 30 adults and focuses on safety and side…

This study tests whether minocycline, an antibiotic, can lower blood pressure in people whose hypertension does not respond to standard treatments. Researchers will explore if the drug works by changing gut bacteria, reducing inflammation, or calming brain signals. About 120 adul…

This study tests a decision tool to see if it can safely identify women with bladder cancer who can keep their reproductive organs during bladder removal surgery. Currently, standard surgery removes the bladder along with the uterus, ovaries, and part of the vagina, which can cau…

This study tests a new type of brain stimulation using two leads instead of one to better control severe essential tremor. Ten adults who already have a standard deep brain stimulation (DBS) implant will receive the new dual-lead system. The goal is to see if it improves tremor c…

This study compares two blood-thinning medications, prasugrel and ticagrelor, when taken alone (without aspirin) by people with heart disease who have had a stent placed at least 90 days earlier. The goal is to see if one is better at preventing blood clots. The study will involv…

This pilot study tests whether adding a GLP-1RA weight-loss drug (like semaglutide) to a hormone-releasing IUD can shrink or clear early endometrial cancer in obese patients who are not good candidates for hysterectomy or wish to preserve fertility. About 20 adults will be follow…

This study looks at two add-on treatments for Duchenne muscular dystrophy (DMD): a drug called tadalafil that improves blood flow, and aerobic exercise training. The goal is to see if these can improve muscle function and delay disease progression. About 50 ambulatory children wi…

This study is for people with a favorable type of throat cancer caused by HPV. Researchers want to see if giving less intense radiation and chemotherapy, based on the patient's HPV type and virus levels in the blood, can control the cancer just as well as standard stronger treatm…

This study compares two strategies to reduce bleeding risk in people who take two blood thinners after having a stent placed in their heart. The goal is to see if lowering the dose of one drug works as well as switching to a different drug. About 78 adults who have had a stent wi…

This study looks at whether removing the parathyroid gland can improve physical function and mobility in adults aged 60 and older with primary hyperparathyroidism. Participants will have surgery and then complete walking tests, wear activity monitors, and give blood samples. The …

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid to help the donor cells fight solid tumors that have come back or not responded to treatment. It includes children and young adu…

This study tests a two-step treatment for adolescents and young adults recently diagnosed with type 1 diabetes. First, participants receive a low dose of anti-thymocyte globulin (ATG) to calm the immune system, then verapamil to reduce stress on insulin-making cells. The goal is …

This study tests a new way to treat advanced liver cancer by using artificial intelligence to find the best dose of three drugs for each patient. The goal is to make treatment more effective while reducing side effects. About 12 adults with advanced liver cancer who cannot have s…

This study tests whether using a genetic score (ABCD-GENE) to guide reducing blood thinners after heart stent placement works better than the usual approach. About 90 adults who have had a stent and are on two blood thinners will be randomly assigned to either a gene-guided or st…

This study looks at whether high-intensity interval training (short bursts of hard exercise) can lower the risk of heart disease in women who finished chemotherapy for breast cancer. About 158 women who completed chemo 6 to 18 months ago will be assigned to either high-intensity …

This study is testing a program to help cancer survivors and their family members or caregivers quit using tobacco or nicotine products. The program includes personalized support for quitting and training for healthcare providers on how to talk to patients about tobacco use. Abou…

This study tests if combining three treatments—electric field therapy (TTFields), laser ablation surgery, and an immunotherapy drug (pembrolizumab)—is safe and doable for adults with recurrent glioblastoma, an aggressive brain cancer. About 20 participants will receive the combin…

This study tests whether a lower dose of the blood thinner ticagrelor works better than the standard clopidogrel in stable heart disease patients who are at high risk for a heart attack during a stent procedure. About 50 adults will be enrolled and their blood's ability to clot w…

This study tests whether a mobile app that lets teens record themselves taking their anti-rejection medications can improve how consistently they take them. About 100 adolescent heart transplant recipients will use the app or standard care. The goal is to reduce hospitalizations …

This study looks at whether switching from a standard blood thinner (clopidogrel) to a lower-dose one (prasugrel) can better control blood clotting in heart patients who have both high bleeding and high clotting risks after getting a stent. About 40 adults who have been on dual b…

This study looks at whether adjusting the dose of the blood thinner cangrelor based on individual test results can better control clotting risk in people with coronary artery disease who need to pause their regular medication before surgery. About 50 adults will receive either a …

This study tests whether putting two chemotherapy drugs (gemcitabine and docetaxel) directly into the bladder can keep low-grade bladder cancer from returning. About 34 adults with intermediate-risk, non-invasive bladder cancer will receive the treatment. The goal is to see if th…

This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to train the immune system to fight aggressive brain cancers like glioblastoma and high-grade glioma. The study enrolls up to 28 adults and children to check safety, manufacturing …

This expanded access program offers a special stem cell processing technique (CD34+ selection) to patients with severe combined immune deficiency, Fanconi anemia, dyskeratosis congenita, or sickle cell disease who are receiving a stem cell transplant. The method removes certain i…

This study looks at two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed. One approach switches patients from a strong blood thinner to a milder one while keeping aspirin. The other stops aspirin and keeps the strong blood thinner a…

This study compares three ways to help people stop smoking: two mobile health apps (iCanQuit and iCanQuit+Motiv8) and the Florida quit line. About 1,332 adults who get care at participating clinics and have a smartphone will take part. The goal is to see which approach works best…

This study tests whether adding a special PET-CT scan (POSLUMA) to standard MRI can better detect serious prostate cancer in men with uncertain MRI results (PIRADS 2 or 3). About 30 men who have not had a biopsy before will receive both scans and then a targeted biopsy. The goal …

This study aims to increase HPV vaccination rates among 9- to 12-year-olds in rural North Central Florida. Researchers are testing three levels of support: training for doctors, reminders and motivational calls for parents, and help accessing healthcare. About 4,630 children and …

This study tests a free, self-paced online program that teaches adults how to reduce their risk of colorectal cancer through better nutrition and regular screening. Participants complete six lessons covering diet tips and screening options like colonoscopy and home stool tests. T…

This study tests a web-based program that teaches parents how to manage their child's exposure to substance use in movies, TV, and online. Researchers will enroll 120 parents of middle-schoolers to see if the program improves media parenting behaviors. The goal is to reduce youth…

This study looks at whether doing breathing-strengthening exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who smoke or have lung problems. Participants will practice breathing exer…

This study looks at a new way to do a special arm massage (manual lymphatic drainage) to prevent lymphedema, a common side effect of breast cancer surgery. About 30 women having lymph node removal will be assigned to either standard massage or massage guided by a green dye that s…

This early-phase study tests whether combining oxytocin with oxycodone can reduce the risk of opioid abuse while still relieving pain. Researchers will give 45 older adults different combinations of the drugs across six sessions and measure pain, subjective effects, and decision-…

This study tests whether a nutritional supplement called Epidiferphane can reduce common side effects of taxane chemotherapy, such as nerve damage and anemia, in breast cancer patients. About 74 participants will take Epidiferphane alongside their standard chemo to see if it help…

This study tests a new way to treat worsening heart failure at home using a small injection of Lasix under the skin. It aims to see if this approach can safely reduce symptoms like fluid buildup and prevent hospital stays. About 100 adults with heart failure and fluid overload wi…

This study tests whether giving extra oxygen early after a traumatic spinal cord injury is safe and practical. Twelve adults with neck or back spinal cord injuries will receive 10 sessions of high-oxygen therapy while on a breathing machine. The goal is to see if this approach ca…

This study tests whether a new type of deep brain stimulation (DBS), called patterned stimulation, is safe and tolerable for people with Parkinson's disease to use at home. About 60 adults who already have stable DBS will try the new pattern for two weeks. The goal is to see if t…

This study looks at how to improve quality of life and mental health for people with a Left Ventricular Assist Device (LVAD) and their family caregivers. Over two months, participants fill out surveys about their well-being and may get handouts or a brief meeting with a psycholog…

This study tests whether walking exercise—done at a center or at home—can help reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who finished cancer treatment in the past year will take part. The goal is to find a simple, effective way to ease tire…

This study looks at whether taking zinc every day can make Botox injections last longer for people with cervical dystonia, a condition that causes painful neck muscle spasms. About 25 adults will take either zinc or a placebo for 3 months, then switch for another 3 months. Resear…

This small pilot study tests whether the drug Linaclotide, taken with Gatorade, can clean the bowel for a colonoscopy as well as the standard 4-liter prep. Ten adults scheduled for a colonoscopy will take two doses of Linaclotide and drink 2 liters of Gatorade instead of the usua…

This study tests whether adding melatonin to standard cooling treatment can help protect the brains of newborns with HIE (a birth injury from lack of oxygen). About 70 full-term babies will receive different doses of melatonin to find the safest and most effective amount. The goa…

This study looks at whether drinking cranberry juice every day for 70 days can help healthy adults aged 30 to 55 think more clearly and stay calm under pressure. Participants will do mental and physical tasks while researchers measure their stress levels, mood, and gut health. Th…

This small study is testing whether a wearable device that gently vibrates the arm muscles can help people with multiple sclerosis (MS) use their hands and arms better. Fifteen adults with relapsing-remitting MS will use the device at home for four weeks. The goal is to see if th…

This study looks at whether adding four virtual physical therapy sessions to standard home exercises helps runners with leg pain feel better and move better. About 85 runners aged 18 to 65 who run at least 12 miles a week will take part. Researchers will measure pain and movement…

This study tests a device called Walkasins that provides gentle vibrations to the legs to replace lost foot sensation. Researchers want to see if it helps 30 older adults (ages 65-95) with foot numbness walk more automatically and with less mental effort. Participants will walk w…

This study looks at whether Parent-Child Interaction Therapy (PCIT) can help parents of children aged 2-7 who have behavioral concerns. Researchers will measure changes in anxiety, depression, stress, and even oxytocin levels using surveys and saliva samples. The goal is to see i…

This study tests a new method to program deep brain stimulation (DBS) for Parkinson's disease using the brain's own electrical signals, instead of the usual manual trial-and-error. Researchers will compare two signal-based approaches to see which one improves motor symptoms like …

This study tests a light-based treatment called photobiomodulation (PBM) for pain caused by temporomandibular disorder (TMD). Researchers will compare real PBM to a sham (fake) treatment in 130 adults to see if it reduces daily pain. The goal is to find a new, non-drug way to man…

This study looks at whether a 2-week gratitude journaling activity is practical and helpful for people with long-term jaw pain (TMD) and other chronic pain conditions. About 60 adults aged 18 to 80 will try writing in a journal three times a week and report on their pain and sati…

This study tests whether group counseling and peer support can help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain feel less stigma about their health. About 195 adults will join counseling sessions and report how stigma affects their li…

This study tests a new, non-invasive treatment called transcranial pulse stimulation (TPS) that uses low-intensity magnetic pulses on key brain areas. Researchers will compare changes in thinking and brain function between 10 healthy older adults and 10 people with mild dementia.…

This study tests whether a gentle nerve-stimulation device (tVNS) can make exposure therapy work better for people with OCD. About 56 adults with moderate to severe OCD will receive tVNS during therapy sessions. The goal is to see if this combination reduces obsessive thoughts an…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other major trauma will receive either fluoxetine or a placebo for several months. Researchers w…

This study is for people with non-invasive breast cancer (DCIS) who are having a mastectomy. Normally, surgeons remove lymph nodes at the same time, but most of these removals are unnecessary. The study uses a special iron-based dye called Magtrace that stays in the lymph nodes f…

This pilot study tests whether a gentle nerve stimulation technique (taVNS) can improve the ability to understand speech in noisy environments for adults aged 55 to 80 with age-related hearing loss. Participants will complete speech perception tasks while receiving either active …

This study tests a new way to use deep brain stimulation (DBS) for essential tremor. Normally, DBS delivers constant electrical pulses to the brain, but over time this can lose effectiveness and cause side effects like numbness or speech problems. The new approach automatically t…

This study tests whether regular, friendly phone calls can improve mental health and reduce loneliness in older adults who are homebound. About 400 people aged 65 and older will receive either supportive calls from trained helpers or no calls during the study. The goal is to see …

This study looks at whether a daily dose of kava can help smokers who want to quit. Researchers will check if kava makes it easier to stop smoking, reduces stress, and improves sleep. About 76 adult smokers will take kava and report their progress over several months.

This study tests whether a 6-week exercise program before reverse shoulder replacement surgery can improve how well you can rotate your arm inward afterward. About 64 adults aged 40 to 80 will take part. Half will do the pre-surgery exercises, and half will follow standard care. …

This study tests a 6-week exercise program for older adults (ages 65-90) who recently finished home health care and have trouble moving or thinking. Participants will do task-oriented resistance exercises at home with a care partner. The goal is to see if this program is practica…

This study tests whether a novel exercise program using both arms and legs can protect heart function in women with breast cancer who are undergoing chemotherapy. Researchers will measure blood vessel health and heart strain in 68 participants. The goal is to find a safe, tolerab…

This study tests a wearable device that sends gentle, low-frequency electromagnetic fields to the brain to help people who had a stroke more than 6 months ago recover arm movement and reduce disability. About 25 adults with chronic stroke will use the device in a clinic setting. …

This study is testing whether cannabidiol (CBD) placed under the tongue can safely reduce knee pain from osteoarthritis and help people use fewer over-the-counter pain relievers like ibuprofen. Researchers will enroll 30 adults with moderate to severe knee pain. The goal is to se…

This study tests a gentle, noninvasive brain stimulation method called iTBS to see if it can improve memory, attention, and planning in older adults who had delirium while in the ICU. About 40 people aged 50 to 75 who are three months past their ICU stay will receive either real …

This study tests whether a numbing injection in the face can reduce severe headaches and the need for strong painkillers after a brain bleed. About 195 adults who had a brain bleed will receive either the active injection or a placebo. The goal is to see if this approach safely c…

This study looks at how serious injuries change the way bone marrow and muscles work in adults aged 18 to 54. Researchers want to understand why some people have trouble recovering from anemia and lose muscle mass after trauma. By analyzing blood and tissue samples, they hope to …

This study is testing a non-invasive thumb sensor that measures oxygen levels in tissue to see if it can help assess heart failure severity in children. About 130 participants under 25 with stable heart failure will have their thumb oxygen measured at rest and during a brief bloo…

This study uses MRI scans to monitor muscle damage and fat buildup in boys and men with Duchenne or Becker muscular dystrophy over 5-10 years. Researchers compare these images with healthy individuals and link them to daily activities like walking. The goal is to develop better w…

This study watches children aged 3 to 9 who need a special dental device called a distal shoe after losing a baby tooth early. The device helps guide their permanent teeth into place. Researchers want to see how often gum problems happen and what makes treatment work best. The go…

This study aims to understand how certain genes linked to type 1 diabetes affect the immune system. Researchers will follow 2,800 people over time, taking blood samples to see who develops diabetes. No treatment is given; the goal is to learn how the disease starts.

This study looks at how much the temperature inside a tooth rises when dentists use red light compared to standard blue light during fillings. Researchers will also check if patients have any tooth pain afterward. The goal is to see if red light is gentler on teeth. About 50 heal…

This study aims to see if artificial intelligence can predict which older adults with mild memory problems will improve with computer-based brain training. Researchers will use brain MRI scans from 75 participants to train a machine learning tool. The goal is to personalize cogni…

This study tests a noninvasive nerve stimulation device to see if it can improve how people with traumatic brain injury understand speech in noisy environments. Researchers will compare brain responses and speech test scores between a treatment and a placebo. The goal is to under…

This study is testing two blood tests that look for HPV DNA and RNA to see if they can track how well cervical cancer responds to surgery, radiation, and chemotherapy. About 55 adults with HPV-related cervical cancer will give blood samples before and after treatment. The goal is…

This study looks at how the thoughts and beliefs of people with chronic low back pain and their physical therapists influence how much they benefit from treatment. About 90 adults with low back pain will receive standard physical therapy including spinal adjustments, exercise, an…

This study aims to better understand Friedreich's ataxia by measuring heart function, nerve health, and exercise ability in 203 people with the condition. Participants will undergo MRI scans, echocardiograms, exercise tests, and skin or muscle biopsies. The goal is to find reliab…

This study looks at how people with fibromyalgia or rheumatoid arthritis experience pain differently. Researchers will measure pressure pain thresholds in 150 adults to compare pain processing in these conditions. The goal is to better understand pain mechanisms, which could lead…

This study looks at how effective endoscopic submucosal dissection (ESD) is for removing early-stage abnormal growths in the digestive tract. Researchers will track 300 adults who are already scheduled for ESD as part of their care. The main goal is to see how often the lesion ca…

This study looks at whether a gentle electrical current applied to the scalp (tDCS) can improve working memory in older adults with mild cognitive impairment (MCI). Researchers will compare results from 110 participants aged 60-95, including both people with MCI and healthy older…

This study tests a new method for marking the area where breast cancer was removed during surgery. The goal is to help radiation doctors see the exact spot on scans, making radiotherapy more precise and reducing the need for repeat surgeries. About 50 adults with early-stage brea…

This study looks at how a treatment called High-Intensity Focused Ultrasound (HiFU) changes brain activity in people with essential tremor, a condition that causes shaking. Ten adults over 50 who haven't been helped by standard medications will have their brain waves recorded bef…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. Researchers will measure changes in food security, di…

This study tests two short-term breathing therapies in 18 adults with a recent spinal cord injury (2 weeks to 6 months ago). The goal is to see which therapy better improves breathing strength and cough function. Researchers will also look at genes to understand why some people r…

This study looks at how severe infections (sepsis) and major injuries change the way the body produces certain immune cells. Researchers will measure specific white blood cells in 450 adults to understand why some people develop long-term immune problems. The goal is to learn mor…

This study tests a tele-education program that trains primary care providers at community health centers across the U.S. to improve diabetes care. Over six months, providers receive twice-monthly online sessions from experts at the University of Florida. The study will measure wh…

This study looks at how the shoulder tendon changes right after two different exercise programs. Researchers will use ultrasound to measure tendon thickness before and after exercise in 24 adults, some with shoulder pain and some without. The goal is to learn more about tendon he…

This study tests whether a web portal with a virtual health educator helps Black and Hispanic cancer patients in Florida learn about and sign up for clinical trials. About 350 adults will be randomly assigned to either a standard educational website or one with a virtual coach. T…

This study looks at how Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis affect white blood cells in the lungs called macrophages. Researchers will collect blood from 220 adults to test how well these cells work. The goal is to better understand these diseases, not to provide a…

This study gives dental providers a special workshop to improve how they interact with young children (ages 2-10) and their parents during dental visits. The training is based on a proven program for managing child behavior. Researchers want to see if the training changes how den…

This study looks at how severe injuries change the brain, bone marrow, and gut, and how these changes lead to long-term anemia and recovery problems. Researchers will study 275 adults with serious blunt trauma to understand these connections. The goal is to gather knowledge that …

This study aims to understand why pain levels differ from person to person and over time, and whether people can train their natural pain management systems, similar to athletic training. Researchers will study 180 adults, some with widespread muscle pain and some without, using …

This study tests whether adding oxytocin (the 'love hormone') to oxycodone can reduce pain while lowering the risk of addiction. Researchers will give 45 recreational opioid users different combinations of the drugs and measure pain relief, subjective effects, and brain activity.…

This study looks at whether a special score that combines genetics and patient information can identify people with stable coronary artery disease who are at higher risk for a heart attack or heart injury during a planned stent procedure. About 500 adults will be enrolled and fol…

This study looks at how emergency department (ED) doctors handle dental pain that isn't caused by injury. Researchers will interview 60 ED providers to understand what makes it easy or hard to treat these patients. The goal is to create a tool that helps doctors prescribe the rig…

This study looks at whether improving the clarity of instructions helps cancer patients attend all their scheduled radiation sessions and feel more at ease. Researchers will update patient materials and track missed treatments, unplanned clinic visits, and patient comfort. The st…

This study tests a new imaging technique that uses sound waves created by radiation to see exactly where proton therapy is hitting inside the body. Researchers want to see if this method can help doctors deliver radiation more accurately to prostate tumors. About 30 men with pros…

This study collects and stores brain tumor tissue samples from patients undergoing brain surgery. The samples are used for research to find better treatments and possibly cures for brain tumors. Up to 4,000 children and adults will participate.

This study looks at how aging affects the ability to learn who to trust. Researchers will use real-time brain scans to train 68 older adults to improve trust-related learning. The goal is to see if this training can help reduce the risk of elder fraud.

This study looks at whether adding polyphenol-rich foods like beans and lentils to your daily diet can improve skin health. Researchers will study 50 women aged 45-65 over 12 weeks, measuring skin redness, moisture, and other factors. The goal is to see if these foods change the …

This study looks at whether a single session of breathing exercises or spinal stimulation can prevent the diaphragm from weakening when a breathing machine is used. 16 healthy adults will try these rehab methods before using a noninvasive ventilator. The goal is to see if these a…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study tests whether short, repeated sessions of breathing low-oxygen air can improve breathing and other motor functions in people with chronic spinal cord injury. Researchers will also look for genetic markers that might predict who benefits most. About 62 adults with spina…

This study aims to learn more about Alpha-1 Antitrypsin Deficiency, a genetic condition that can affect the lungs and liver. Researchers will follow up to 50,000 people who are at risk due to symptoms or family history. Participants will fill out questionnaires to help track how …

This study tests whether wearing goggles that briefly block vision during balance training can help people improve their balance more effectively. Healthy adults aged 18-30 or 65-89 will practice walking on a narrow beam while wearing special goggles. Researchers will measure bal…

This study looks at how body position and the type of anesthesia used during robotic surgery for gynecologic cancer affect pressure inside the eye. About 40 women will take part. The goal is to see if using only IV anesthesia keeps eye pressure lower than standard anesthesia, whi…

This study from the University of Florida looks at how listening to calming music might help your health and well-being. Researchers will measure heart rate, collect saliva samples, and use surveys to see how music affects your body's stress response. The study involves two phase…

This study looks at how dry needling works to relieve chronic low back pain. Researchers will study 71 adults aged 18-65 who have had low back pain for at least 3 months. Participants will receive dry needling and complete surveys and tests to measure pain, muscle stiffness, and …

This observational study looks at how severe trauma changes the body's blood and bone marrow, aiming to understand why some patients become immune-suppressed and develop infections like sepsis. Researchers will collect blood and bone marrow samples from 255 trauma patients and co…

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy. Researchers will test 30 adults—some with nerve problems from chemo and some healthy—using a special device called ToeScale. Participants will also answer quest…