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Can CBD drops replace painkillers for knee arthritis?

NCT ID NCT06414473

Symptom relief Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether taking cannabidiol (CBD) extract under the tongue three times a day can safely ease knee osteoarthritis pain and reduce the need for NSAID painkillers. Thirty adults with moderate to severe knee pain will receive either CBD or a placebo for several weeks. Researchers will track pain levels, physical activity, and side effects to see if CBD is a viable alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cannabidiol (CBD) extract
What this could lead to
If it works, this could point toward a safer, natural option for managing knee osteoarthritis pain without the risks of long-term NSAID use.
What could go wrong
This is a small, early-phase trial (30 people) testing safety and basic effectiveness. CBD may not reduce pain better than placebo, and results may not apply to everyone with osteoarthritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. established clinical diagnosis of knee osteoarthritis (KOA) 2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees Exclusion Criteria: 1. pregnant (urine pregnancy test) or lactating 2. current cannabis (THC and/or CBD) use (urine drug screen) 3. any prior or ongoing medical condition that, in the investigators' opinion, could adversely affect the safety of the subject 4. any major surgery within 3 months prior to recruitment or planned orthopedic surgery for any time during this study which would interfere with the ability to report pain or quality of life outcome measures 5. any exposure to another investigational drug within 3 months prior to screening 6. BMI ≥ 45 7. current use of any enzyme-modifying drugs, including strong inhibitors or strong inducers of cytochrome P (CYP) enzymes 8. history of: 1. suicidal ideation or self-harm behavior 2. seizure disorder or traumatic brain injury, 3. liver or kidney disease, and 4. cardiovascular diseases

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Conditions

The condition(s) this trial relates to.

Motor Activity osteoarthritis osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sports Medicine Research Laboratory

    RECRUITING

    Gainesville, Florida, 32601, United States

More trials for these conditions

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