University Of Florida

This early-stage study tests a new RNA-based vaccine for adults whose glioblastoma (a fast-growing brain cancer) has come back. The main goals are to see if the vaccine can be made safely and to find the best dose. About 24 participants will receive the vaccine to check for side …

This early-stage study tests a combination of immune therapies in 12 children and young adults (ages 4-30) whose medulloblastoma has come back. The treatment uses specially trained immune cells, a vaccine, and stem cells, along with a drug that helps the immune system attack the …

This study provided a single patient with recurrent osteosarcoma (a type of bone cancer) access to a personalized treatment made from their own tumor's genetic material. The therapy uses RNA-loaded lipid particles to try to control the cancer. The study is no longer available and…

This study tests a drug called tazemetostat in people whose malignant peripheral nerve sheath tumors have returned, not responded to treatment, or spread. The goal is to see if the drug can shrink or stop the tumors. About 10 participants aged 12 and older will take the drug and …

This study tests a new RNA vaccine for children and young adults (ages 3-25) with recurrent high-grade glioma or osteosarcoma that has spread to the lungs. The vaccine aims to train the immune system to attack cancer cells. The trial will check safety, the right dose, and whether…

This study tests whether combining two drugs—atezolizumab (an immunotherapy) and tivozanib (a targeted therapy)—can shrink tumors in cancers that typically don't respond to immunotherapy alone. About 29 adults with advanced bile duct, gallbladder, breast, neuroendocrine, ovarian,…

This study tests whether newer blood thinners (rivaroxaban or ticagrelor) work better than the standard drug clopidogrel to prevent stroke, brain bleeding, or death in people with severely narrowed brain arteries. About 1,683 participants who recently had a stroke due to 70-99% b…

This study looks at 3,000 men with prostate cancer to compare two radiation treatments: proton therapy and standard photon therapy (IMRT). The goal is to see which one causes fewer side effects and better preserves quality of life, especially bowel function. Participants are trea…

This study tests whether metformin, a common diabetes medicine, is safe and tolerable for people with a specific genetic form of ALS (C9orf72 ALS). About 41 participants will take metformin for 24 weeks. Researchers will monitor side effects and measure changes in harmful protein…

This study tests a specially engineered donor graft (Orca-Q) in children and young adults with certain blood cancers who need a stem cell transplant. The goal is to see if this processed graft is safe and helps the new cells take hold. About 40 participants will be enrolled.

This study tests a new combination of three treatments for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal is to see if adding the immunotherapy drug pembrolizumab to standard chemotherapy and electric field therapy (Optune) can help patients live l…

This early-phase trial tests whether giving children with recurrent high-grade glioma a special type of stem cell treatment along with the immunotherapy drug nivolumab is safe and possible. The study involves 12 children whose brain tumors have come back after standard treatments…

This early-phase study tests whether a new type of immune cell therapy, made from the patient's own cells and modified to target a protein called CD70, is safe and feasible for adults with glioblastoma and children with high-grade gliomas. The therapy includes an extra modificati…

This early-stage trial tests a personalized treatment for children with recurrent neuroblastoma or a newly diagnosed brainstem tumor called DIPG. The approach combines targeted drugs with the child's own immune cells and stem cells, all customized to their tumor. The main goal is…

This study looks at whether a combination of three common heart medications (a statin, an ACE inhibitor or ARB, and aspirin) can reduce the risk of major heart problems in women who have chest pain or shortness of breath but no blocked arteries. About 2,500 women are taking eithe…

This early-phase trial tests a new treatment for a type of brain cancer called oligodendroglioma that has come back or is growing. The treatment uses the patient's own immune cells (dendritic cells, T cells, and stem cells) combined with targeted drugs. The main goals are to see …

This early-stage study aimed to test a drug made from black seed (NP-101) alongside standard radiation therapy for people with liver cancer that cannot be removed by surgery. The goal was to find the safest dose and see if it could help control the cancer. However, the study was …

This study tests whether a higher dose of proton radiation, precisely aimed at tumors seen on MRI, can better control high-risk prostate cancer. About 100 participants will receive radiation over 8-9 weeks, plus hormone therapy for 18 months. The main goal is to see if this appro…

This study tests whether a daily kava drink can help active smokers (who don't plan to quit) smoke less and lower their risk of lung cancer. Twenty adults who smoke at least 5 cigarettes a day will take kava for 4 months. Researchers will check how well participants stick with th…

This study looks at whether a time-restricted eating plan (fasting 16 hours each day) can improve memory and thinking in overweight adults over 65 who have mild memory concerns. Participants either follow the fasting plan or attend healthy aging classes for 24 weeks. The goal is …

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity or overweight plus related health issues will take part. Half will get a 52-week program with support, and the other half will receive educational ma…

This study tests a combination of three chemotherapy drugs (liposomal irinotecan, 5-FU, and oxaliplatin) given before surgery to people with pancreatic cancer that can be removed. The goal is to see if this approach is safe and helps reduce complications after surgery. About 45 a…

This study tests a new type of deep brain stimulator for people with essential tremor, a condition that causes uncontrollable shaking. Unlike standard devices that stimulate the brain constantly, this "closed-loop" system only delivers stimulation when it senses tremor activity. …

This study tests whether shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's. 168 volunteers aged 65-89 with memory concerns and a family history of Alzheimer's will receive either re…

This study looks at whether cranberry juice can prevent urinary tract infections (UTIs) in healthy women who are prone to them. Researchers will measure how well participants' urine blocks bacteria after drinking cranberry juice. The goal is to find out who might benefit most fro…

This study in Rwanda tests whether pregnant women who eat two eggs daily have babies with longer birth lengths compared to those who eat their usual diet. About 464 women will take part, starting in their first trimester. Researchers will measure baby growth, brain development, a…

This study tests whether a medication called istradefylline, combined with short periods of breathing air with less oxygen (acute intermittent hypoxia), can improve breathing in people with ALS. Researchers will compare results from 40 adults with ALS and healthy volunteers. The …

This study looks at whether adding epinephrine to a nerve block behind the cheekbones can lessen bleeding during sinus surgery for people with chronic sinusitis. About 80 adults will take part. The goal is to see if this approach makes the surgery smoother and safer.

This study tests whether a yeast cell wall extract (mannooligosaccharides and beta-glucans) can improve gut symptoms and gut bacteria in healthy adults aged 50-99. About 40 participants will rate their digestive symptoms daily. The goal is to see if this supplement can ease commo…

This study tests a gentle nerve stimulation technique to help people who have trouble speaking after a stroke or brain injury. Twelve adults will receive daily stimulation combined with speech therapy for 16 weeks. The goal is to see if this approach is safe and can improve speec…

This study tests whether taking a daily yeast supplement (12 grams) for 28 days can increase bowel movement frequency in generally healthy adults who currently have one or fewer bowel movements per day. The trial involves 70 participants and is double-blind, meaning neither the r…

This study looks at whether drinking cranberry juice every day for 70 days can help healthy adults aged 30 to 55 think more clearly, move more accurately, and feel less stressed when juggling multiple tasks. Researchers will measure heart rate, stress hormones, mood, and memory. …

This study looks at whether using a simple genetic test (CYP2D6) can help doctors choose the right opioid painkiller for each patient after elective ventral hernia repair. About 100 adults having surgery with mesh will either get standard pain management or a prescription guided …

This early-stage study tests a special cord blood product (CFL001) in 9 adults with sacroiliac joint pain. The main goal is to see if it is safe and to get an early look at whether it can reduce pain and improve daily function. Participants receive a single injection and are moni…

This study tests whether a nerve block placed in the face can reduce pain and the need for strong opioids after cleft palate repair in children. About 40 children having cleft palate surgery will receive the nerve block. The goal is to see if it helps them start eating and drinki…

This study looks at whether a fermented papaya supplement can help older adults (ages 70-80) make fewer mistakes while driving. Participants take three doses of the supplement in one day and then complete a driving simulator test. The goal is to see if the supplement improves att…

This study tests whether listening to music with special sonic enhancements can improve emotional health and calmness. About 76 adults aged 18-89 will listen to 15 minutes of music during an online Zoom session and complete surveys before and after. The goal is to see if the augm…

This study tests whether a non-invasive device that sends a mild electrical current to the spine can improve walking when combined with treadmill training. 18 adults with incomplete spinal cord injury will receive either real or fake stimulation during 36 sessions. The goal is to…

This study looks at whether giving very premature babies (born before 32 weeks and weighing less than 3.3 pounds) frequent, standardized mouth care every 3-4 hours can reduce harmful bacteria and lower the risk of lung infections like pneumonia. Researchers will compare this to c…

This study looks at why cranberry juice helps prevent urinary tract infections (UTIs) in some women but not others. Researchers think the answer lies in the gut microbiome—the bacteria living in our intestines. 160 healthy women who are prone to UTIs will drink cranberry juice or…

This study is testing a new method to monitor the immune system after a liver transplant. The goal is to see if a personalized approach can help doctors give the right amount of anti-rejection medicine, reducing the risk of rejection or infection. About 40 adult liver transplant …

This study looks at whether listening to music enhanced with Sonic Augmentation Technology (SAT) can improve health and wellness. About 36 adults aged 18-89 who work at UF Health Jacksonville will listen to a 15-minute music session and complete surveys and saliva tests. The goal…

This study looks at how different ways of processing sweet corn change its effect on blood sugar. About 45 healthy adults will eat sweet corn or drink a sugar solution on different mornings and have their blood sugar measured. The goal is to learn which corn products are better f…

This study compares how often lung nodules and lung cancers are found on chest X-rays before and after adding an artificial intelligence (AI) tool. Researchers want to see if the AI helps radiologists detect more actionable nodules and diagnose lung cancer earlier. The study incl…

This study tests a computer program called AID-P that reads brain scans to help doctors tell the difference between Parkinson's disease and two similar conditions. About 315 adults with these diseases will get an MRI and a checkup, and the computer's diagnosis will be compared to…

This study looks at whether a gentle brain stimulation technique called tDCS can improve how well the brain's networks work together during walking and navigation tasks. Researchers will test 60 older adults with mild memory concerns, giving them either real or fake stimulation w…

This study tests a web-based program to improve reproductive health knowledge in adults with sickle cell disease or trait who plan to have a child within two years. The program uses online quizzes and reminders to help participants understand genetic risks and parenting options. …

This study follows over 1,800 people who finished treatment for early-stage lung cancer to see how often they get follow-up CT scans. Researchers want to know if getting scans every 6 months helps find new cancers earlier or improves survival compared to yearly scans. The goal is…

This study examines how a specific gene variation (CYP2C19) influences the long-term risk of major heart problems, strokes, and limb complications in people with blood vessel disease. Researchers will analyze data from 13,000 patients who have already had genetic testing. The goa…

This study looks at whether a new microfluidic device can predict sepsis in premature newborns using just a tiny drop of blood. Sepsis is a life-threatening infection that is much more common in preterm infants. The researchers will measure how well the babies' white blood cells …

This study tracks over 1600 heart patients who had a stent placed and received genetic testing to help choose their blood thinner medication. The goal is to learn which patients benefit most from genotype-guided therapy and how to reduce risks like heart attack or bleeding. Resea…

This study looks at whether genetic testing can help doctors choose the right medications for people who often have less access to personalized healthcare. About 492 adults with at least three active prescriptions will have their genes tested to see if it improves their treatment…

This study looks at what happens when 40 adults eat yellow or white sweet corn every day for 4 weeks. Researchers want to see if it raises levels of lutein and zeaxanthin (nutrients important for eye health) in the blood and skin, and whether it affects digestion or gut bacteria.…

This study follows 347 heart surgery patients to find out why some develop swallowing problems (dysphagia) and how to spot them early. Researchers will create simple tools to predict risk and detect signs at the bedside. The goal is to improve care and prevent complications after…

This study looks at two different ways of screening mental health in elementary schools to help more African-American children get the support they need. About 19,000 students and school teams will take part. The goal is to see which screening method leads to more referrals to me…

This study looks at blood markers in 90 adults with sepsis who develop confusion or delirium. Researchers measure specific proteins over 72 hours to see if they relate to brain injury and survival. No treatment is tested; the goal is to better understand and predict brain complic…

This study tests whether a mild, non-invasive stimulation of the vagus nerve (through the ear) can help teenagers with dyslexia learn new letter-sound connections. About 100 adolescents with either typical reading skills or dyslexia will take part. They will complete six 30-minut…

This study builds a long-term bank of medical information and tissue samples (blood, liver, lung) from people with Alpha-1 Antitrypsin Deficiency. Up to 5,000 participants can join, and there are no restrictions on who can enroll. The goal is to provide researchers with resources…

This study is creating a large database of medical information and biological samples (blood, urine, and cheek swabs) from 1,000 newborns with a type of brain injury called hypoxic-ischemic encephalopathy (HIE). The goal is to measure biomarkers in the blood that could help docto…

This study tests a computer system that uses routine hospital data to predict risks of complications after surgery. Researchers will compare the computer's risk scores to those made by surgeons and anesthesiologists for the same patients. About 200 healthcare providers will parti…

This study uses artificial intelligence to analyze video recordings of surgeons during operations. The goal is to identify poor posture and movements that lead to work-related muscle and joint pain. Researchers will also test if showing surgeons their own video and risk data help…