DNA test could Fine-Tune blood thinners for heart patients
NCT ID NCT06143709
First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 2 times
Summary
This registry studies how genetic information can help doctors choose the best antiplatelet medication for people who have had a heart stent procedure. Over 1,600 participants will provide DNA samples and be followed for 12 months to track heart events and bleeding. The goal is to learn how to personalize therapy based on genetics and other patient factors.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- DNA sample collection
- What this could lead to
- If successful, this could help doctors personalize antiplatelet medications based on a patient's genetics, potentially reducing heart attacks and strokes while minimizing bleeding risks.
- What could go wrong
- This is an observational registry, not a treatment trial, so it won't directly test a new drug or therapy. Results may not lead to immediate changes in clinical practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
1,643 people
The number who actually took part.
- Started
-
Jul 2020
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The target patient population will be male or female adults (age 18 years), of any race or ethnicity, who undergo PCI and clinical CYP2C19 genotyping, and are treated with clopidogrel, prasugrel, or ticagrelor in addition to aspirin.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Age ≥18 years * Underwent percutaneous coronary intervention for any indication * Had clinical CYP2C19 genotyping * Treated with dual antiplatelet therapy including clopidogrel, prasugrel, or ticagrelor plus aspirin or * Treated with a combination of a P2Y12 inhibitor i.e. clopidogrel, prasugrel or ticagrelor plus an oral anticoagulant. Exclusion Criteria: * Managed surgically * Treated with thrombolysis within 48 hours
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Florida
Gainesville, Florida, 32609, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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