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Hidden blood vessel damage may predict heart surgery complications

NCT ID NCT02965339

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether patients with pre-existing endothelial dysfunction (damage to the inner lining of blood vessels) are more likely to develop vasoplegia (a dangerous drop in blood pressure) after cardiac surgery using a heart-lung machine. Researchers will measure various markers of endothelial function in adults undergoing coronary artery bypass or aortic valve surgery. The goal is to understand if pre-existing vessel damage contributes to post-surgery complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a link is found, it could help identify patients at higher risk for complications after heart surgery, allowing for closer monitoring or preventive measures.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The results may not lead to changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Expected to start

Nov 2016

An estimate. Start dates often move.

Finished

Mar 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients ≥ 18 years, operated on for cardiac surgical myocardial revascularization (CABG) or surgical correction of aortic valve. Consent signed.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients ≥ 18 years. * Patient operated on for cardiac surgical myocardial revascularization (CABG) or surgical correction of aortic valve. * Consent signed. Exclusion Criteria: * Standing arrhythmia. * Pregnant woman. * curative anticoagulation (warfarin, NANCO, heparin). * Patient under guardianship. * Patient Refused to participate. * Cardiac surgery without CPB. * bicuspid aortic valve. * Participation in another study. * preoperative sepsis. * Minor or major, under guardianship or trusteeship (art L1121-5, L1121-8 and L1122 1-2)

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Conditions

The condition(s) this trial relates to.

palsy Vasoplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endothelial dysfunction Vasoplegia

Contacts and locations

Locations

  • CHU De Caen

    Caen, Caen, 14000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.