Surgery gives new hope for hand movement after paralysis
NCT ID NCT05638191
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether nerve transfer surgery can help people with cervical spinal cord injury regain hand function. Forty participants who have already chosen to have the surgery will be followed for two years, with regular tests of hand strength, sensation, and movement. Their results will be compared to their own starting point and to similar patients who did not have surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nerve transfer surgery
- What this could lead to
- If successful, this surgery could restore meaningful hand opening and closing in people with tetraplegia, improving independence and quality of life.
- What could go wrong
- This is a small, early-stage study with only 40 participants. Not everyone may regain useful hand function, and surgery carries risks like infection or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2021
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patient referrals are ensured through established care pathways for upper-limb rehabilitation in SCI, including nerve transfer. Research objectives will be facilitated through already available institutional clinical and rehabilitation resources at each study site. Potential participants will be informed of the study directly by their treating physicians. The research study will be introduced by the PI or one of the co-Is of the study, who are also responsible for clinical care of all prospective participants.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Traumatic, motor-complete cervical SCI (AIS A or B) * Male or female, ages 18-70 * Consent and plan to undergo nerve transfer to restore grasp function in at least one limb * Motor grade 4-5 at C5 * Motor grade 0-1 at C8/T1 * Injury duration within 6 months at the time of surgery * English-speaking and cognitively intact * Able to provide informed written consent * Able to attend and comply with the testing protocols Exclusion Criteria: * Inability or unwillingness to participate in post-operative rehabilitation (in person or virtual) * Secondary complication of SCI (e.g., intractable neuropathic pain, edema, contracture) or major medical comorbidity (e.g., traumatic brain injury) that would independently influence response to surgery or ability to participate in rehabilitation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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GF Strong Rehabilitation Hospital
RECRUITINGVancouver, British Columbia, V5Z 2G9, Canada
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Kingston Health Sciences Centre
RECRUITINGKingston, Ontario, K7L 5G2, Canada
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QEII Health Sciences Centre
RECRUITINGHalifax, Nova Scotia, B3H 3A7, Canada
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Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, M4N 3M5, Canada
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