SPINAL CORD INJURIES

This study is testing whether epidural stimulation (a device placed near the spinal cord) can improve walking, standing, and bladder control in people who have had a spinal cord injury within the past year. The goal is to help participants take steps and better manage urination. …

This study tests a method to optimize settings for epidural spinal cord stimulation in people with complete paralysis from a spinal cord injury. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. The study enrolls 100 adults …

This early study tests a device that creates a 'neural bypass' to help people with severe spinal cord injuries regain movement and sensation in their hands and wrists. Up to 7 participants will use the system to try tasks like grasping, pinching, and pouring water. The goal is to…

This study tests a combination of spinal cord stimulation, a wearable robot suit, and resistance training to help people with complete spinal cord injury walk on their own. Twenty adults with paralysis from the chest down will train for months to see if they can improve walking s…

This study tests whether starting leg cycling within the first week after a traumatic spinal cord injury can reduce complications like pneumonia and pressure sores, and improve nerve recovery. About 102 adults with recent spinal cord injuries will take part. The goal is to see if…

This study tests whether a simple, at-home treatment using a blood pressure cuff can improve heart health in people with spinal cord injury (SCI). The treatment, called remote ischemic conditioning (RIC), involves briefly inflating the cuff to restrict blood flow, then releasing …

This study tests whether epidural electrical stimulation can help people with spinal cord injuries improve movement. Researchers will measure brain and muscle activity in 20 adults who are at least one year post-injury. The goal is to understand how the stimulation affects nerve …

This study tests whether short, mild breathing treatments with low oxygen can help prevent dangerous blood pressure swings in people with spinal cord injuries. The treatment aims to improve daily function and independence. The study involves 24 adults with chronic, incomplete spi…

This study tests a device that reads brain signals and stimulates the spinal cord below the injury, aiming to restore voluntary leg movement and walking in people with chronic spinal cord injury. Only 3 participants will be enrolled to check safety and basic effectiveness. The ap…

This study tests a device called the Networked Neuroprosthesis for the upper extremity (NP-UE) in people with cervical spinal cord injury. The goal is to see if it safely helps improve the ability to pick up, move, and release objects. The trial involves 13 participants and focus…

This study tests a fully implanted device that helps people with cervical spinal cord injury regain hand, reach, and trunk function. About 30 participants with injuries at the C5-C7 level will use the device to perform daily tasks. The goal is to see if the device improves indepe…

This study tests a new therapy that combines a brain-computer interface with spinal cord stimulation to help people with incomplete spinal cord injury walk better. The therapy reads brain signals and sends them to the spine to improve leg movement. The trial involves 12 adults ag…

This study tests a personal exoskeleton that lets people with spinal cord injury walk hands-free and without crutches. Ten adults with paralysis will train with the device over several sessions to see if it is safe and helps them move around. The goal is to improve mobility and i…

This study tests whether a non-invasive spinal cord stimulation device, used during arm-crank exercise, can help improve blood pressure and heart rate control in people with chronic spinal cord injury (at or above T6). Sixteen adults will receive either real or sham stimulation w…

This study looks at whether short periods of breathing low oxygen, combined with spinal cord stimulation and walking practice, can help people with chronic spinal cord injury walk better. It includes 60 adults aged 18 to 80 who can already walk a little. The goal is to see if thi…

This study tests an experimental drug called NVG-291 in 40 people with spinal cord injuries. The goal is to see if it can improve nerve signals and movement, like walking speed and hand function. Participants receive either the drug or a placebo, and neither they nor the doctors …

This study tests if an extra surgery called duroplasty can improve recovery after a severe spinal cord injury. Duroplasty opens the tough covering around the cord and adds a patch to give the swollen cord more space. About 222 adults with neck injuries will be randomly assigned t…

This early-stage study tests a single course of injections called EG110A for people with spinal cord injury who still have bladder leakage despite standard treatments. The goal is to see if the treatment is safe and can reduce incontinence episodes. Sixteen adults who use cathete…

This early study tests a new spinal implant system (ARC-IM Lumbar) in 8 people with chronic spinal cord injury who already have a spinal implant. The goal is to see if the new system is safe and helps them walk and move more easily, while also being simpler to use at home. The st…

This study tests a surgically implanted device called the ARC-IM System to help manage blood pressure instability in people with chronic spinal cord injury. About 60 participants will be randomly assigned to receive the active device or a sham treatment for 3 months, then all wil…

This study tests whether a special virus therapy (bacteriophages) is safe for spinal cord injury patients who have E. coli bacteria in their bladder without symptoms. About 30 adults will receive either the virus treatment or a placebo. The goal is to see if the therapy is safe a…

This study tests a brain-computer interface (iBCI) that reads movement-related brain signals to let people with severe paralysis (from ALS, spinal cord injury, or brainstem stroke) control a tablet computer just by thinking. The goal is to restore fast, natural communication usin…

This study tests whether a therapy called functional electrical stimulation (FES) can improve arm and hand movement in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove system to stimulate muscles while participants practice tasks. The goal i…

This study tests two surgical procedures to reduce additional damage after a severe spinal cord injury. Ten adults with recent spinal cord injuries will receive either a spinal fluid sac expansion alone or combined with a nerve graft. The goal is to see if these approaches are sa…

This study tests whether semaglutide, a common diabetes drug, works well for people with spinal cord injury (SCI) who also have type 2 diabetes. SCI increases the risk of diabetes, but standard treatments may not work the same. The study will measure how the drug affects blood su…

This early study tests the safety of implanting a spinal cord stimulator in people with neck-level spinal cord injuries who rely on ventilators to breathe. The goal is to see if the device can help them breathe more on their own. The study involves 12 adults who are at least one …

This study is testing a new, more detailed MRI sequence (3D FGAPSIR) to see if it can find spinal cord lesions that standard MRI might miss. About 200 adults with multiple sclerosis will get an extra 10-minute scan during their regular MRI. The goal is to improve detection and un…

This study tests whether playing a virtual reality walking game can help reduce nerve pain in adults with chronic spinal cord injury. Researchers will enroll 250 people who have had a spinal cord injury for at least a year and experience daily pain of 4 or higher on a 10-point sc…

This small study tests whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injury. Sixteen participants will receive the stimulation and be monitored for side effects and completion of t…

This study tests whether training the leg reflexes can reduce nerve pain in people with spinal cord injury. Researchers will enroll 15 adults who have had a spinal cord injury for at least a year and have nerve pain in their lower leg. Participants will attend about 50 sessions o…

This study tests whether a noninvasive spinal cord stimulation device can safely improve bladder, bowel, sexual, and heart function in people with spinal cord injury. About 60 veterans in Canada and Ukraine will receive either real or sham stimulation alongside standard rehab. Th…

This study is testing whether a device that sends mild electrical pulses to the belly muscles can help people with chronic spinal cord injury complete their bowel routine faster. Fifteen adults with injuries above the T11 level will use the device at home and track their bowel ma…

This study looks at whether a safe, non-invasive brain stimulation method called rTMS can help treat depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive rTMS daily for four weeks. The main goals are to check if…

This study looks at whether different physical therapy wound care methods—like pulsed water cleaning and electrical stimulation—can help heal pressure sores (bedsores) in people with spinal cord injuries. About 40 adults in rehab will be assigned to one of three treatment groups.…

This study tests whether a low-sugar diet and mild electrical stimulation to the legs can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Researchers will measure blood pressure changes in the lab and at home over several days. …

This study tests whether breathing low oxygen, combined with spinal cord stimulation and walking practice, can improve walking for people with chronic spinal cord injury. About 60 adults with some walking ability will take part. The goal is to see if this approach helps them walk…

This study tests whether electrical stimulation of the spinal cord can improve hand and arm movement in people with cervical spinal cord injuries. Twelve adults aged 22-65 will receive the stimulation while doing upper body exercises. The goal is to see if this approach can stren…

This study tests a new wheelchair design that lets users change gears, making it easier to push uphill or over carpet. Researchers will compare different gear settings to see which reduces strain and improves efficiency. Thirty manual wheelchair users will try the chair in variou…

This early-stage trial tests a new drug called EC5026 for nerve pain caused by spinal cord injury. About 36 adults with this type of pain will take either the drug or a placebo daily for 14 days. The main goal is to check if the drug is safe and tolerable, while also seeing if it…

This study tests whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain in people with spinal cord injury. About 63 adults with spinal cord injury and chronic neuropathic pain will receive either real rTMS or a sham (fake…

This study tests a reflex training system to help people with chronic spinal cord injury walk faster and farther while reducing leg spasticity. Researchers will enroll 25 participants who have had a spinal cord injury for at least one year and can walk at least 10 meters with ass…

This study tests whether combining a powered exoskeleton (a robotic leg brace) with functional electrical stimulation (small muscle zaps) can improve walking speed in people with chronic spinal cord injury. About 34 participants with incomplete spinal injuries will be randomly as…

This study tests a new method to dose repetitive transcranial magnetic stimulation (rTMS) for treating depression in people with spinal cord injury (SCI). Standard rTMS dosing requires thumb movement, which many with SCI cannot do. The study will enroll 24 adults with SCI and maj…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain in people with spinal cord injury. Researchers will apply high-frequency rTMS to a brain area involved in pain processing and measu…

This study tests whether a gentle electrical stimulation applied to the skin over the spine (called transcutaneous spinal cord stimulation) is safe and can improve walking in children aged 3–16 with incomplete spinal cord injury. Twenty children will receive either real stimulati…

This study tests a smartwatch system that gives real-time activity tips to people with spinal cord injury. 196 adults who use wheelchairs will be split into two groups: one gets the smartwatch coaching plus a web program, the other gets the web program alone. The goal is to see i…

This study tests whether a 10-week online writing program, guided by a coach, can help adults with spinal cord injury process grief and improve emotional well-being. Researchers will measure changes in grief, stress, depression, sleep, and resilience. The study aims to enroll 60 …

This study explores whether a slow, controlled yoga breathing technique called Ujjayi can improve breathing, lung function, and sleep quality in people with spinal cord injuries. Twenty adults aged 18-60 who use wheelchairs will practice Ujjayi breathing for six weeks. Researcher…

This study tests a non-invasive spinal stimulation technique to help control blood pressure in people who had a spinal cord injury within the past month. Many of these individuals experience dangerous drops in blood pressure when sitting up, causing dizziness and nausea that can …

This study is testing a wearable robotic hand orthosis called MyHand-SCI to help people with C6-C7 spinal cord injury improve hand function. The device is designed to assist with grasping and daily tasks. Researchers will enroll 40 participants to evaluate how usable and helpful …

This study tests whether synchronizing brain and spinal cord stimulation can make hand exercise more effective for people with chronic cervical spinal cord injury. The goal is to strengthen nerve connections and improve hand function. Twelve participants will undergo up to 53 ses…

This study is testing whether sildenafil (the drug in Viagra) can reduce urine leakage in people with spinal cord injuries. About 24 adults with spinal cord injury who have at least 3 leaks per week will take sildenafil or a placebo for 4 weeks and track their leaks in a diary. T…

This pilot study tests whether adding a gentle electrical stimulation to the spinal cord (tSCS) can make robotic arm training work better for people with chronic spinal cord injuries. Six to eight adults with neck-level injuries will first do robotic training alone, then robotic …

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests whether playing a virtual reality walking game can reduce nerve pain in adults with incomplete spinal cord injury. Researchers will enroll 48 people who have had daily pain of at least 4 out of 10 for three months or more. Participants will use a VR headset to pl…

This study tests whether a gentle electrical stimulation of the spinal cord, combined with breathing exercises, can improve lung function in people with chronic spinal cord injury. About 36 adults will be split into three groups: breathing training alone, stimulation alone, or bo…

This study is testing whether a non-invasive spinal stimulation technique, combined with walking rehabilitation, can reduce muscle stiffness and improve leg strength and walking ability in people with incomplete spinal cord injury. Ten adults with stable, incomplete spinal cord i…

This study is testing whether a noninvasive electrical stimulation applied to the lower back can reduce spasticity (involuntary muscle activity), improve muscle strength, and lessen pain in people with spinal cord injury. About 36 participants will attend sessions over 2-3 weeks,…

This study is testing whether a mobile health app can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury better manage their health and improve their quality of life. About 160 participants aged 12 and older who li…

This study tests whether a combination of electrical spinal cord stimulation and breathing exercises can improve respiratory function in people with chronic spinal cord injury. Researchers will enroll 30 adults with a spinal injury at or above the chest level who have significant…

This study looks at a new method called 'telefitting' to fine-tune spinal cord stimulators for people with chronic back or leg pain. Participants will try different stimulation settings without knowing which one they are using, and a smart algorithm will pick the best option. The…

This study tests whether deep brain stimulation (DBS) can improve walking in people with spinal cord injury who still have some movement but cannot walk well on their own. Six adults aged 22 to 70 who have been injured for at least one year will receive DBS to a brain area called…

This study is testing a wearable robotic arm exoskeleton to help people with spinal cord injuries improve their arm and hand function. Nine participants will use the device for 45-minute sessions, 3-4 times a week for 12 weeks, alongside their usual care. Researchers will measure…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study tests whether combining body illusions (tricks that change how you perceive your body) with mild brain stimulation can reduce nerve pain and improve sensation in people with spinal cord injury. Researchers will enroll 30 adults with long-lasting neuropathic pain. The g…

This study tests if mild electrical stimulation to a nerve in the leg (TTNS) can help people with recent spinal cord injuries maintain bladder capacity and control. Researchers will enroll 120 adults with injuries at level T9 or above. The goal is to see if this non-invasive trea…

This study tests whether adding a non-invasive spinal cord stimulation technique (TSCS) to standard rehabilitation can improve arm and hand function in people with a recent spinal cord injury. 18 adults with cervical-level injuries will receive either real or sham stimulation dur…

This study looks at how the body controls blood pressure after a spinal cord injury and whether spinal cord stimulation can improve that control. Researchers will also check how stimulation affects heart function and the immune system. The study involves 80 adults aged 18-50 with…

This study looks at whether starting a special walking therapy (body weight supported treadmill training) at different times within the first 6 months after a spinal cord injury changes how well people recover. About 108 people with recent spinal injuries will be randomly assigne…

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical muscle stimulation. Researchers will check blood and spinal fluid for biomarkers to decide whether to start the program r…

This study is testing a noninvasive technique that uses mild electrical pulses on the skin over the spine to see if it can improve arm and hand function in people who have had a stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement in 30 ad…

This study compares two different robotic leg exoskeletons to see how they affect walking and user comfort in people with spinal cord injuries. Six participants with mid-back injuries who cannot walk will test both devices. The goal is to learn which exoskeleton works best for wa…

This study is testing whether a new robotic exoskeleton called TWIICE Rise is safe and practical for people with spinal cord injuries to use for walking. The study involves 15 participants and will take place in a clinic, at home, and in the community. The goal is to see if the d…

This study looks at how fast the bladder is filled during a test affects a condition called autonomic dysreflexia (sudden high blood pressure) in people with spinal cord injuries. Researchers will compare two filling speeds in 30 participants to see which triggers symptoms sooner…

This study aims to see if a specially designed education module helps people with spinal cord injury learn about their increased risk for heart disease, obesity, and related health problems. Researchers will enroll 250 adults aged 18-70 with spinal cord injuries and measure chang…

This study looks at whether giving gabapentin (a nerve pain medication) within 5 days of a spinal cord injury is practical. Researchers want to see if they can recruit enough people, get them to take the drug as directed, and keep them in the study. It involves 42 adults with any…

This study looks at how spinal cord stimulation combined with training can change the way nerves work in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants. The goal is to understand how these changes help imp…

This study follows 35 people who recently had a spinal cord injury to see how their gut bacteria change over the first year. Researchers will collect blood, stool samples, and bowel function surveys at the start, 6 months, and 12 months. The goal is to understand how the gut micr…

This study aims to understand why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests, brain activity measurements, and body responses like sweating and heart rate to learn more. The study involves 300 adults with spinal cord injuries or per…

This study explores whether a brain-computer interface (BCI) can help people with motor disorders, like spinal cord injury or stroke, control assistive devices just by thinking about moving. Researchers will use electrical stimulation to train the brain and improve BCI accuracy. …

This study looks at why men with spinal cord injury have a higher risk of heart attacks and strokes. Researchers will test blood vessel function in 48 men with recent spinal cord injury who have low or normal testosterone levels. The goal is to understand how low testosterone may…

This early-stage study tests a brain-computer interface (BCI) in up to 2 people who have lost the ability to speak due to conditions like spinal cord injury or ALS. The device is implanted in the brain to record signals when the person tries to speak, aiming to translate those si…

This study aims to understand how the autonomic nervous system—which controls things like blood pressure, skin blood flow, and bladder health—is affected after spinal cord injury. Researchers will perform lab tests and have participants wear a smartwatch to track skin sweat, hear…

This study looks at how brief periods of breathing low oxygen (intermittent hypoxia) might improve movement and walking in people with chronic spinal cord injury. Researchers will measure changes in walking endurance and leg strength in 44 adults with incomplete injuries. The goa…

This study tests whether a custom smartphone app and e-coaching can help people with spinal cord injury follow exercise guidelines. Researchers will first gather input from users and clinicians, then test the app's usability, and finally run a trial to see which coaching approach…

This study tests a brain implant that may allow people with paralysis (from spinal cord injury, ALS, or similar conditions) to control a computer cursor or other devices using just their thoughts. The main goal is to check the device's safety and see if it works as a proof of con…

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study 225 people with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity below the inju…

This study interviews adults with spinal cord injuries and neurogenic bladder, along with their caregivers, to learn about their experiences with different urinary treatments. The goal is to understand what works best for them and what challenges they face. Researchers hope these…

This early-stage study tests whether a brain implant can safely help people with severe paralysis (from ALS, spinal cord injury, or similar conditions) control a computer cursor or speech device just by thinking. Only 3 participants will be enrolled, and the main goal is to check…

This study looks at whether a very intensive arm and hand training program, started within 13 weeks of a cervical spinal cord injury, can help the brain and nerves adapt and improve movement. Researchers will measure changes in brain activity, nerve signals, and arm function in 4…

This study watches how the body controls blood pressure after a spinal cord injury. Researchers will track changes over time to see if they can predict future medical issues. About 18 adults with recent or long-term injury will take part. The goal is to better understand risks, n…

This study looks at a part of the brain called the reticulospinal system, which helps control movement like walking and reaching. Researchers will use loud sounds and motion tracking to measure how this system works in healthy people and in those with spinal cord injuries. The go…

This study tests whether short, repeated sessions of breathing low-oxygen air can improve breathing and other motor functions in people with chronic spinal cord injury. Researchers will also look for genetic markers that might predict who benefits most. About 62 adults with spina…

This study uses MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will compare people with recent or long-term injuries to healthy volunteers. The goal is to understand recovery and find markers that predict how symptoms will progress. …

This study looks at how spinal cord injury (SCI) may damage the cells lining blood vessels, increasing the risk of heart attacks and strokes. Researchers will measure blood vessel function in 40 adults with and without SCI. The goal is to understand the underlying causes so bette…

This study looks at how spinal cord injury changes the nerves and lining of the gut. Researchers will take small tissue samples from the colon of 40 people with spinal cord injury during a routine colonoscopy. The goal is to understand these gut changes and find new ways to treat…