SPINAL CORD INJURIES

This study is testing a brain implant system to help people who have lost the ability to speak due to conditions like ALS, spinal cord injury, or stroke. The implant reads brain signals related to speech, aiming to let participants control a computer to communicate with their tho…

This study is testing if a simple, at-home treatment using a blood pressure cuff can improve heart and metabolic health in people with spinal cord injuries (SCI). Researchers want to see if repeatedly inflating the cuff on an arm or leg for short periods is safe, doable, and help…

This is an early safety study testing whether a small electrical stimulator implanted in the neck can help people with severe cervical spinal cord injury breathe better. The study will enroll up to 12 adults who are dependent on a ventilator to breathe, at least one year after th…

This study is testing a small, implanted device called a neuroprosthesis to help restore hand and arm function in people with cervical spinal cord injuries. The device stimulates nerves to allow participants to pick up, hold, and release objects. Researchers aim to see if this te…

This study is testing whether a combination of electrical spinal cord stimulation and breathing exercises can help improve respiratory function in people with chronic spinal cord injuries. Researchers will enroll 30 adults with stable, non-progressive injuries to measure changes …

This small pilot study is testing whether gentle electrical stimulation of the ear's vagus nerve is safe for people with chronic spinal cord injuries. Researchers want to see if this non-invasive stimulation might help improve heart health and blood sugar control in this populati…

This study is testing an investigational drug called NVG-291 to see if it can help improve nerve signaling and function in people with spinal cord injuries. It will enroll 40 adults with recent (subacute) or long-term (chronic) cervical spinal cord injuries to measure changes in …

This study is testing a tiny brain implant that could help people who have lost the ability to speak due to conditions like ALS, stroke, or spinal cord injury. The device reads brain signals when a person tries to talk and translates them into computer-generated speech. Researche…

This study is testing a new spinal implant system designed to help people with chronic spinal cord injury walk better and perform daily activities more easily. Eight participants who already have spinal implants will receive upgraded equipment to see if it improves their leg move…

This study is testing whether a breathing therapy called acute intermittent hypoxia can improve breathing strength in people with chronic spinal cord injuries. Participants will undergo sessions where they briefly breathe low-oxygen air, combined with breathing muscle training, t…

This study is testing if the diabetes and weight-loss drug semaglutide (Ozempic) works well for people who have both a spinal cord injury and type 2 diabetes. About 50 participants will receive either the real drug or a placebo injection once a week for 24 weeks. Researchers will…

This study is testing whether a combination of spinal cord stimulation, a wearable robot suit for walking, and strength training can help people with severe spinal cord injuries regain the ability to walk on their own. Researchers will compare two groups over 12 months: one using…

This study is testing whether a mild, non-invasive electrical stimulation applied to the spine can boost the benefits of walking rehabilitation for people with chronic, incomplete spinal cord injuries. Eighteen participants will receive either the real stimulation or a sham (fake…

This early-stage study is testing an experimental device called a 'Neural Bypass System' to help restore hand and wrist movement and sensation in people with paralysis from a cervical spinal cord injury. Up to seven participants will have tiny electrode arrays surgically implante…

This study is testing a fully implanted device called a neuroprosthetic system to help people with mid-level neck spinal cord injuries regain movement and function. The device aims to restore control over hand grasp, arm reach, trunk stability, coughing, and bladder function. Res…

This study is testing whether a surgically implanted device that delivers mild electrical stimulation to the spinal cord can help people with paralysis from spinal cord injuries regain movement. Researchers aim to see if this stimulation can help retrain blocked nerve circuits an…

This study is testing whether a therapy called functional electrical stimulation (FES) can help restore arm and hand function in people with spinal cord or peripheral nerve injuries. Researchers will use a device called MyndMove to deliver gentle electrical pulses to nerves and m…

This study is testing if combining two therapies—a powered robotic exoskeleton suit and functional electrical muscle stimulation (FES)—is better than the exoskeleton alone for people with chronic spinal cord injury. It aims to see if this combination improves walking speed, endur…

This study is testing whether combining brief periods of breathing low oxygen with spinal stimulation and walking training can help people with chronic spinal cord injuries walk better. Researchers want to see if this three-part approach improves walking speed, endurance, and str…

This small pilot study is testing whether a specific surgical technique can help minimize additional damage to the spinal cord after a traumatic injury. The surgery involves making a small opening in the spinal cord lining and sometimes adding a nerve graft to relieve pressure an…

This study is testing whether deep brain stimulation can help people with spinal cord injuries walk better. Researchers will implant a small device in the brain to deliver electrical pulses to a specific area involved in movement. The trial involves 6 participants with incomplete…

This study is testing whether a surgically implanted device that delivers mild electrical stimulation to the neck spinal cord can help people with spinal cord injuries regain control of their arms and hands. Twelve participants will have the device implanted and undergo intensive…

This study is testing whether starting the medication gabapentin very early after a spinal cord injury might help improve long-term recovery of movement and body functions. It will enroll 42 adults who recently suffered a spinal cord injury to see if it's practical to run a large…

This study is testing a new way to potentially improve hand function for people with chronic spinal cord injuries in the neck. Researchers want to see if carefully timed electrical stimulation to the brain and spinal cord, given during hand exercises, can help strengthen nerve co…

This early-stage study is testing a new drug called EG110A, given as injections into the bladder wall, for adults with spinal cord injuries who experience frequent urine leaks. The main goals are to see if the treatment is safe and to find the right dose. Researchers will also ch…

This UK trial is testing whether adding a surgical step called 'duroplasty' to standard spine surgery helps people recover better from a severe spinal cord injury in the neck. Duroplasty involves opening the tough membrane around the spinal cord to give the swollen cord more spac…

This study is testing whether a new therapy that combines a brain-computer interface with spinal cord stimulation can help people with incomplete spinal cord injuries walk better. Researchers will work with 12 participants who have some leg movement to see if this technology impr…

This study is testing whether a breathing treatment called mild intermittent hypoxia can help prevent dangerous blood pressure swings in people with spinal cord injuries. Researchers will have 24 participants with spinal cord injuries and sleep breathing problems try this treatme…

This study is testing whether a combination of breathing exercises and gentle electrical stimulation to the spinal cord can improve lung function in people with chronic spinal cord injury. Researchers aim to see if this combined approach works better than either treatment alone. …

This study is testing a brain implant system called BrainGate2 to see if it's safe and if it works. People with paralysis from conditions like spinal cord injury or ALS have a small sensor placed in their brain. The main goal is to see if they can use their thoughts to control a …

This study aims to find the best time to start a special walking therapy after a spinal cord injury. Researchers will compare starting the therapy within 60 days, 3 months, or 6 months after injury to see which timing leads to the best walking recovery. The therapy involves walki…

This study is testing whether repeatedly breathing low oxygen levels for short periods can help improve walking and strength in people with chronic spinal cord injuries. Researchers want to understand how this 'intermittent hypoxia' treatment works and whether combining it with w…

This study is testing whether a non-invasive spinal stimulation device can help people with recent spinal cord injuries regain arm and hand function during their hospital rehabilitation. Eighteen participants will receive either real or placebo stimulation along with their standa…

This study is testing whether starting intensive arm and hand training very early after a neck-level spinal cord injury can help improve function. Researchers want to see if this specific training can encourage the nervous system to rewire itself. They will measure changes in the…

This study is testing a new implant system that creates a direct link between the brain and spinal cord to help people with chronic spinal cord injury regain control of their leg movements. The system reads brain signals for movement and translates them into electrical stimulatio…

This study is testing a new type of MRI scan to see if it can better find and describe spinal cord injuries in people with multiple sclerosis (MS). Researchers will compare the new 10-minute scan to standard MRI scans in 200 adult participants. The goal is to see if the new scan …

This study is testing whether a specific type of slow, controlled yoga breathing called Ujjayi can help people with spinal cord injuries. Twenty participants will learn and practice this breathing technique for six weeks. Researchers will measure if it improves their breathing pa…

This study is testing whether a combination of three treatments can help improve walking ability in adults with chronic spinal cord injury. The treatments involve briefly breathing air with low oxygen levels, receiving mild electrical stimulation to the spine, and doing walking t…

This study is testing whether playing a virtual reality walking game can help reduce chronic nerve pain in adults with incomplete spinal cord injuries. Researchers believe the VR experience may correct a mismatch between what the brain expects and what the body feels, which could…

This study is testing whether a combination of non-invasive spinal cord stimulation and walking rehabilitation can help people with incomplete spinal cord injuries. Researchers want to see if this approach reduces muscle stiffness and improves leg strength and walking ability. Th…

This study is testing whether training spinal reflexes can help improve movement in people with chronic spinal cord injuries. Researchers are recruiting 25 people with leg spasticity to use a special reflex training system over about 45 visits during 6 months. The goal is to see …

This study is testing whether a combination of visual body illusions and a gentle, non-invasive form of brain stimulation can help reduce chronic nerve pain in people with spinal cord injuries. Researchers want to see if this approach can lessen pain severity and improve daily li…

This study is testing a new method to determine the correct dose for a non-invasive brain stimulation treatment (rTMS) for depression in people with spinal cord injuries. The standard dosing method requires a thumb movement, which many people with these injuries cannot perform. R…

This study is testing whether gentle electrical stimulation of abdominal muscles can help people with chronic spinal cord injuries manage their bowel function more efficiently. Researchers will measure whether this approach reduces the time needed for bowel routines and improves …

This study is testing whether a special mobile app system can help people with chronic conditions like spinal cord injury or cerebral palsy better manage their daily self-care. The app sends reminders for tasks like medication, bladder routines, and skin checks, and lets users re…

This study is testing whether a non-invasive brain stimulation treatment called rTMS is safe and helpful for reducing depression in people with spinal cord injuries. Fourteen participants with depression and a cervical or thoracic spinal cord injury will receive rTMS treatment fi…

This small pilot study is testing whether a combination of non-invasive electrical spinal cord stimulation and robotic arm/hand training can improve upper limb function more than robotic training alone. It involves 6-8 people with chronic, incomplete spinal cord injuries in the n…

This study is testing whether sildenafil, the drug commonly known as Viagra, can help reduce urine leakage in adults with spinal cord injuries. Researchers will enroll 24 participants to take either sildenafil or a placebo pill for four weeks each, tracking how many leakage episo…

This study is testing a new rehabilitation program to help people recover walking ability after a recent spinal cord injury. Researchers will first test participants' blood and spinal fluid to find the best time to start a 12-week program of walking downhill on a treadmill while …

This study is testing whether a non-invasive brain stimulation therapy can reduce chronic nerve pain for people with spinal cord injuries. Researchers will compare two different stimulation targets in the brain against a placebo treatment. The goal is to see if this therapy can e…

This study is testing whether a non-invasive electrical patch placed on the back can help improve bladder, bowel, and sexual function for people with spinal cord injuries. It will involve 60 participants, including Ukrainian war veterans, who will receive either the real stimulat…

This study is testing a non-invasive method to help people with chronic spinal cord injury who experience dangerous drops in blood pressure when they sit up, a condition causing dizziness and fatigue. Researchers will use gentle electrical stimulation on the skin over the spine w…

This study is testing whether playing an immersive virtual reality walking game can reduce chronic nerve pain in adults with complete spinal cord injuries. Researchers believe the game may help by creating a visual illusion of walking, which could correct a mismatch in brain sign…

This study is testing a wearable robotic arm device to see if it helps people with spinal cord injuries improve their arm and hand function during rehabilitation. Nine patients will use the device for 12 weeks alongside their usual therapy. Researchers will measure changes in arm…

This study is testing a smartwatch app designed to help people with spinal cord injuries be more physically active. The app provides personalized, real-time feedback and activity suggestions. Researchers want to see if using this app along with a standard online activity program …

This study is testing whether a non-invasive magnetic brain stimulation therapy can reduce chronic nerve pain in people with spinal cord injuries. It will involve 60 participants who have had pain for at least six months. The therapy targets a specific brain area to see if it eas…

This study is testing a new manual wheelchair design that works like a multi-speed bicycle. It aims to reduce shoulder pain and strain for people who use wheelchairs due to spinal cord injuries. Researchers will have 30 veterans try different gear settings to see which makes push…

This study is testing a wearable robotic glove called MyHand-SCI, designed to help people with spinal cord injuries in their neck regain hand function. Researchers will work with 40 participants to see if the device is easy to use and helpful for daily tasks. The goal is to gathe…

This study is testing if a gentle, non-invasive electrical stimulation on the spine can safely raise and stabilize low blood pressure in people who have had a recent spinal cord injury. It aims to help these individuals avoid dizziness and nausea when sitting up, which currently …

This study is testing a noninvasive, skin-surface electrical stimulation applied to the lower back and stomach to see if it can reduce painful muscle stiffness (spasticity), improve leg strength, and lessen pain in people with spinal cord injuries. Researchers will compare differ…

This study is testing a small brain implant that reads movement signals from the brain. The goal is to help people who are paralyzed from conditions like spinal cord injury, stroke, or ALS control a tablet computer for communication. The main focus is on checking if the implant i…

This study is testing a non-invasive treatment called transcutaneous spinal cord stimulation (TSCS) for children with spinal cord injuries. It aims to see if placing gentle electrical pads on the back, combined with walking practice, is safe and can improve leg strength and walki…

This study is testing a new oral medication called EC5026 to see if it is safe and tolerable for people with chronic nerve pain caused by a spinal cord injury. Researchers will enroll 36 adults who have had this pain for over a year and have not gotten enough relief from other st…

This study is testing whether a 10-week online writing program, guided by a coach, can help adults with spinal cord injury cope with grief and emotional distress. Researchers will enroll 60 participants to see if writing about their feelings reduces grief, stress, and depression …

This study is testing whether training leg reflexes can reduce chronic nerve pain in people with spinal cord injuries. Researchers are recruiting 15 people with this type of pain to participate in about 50 training sessions over 6.5 months. The goal is to see if this specific tra…

This study is testing whether a robotic exoskeleton called TWIICE Rise is safe and practical for helping people with spinal cord injuries walk. Researchers will work with 15 participants to see how well they can use the device in different settings, including clinics, homes, and …

This study is testing a surgically implanted device called the ARC-IM System to see if it can safely help manage unstable blood pressure in people with chronic spinal cord injuries. The device sends electrical stimulation to the spinal cord. For 3 months, 60 participants will be …

This study is testing whether spinal cord stimulators can be adjusted remotely to better control chronic back and leg pain. Fifteen adults already scheduled to get a spinal cord stimulator will try different stimulation patterns through a smartphone app over four months, reportin…

This study aims to understand how the community of bacteria in the gut changes during the first year after a spinal cord injury. Researchers will follow 35 people with recent injuries, collecting stool and blood samples at three points over a year. The goal is to see if changes i…

This study aims to better understand a dangerous condition called autonomic dysreflexia (AD), where blood pressure spikes dangerously high. Researchers will observe 30 people with spinal cord injuries during a standard bladder test. They will compare how fast the bladder is fille…

This study aims to better understand how spinal cord injuries affect automatic body functions like blood pressure control, heart rate, and temperature regulation. Researchers will perform lab tests and have participants wear smartwatches to track these functions in 69 people with…

This study aims to understand how a specific part of the brain helps control movement, especially in people recovering from a spinal cord injury. Researchers will compare movement and muscle responses in 248 people, including healthy volunteers and those with recent or long-term …

This study aims to understand why severe nerve pain develops after a spinal cord injury. Researchers will measure pain signals and nervous system responses in 300 participants, including people with recent or long-term injuries and healthy volunteers. The goal is to learn how the…

This study aims to understand why people with spinal cord injuries have a higher risk of heart attacks and strokes. Researchers will compare blood vessel function in men with recent spinal injuries who have low versus normal testosterone levels. By measuring how well blood vessel…

This study aims to understand how the brain and spinal cord change their structure and function after a spinal cord injury. Researchers will use MRI scans to compare 450 people with recent or long-term injuries to healthy volunteers. The goal is to find patterns in these brain ch…

This study aims to learn from patients and caregivers about their experiences with different bladder treatments. Researchers will interview people who have used specific bladder solutions to understand what works well, what challenges they face, and what they prefer. The goal is …

This study aims to understand why people with spinal cord injuries have a higher risk of heart attacks and strokes. Researchers will measure how well blood vessels relax and increase blood flow in 40 adults, comparing those with and without spinal cord injuries. They will also te…

This study aims to understand how people with spinal cord injuries respond to flu and COVID-19 vaccines compared to people without injuries. Researchers will measure blood markers and antibodies in 140 participants to see if injury severity affects immune protection. The goal is …

This Mayo Clinic study aims to understand how the body's automatic functions like blood pressure control change after spinal cord injury. Researchers will monitor 18 people with recent or long-standing spinal cord injuries to see if these changes can predict who might develop add…

This study aims to understand how spinal cord stimulation affects blood pressure control, heart function, and immune response in people with spinal cord injuries. Researchers will measure these body functions in 80 participants, including people with spinal cord injuries and heal…

This study aims to compare two different types of robotic walking suits (exoskeletons) for people who cannot walk due to a spinal cord injury. Researchers want to see which type is easier to use, less tiring, and better for walking. Six participants will try both suits during sev…

This study aims to understand how the brain and spinal cord change their structure and function after a spinal cord injury. Researchers will use advanced MRI scans and other tests on 225 participants with recent or long-term injuries to create detailed maps of nerve activity and …

This study is testing whether an educational program helps people who recently had a spinal cord injury understand their increased risks for heart disease, obesity, and diabetes. Researchers will enroll 250 adults within 4 months of finishing their initial rehab. The main goal is…