One-Week brain zaps could Fast-Track PTSD recovery
NCT ID NCT06544408
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a week of accelerated brain stimulation (25 sessions over 5 days) can quickly reduce PTSD symptoms. It involves 132 adults with PTSD, including those with traumatic brain injury. The goal is to see if this fast-paced treatment works better than a placebo version.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 132 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion: 1. Adults age 18 years to 65 years old. 2. Meets DSM-5 criteria for PTSD with a PCL-5 score \> 33 3. No changes in psychotropic medication (if taking psychotropic medication) and/or changes in supportive psychotherapy for 1 month prior to initial visit; and clinically appropriate to maintain stable treatment regimen for duration of trial. 4. Clinically competent to give informed written consent and ability to understand study procedures and to comply with them for the entire length of the study Exclusion: 1. Medical contraindication for neuromodulation (e.g., ferrous metal in head, seizure disorder, brain tumor, stroke, aneurysm, multiple sclerosis, etc.). 2. Active substance use disorder in last 3 months or any current substance use that puts the participant at increased risk or significant impairment. 3. Dementia or other cognitive disorder making unable to engage in treatment. 4. Any history or diagnosis of Schizophrenia, Schizoaffective Disorder, Delusional Disorder or other psychotic illness that precludes safe participation in trial. 5. Suicidal risk that precludes safe participation defined as clinical impression that the participant is at significant risk for suicide. 6. OCD cannot be the primary disorder but can have OCD symptoms. 7. Inability to stop taking any medication that significantly lowers the seizure threshold (e.g., tricyclic antidepressants, clozapine, etc.) 8. Current, planned, or suspected pregnancy 9. Unstable medical conditions or any current medical condition that could preclude being able to safely participate in TMS treatment (e.g., unstable metabolic abnormality, unstable angina, etc.) 10. Severe Traumatic Brain Injury 11. We will exclude non-English speakers because of the need for rapid communication during the delivery of treatments. 12. Significant ongoing litigation or claims that impact research activities, as determined by the research study team. (Research may especially be impacted when mental health or pain is being evaluated for litigation or claims, such as civil and criminal cases, disability claims and worker's compensation). 13. Prior known active TMS of dorsolateral prefrontal cortex or dorsomedial prefrontal cortex or electroconvulsive therapy (ECT) -
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Florida State University
RECRUITINGTallahassee, Florida, 32306, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a web program rebuild memory after brain injury?
- Can training hospital staff in Trauma-Informed care make childbirth safer?
- Why a simple fall can cause brain bleeding in older adults
- Bedside ultrasound could flag hidden brain injury decline
- Scientists probe brain's reward system in mental illness