POST-TRAUMATIC STRESS DISORDER

This study is testing if two non-drug therapies can calm an overactive nervous system in veterans with PTSD, which is linked to higher heart disease risk. One therapy uses a breathing device to guide slow breathing, and the other uses mild electrical stimulation on the neck. Rese…

This project is testing a new, brief therapy for Post-Traumatic Stress Disorder (PTSD) in Ukraine, where many people are suffering from war-related trauma. The therapy, called the RTM Protocol, aims to reduce distressing symptoms in just 3-5 sessions without requiring patients to…

This study aims to find safe and effective medications to help control symptoms of Post-Traumatic Stress Disorder (PTSD). It will enroll 800 active-duty service members and veterans to test several different drugs against a placebo over 12 weeks. The trial uses a flexible design …

This study is testing whether involving a veteran's romantic partner in PTSD therapy leads to better recovery than standard individual therapy alone. It will enroll 420 post-9/11 veterans with PTSD and their committed partners across several VA medical centers. The goal is to see…

This study aims to find out which of two common sedative drugs is better for protecting brain function in infants and children who need a breathing machine in the intensive care unit. It will compare dexmedetomidine and midazolam in 372 young patients to see which one reduces del…

This study tests a stepped approach to make PTSD treatment more accessible and effective in regular medical care. It starts with a digital self-help program, then adds coaching or brief therapist-led treatments if needed. The goal is to help more people with PTSD get appropriate …

This study examines whether treating obstructive sleep apnea (using a positive airway pressure device) during a 28-day residential treatment program improves outcomes for Veterans with both PTSD and substance use disorder. Researchers will compare immediate treatment to a delayed…

This study is testing whether a combination of two treatments works better for veterans with PTSD. One treatment uses a magnet to gently stimulate a part of the brain linked to emotion control. The other is a brief, structured writing therapy about traumatic memories. Researchers…

This study is testing whether a medication called daridorexant, which is currently used for insomnia, can help control symptoms of Post-Traumatic Stress Disorder (PTSD). It will involve 200 active-duty service members and veterans. Participants will be randomly assigned to receiv…

This study is testing whether a computer-based working memory training program can help Veterans with PTSD better manage fear responses. 120 participants will complete either the real training or a placebo version over four weeks, with brain scans before and after. Researchers wa…

This study is testing whether a new medication called TSND-201 can help reduce symptoms of PTSD in adults. Researchers will compare two different doses of the medication against a placebo in 300 people who have had PTSD for at least 6 months and haven't gotten enough relief from …

This UCLA study is testing a personalized, non-invasive brain stimulation treatment for people who still have symptoms like headaches, dizziness, fatigue, and brain fog months after a concussion. Researchers will use MRI scans to map each person's brain and then apply magnetic pu…

This study is testing a new therapy designed specifically for military veterans and service members who have both post-traumatic stress disorder (PTSD) and a traumatic brain injury. The treatment involves individual counseling sessions that focus on managing PTSD symptoms without…

This study aims to find out if the medication fluoxetine is safe and effective at reducing symptoms of Post-Traumatic Stress Disorder (PTSD). It will involve 200 active-duty service members and veterans who have PTSD. Participants will be randomly assigned to receive either fluox…

This study aims to help veterans with PTSD get the most out of their therapy. It tests two methods to spot when someone is struggling with their current treatment and then compares two ways to help them: using special skills from their current therapy or discussing a switch to a …

This study is testing whether adding augmented reality (AR) to standard exposure therapy helps military personnel with PTSD. 40 veterans or active-duty members will be randomly assigned to receive either standard therapy alone or therapy enhanced with AR scenarios, like simulated…

This study is testing whether a single intravenous dose of a natural brain hormone called allopregnanolone can help people with PTSD. Researchers want to see if this medication helps the brain better process traumatic memories during a standardized laboratory procedure that measu…

This study is testing if a capsule made from lavender oil, called Silexan, can help reduce symptoms of Post-Traumatic Stress Disorder (PTSD). It will involve 278 adults with PTSD who will take either the Silexan capsules or a placebo (dummy pill) daily for 12 weeks, in addition t…

This study is testing whether a special computer-based brain training program can help people with anxiety, depression, or PTSD. Participants will be randomly assigned to use either the active training program or a less effective 'sham' version. Researchers will measure changes i…

This study is testing a new brain scanning technology to help personalize magnetic stimulation therapy for people with PTSD and traumatic brain injury. Researchers want to see if directly measuring brain activity with a special scanner can lead to more accurate treatment dosing t…

This study is testing whether a short, therapist-supported online therapy program can prevent post-traumatic stress disorder (PTSD) in people who have recently experienced a traumatic event. It will involve 360 people in Norway who are showing early PTSD symptoms about a month af…

This study is testing whether a breathing training program called 'cardiac coherence' can help prevent people from developing long-term PTSD after a recent traumatic event. It involves 44 people in France who have just experienced trauma and are showing acute stress. Participants…

This study is testing whether a gentle, non-invasive brain stimulation technique can weaken the formation of fear memories right after a distressing experience. Researchers at Emory University are enrolling 66 people to see if this approach can reduce the risk of developing Post-…

This study is testing whether a training program that teaches people to relax their muscles can help disaster survivors who have post-traumatic stress disorder (PTSD). Researchers will work with 50 adults who have PTSD after a disaster to see if the relaxation training reduces th…

This study is testing whether morning bright light therapy can improve sleep quality in veterans with traumatic brain injury or PTSD. Researchers will recruit 200 veterans to use a light box for 60 minutes each morning for four weeks. They'll track sleep patterns before, during, …

This small pilot study aims to see if a 16-week trauma therapy program delivered by video call is practical and acceptable for adults with PTSD or complex PTSD in Chile. It will enroll 13 participants from local mental health services to test the process and gather feedback. The …

This study is testing if a single injection near nerves in the neck, called a stellate ganglion block, can reduce the symptoms of PTSD. 80 adults with PTSD will be randomly assigned to receive either the real injection with a numbing medicine or a placebo injection with salt wate…

This study is testing whether daily cannabidiol (CBD) pills can help reduce symptoms of Post-Traumatic Stress Disorder (PTSD). It will involve 120 adults with PTSD, half of whom also have a mild traumatic brain injury (TBI). Participants will take either a 400mg CBD dose, an 800m…

This study is testing two different therapy programs to help female veterans who have experienced military sexual trauma or intimate partner violence, and who also have a history of brain injury. Researchers want to see which approach works better at helping participants manage t…

This study is testing a new behavioral therapy for combat veterans with PTSD. It uses very brief, hidden exposures to combat-related images, aiming to reduce fear without causing the emotional distress of traditional therapies. Researchers will compare brain activity and fear rat…

This study is testing whether a breathing exercise technique called heart rate variability biofeedback can help reduce persistent symptoms after concussion. The research involves 148 adults, including military veterans and civilians, who have had mild traumatic brain injuries and…

This study is testing whether a specific type of acupuncture can help reduce the distressing symptoms of Post-Traumatic Stress Disorder (PTSD). It will involve 75 active-duty military members and their families who have been diagnosed with PTSD. Researchers will measure changes i…

This study is testing a mobile app called Blueprint, designed to help people manage depression, anxiety, and PTSD after surviving a serious heart or lung condition in the hospital. Researchers will enroll 400 people from four hospitals and randomly assign them to use either the B…

This study is testing whether an 8-week virtual reality exercise program can help improve physical and mental health for women veterans. Researchers will compare 40 veterans who use the VR adventure games to a control group, measuring changes in activity levels, mood, stress, and…

This Stanford study is testing whether intentionally inducing dreams while under light anesthesia can help reduce the symptoms of Post-Traumatic Stress Disorder (PTSD). In this Phase 2 trial, 42 adults with PTSD will be randomly assigned to receive either a deep sedation designed…

This study is testing a digital program designed to help immigrant women who have experienced violence and are dealing with PTSD or depression. The program aims to teach coping skills, reduce stress, and improve safety and mental health. It will involve about 676 participants and…

This study is testing a new computer training program designed to help veterans who have both a mild brain injury and PTSD. The program teaches people to better recognize emotions in other people's faces and voices, and includes exercises to improve attention. Researchers want to…

This study is testing whether a smartphone app called OTX-601 can help reduce symptoms of post-traumatic stress disorder (PTSD) in adults. Researchers will compare the app against another digital program to see which works better at easing PTSD symptoms over 7 weeks. The study in…

This study aims to better understand how psychotherapy helps teenagers with Post-Traumatic Stress Disorder (PTSD). Researchers will interview 65 teens, aged 12-18, and their parents before and after therapy to learn about their personal experiences. The goal is to identify the ke…

This study aims to understand how a stay in an intensive care unit (ICU) affects a patient's mental health and overall quality of life after they go home. Researchers will survey 40 adult patients who spent more than two days in the ICU to measure their experience and check for s…

This study aims to understand *why* a proven talk therapy for PTSD works. Researchers will measure brain activity, heart rate, and other body signals in 15 people before, during, and after they complete a standard 10-session therapy. The goal is to identify the physical and menta…

This study aims to understand how sleep quality affects emotion processing and daily mood in teenagers with Post-Traumatic Stress Disorder (PTSD). Researchers will observe 180 teens, including some with PTSD and some without, to see if using a special headband to improve deep sle…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This study aims to find out if a person's reaction to a safe, brief carbon dioxide (CO2) breathing test can predict whether they will not respond to a common and effective talk therapy called exposure therapy. Researchers will give the test to 600 adults with conditions like anxi…