Alcohol and PTSD: study probes Brain's Risk-Taking pathways

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. Inclusion criteria for all participants: * between 21 and 60 years of age * having consumed at least 4 (men) or 3 (women) drinks on at least two occasions over the last year 2. Inclusion criteria for PTSD participants: \- Meeting diagnostic criteria for PTSD, confirmed by structured interview 3. For all subjects exclusion criteria include: * history of significant medical illness, particularly if possible changes in cerebral tissue * neurologic abnormality including significant head trauma (loss of consciousness of ≥5-min) * full Scale IQ \<85 * contraindication to MRI scanning * positive pregnancy test * severe alcohol use disorder * current severe cannabis use disorder * any current substance use disorder (other than alcohol, cannabis, or nicotine) * scores \> 15 on the alcohol Use Disorders Identification Test (AUDIT; part of phone screen) * ever being in an abstinence-oriented treatment program for alcohol use * reporting wanting to quit drinking but not being able to * any medical, religious, or other reasons for not drinking alcohol * history of heart attack, heart trouble, high blood pressure, diabetes, or liver disease * an adverse reaction to alcoholic beverages * reporting never consuming 4 (men) or 3 (women) or more drinks on at least two occasions over the last year * unwillingness to have a friend or family member drive them home after the alcohol administration sessions 4. Additional exclusion criteria for participants in PTSD and IPV-exposed but no PTSD groups: * not taking medications for \>4 weeks (i.e. participants must be stable on meds) * acute suicidality with intent 5. Additional exclusion criteria for participants in IPV-exposure but no PTSD group: \- history of PTSD 6. Additional exclusion criteria for healthy comparison subjects also include: * any prior psychiatric hospitalizations * lifetime history of a neurodevelopmental disorder, affective disorder, psychotic disorder, suicide attempt, or eating disorder * greater than 1 month of lifetime psychotropic medication