ALCOHOL DRINKING

This study tests whether a 30-day mobile health challenge can help adults who drink heavily reduce or stop alcohol use. Researchers will enroll 150 participants to see if the program is easy to use and effective. The goal is to help people gain control over their drinking habits.

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce the desire to drink and lower heavy drinking days in people with alcohol use disorder. About 86 adults who drink heavily will receive either real or fake (sham…

This study looks at how binge drinking affects blood pressure, blood vessel health, and nerve activity in people aged 50-64. It then tests whether 8 weeks of aerobic exercise can improve these measures. The goal is to find a non-drug way to reduce heart risks in this group.

This study tests a web-based program called Partners Connect for military couples where one partner drinks heavily. The goal is to help the concerned partner drink less and encourage the service member to seek help. About 744 couples will participate, comparing the online program…

This study tests a phone-based therapy called Acceptance and Commitment Therapy (ACT) to help people with HIV who drink too much. Researchers will compare ACT to a standard brief intervention in 300 adults. The goal is to see if ACT reduces alcohol use and improves symptoms of de…

This study aims to see if a short self-report questionnaire called T-ACE can correctly identify pregnant women who drink alcohol at risky levels. Researchers will compare the T-ACE results with a blood test that measures a biomarker of recent alcohol use. About 2,425 pregnant wom…

This study tests whether using mobile health (mHealth) tools helps find oral cancer and pre-cancer earlier than traditional screening methods. Over 5,000 adults in rural Varanasi, India, who smoke, chew tobacco, or drink alcohol will be screened. The goal is to improve early dete…

This study tests whether a motivational program can help pregnant women reduce alcohol use. About 600 pregnant women who recently drank alcohol will receive either a computer-based alcohol reduction program plus nurse support, or standard care. The goal is to lower alcohol-relate…

This study tests a prevention program for young adults (ages 18-30) who binge drink. The program uses motivational interviewing and other psychological techniques to help reduce heavy drinking. About 240 students will take part to see if the program works better than usual advice…

This study aims to prevent binge drinking and its consequences in about 3,000 US Air Force technical trainees. Participants will receive either the standard brief alcohol intervention or that plus automated text messages timed around when they first get access to alcohol off base…

This study looks at two ways to help young people ages 12-19 who already drink alcohol to cut back. One group gets a short web program, and the other gets that plus supportive text messages for 8 weeks. Parents can also use a free app to talk with their kids about drinking. The g…

This study tests a program that combines brief counseling with mobile technology to help young adults who drink heavily. The goal is to see if participants find the tools useful and easy to use, and if they help reduce drinking. About 90 people aged 18-25 who drink heavily will t…

This study tests whether a friendly chatbot app can help high-risk drinkers cut back on alcohol. About 220 adults who want to drink less will use the app for 4 weeks, and researchers will check their drinking habits after 16 weeks. The goal is to see if the app's motivational con…

This study tests whether watching a short video of moving black-and-white squares (called dynamic visual noise) can reduce alcohol cravings and drinking in college students who crave alcohol at least once a week. Over 7 days, participants either watch the moving video or a static…

This study looks at whether a single dose of a nutritional ketone ester drink can change how the brain responds to alcohol cues and reduce the urge to drink in people with alcohol use disorder. Twenty adults who drink heavily but are not seeking treatment will receive either the …

This study compares two ways to encourage young heavy drinkers to help others in sexual risk situations. One program focuses only on bystander skills, while the other adds alcohol reduction strategies. 450 participants aged 18-25 will complete online training, a virtual reality s…

This study looks at why young adults with bipolar disorder are more likely to develop alcohol use disorders. Researchers will use brain scans and alcohol response tests to track changes over two years in 100 people aged 21-26. The goal is to find early warning signs that could le…

This study looks at how a 4-week ketogenic diet changes the way the brain responds to alcohol. Twenty adults will follow the diet and complete three lab visits, including alcohol tolerance tests and brain scans. The goal is to understand if ketosis alters brain chemistry and alco…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study looks at how a specific gene (CHRNA5) affects the way people experience alcohol and how their brains respond to alcohol-related cues. Researchers will give alcohol to healthy adults aged 21-60, including both smokers and non-smokers, and use brain scans and self-report…

This study looks at how alcohol, cannabis, and certain medications impact falls and brain function in people with HIV. Researchers will enroll 100 participants from VA clinics to test a pharmacist-led intervention and gather feedback. The goal is to understand these risks and imp…

This pilot study looks at whether reducing alcohol and taking probiotics can improve thinking skills and brain energy use in healthy older adults (ages 65-84) who drink heavily. Participants will get counseling to drink less and take either a probiotic or a placebo pill. The goal…

This study looks at what happens when young adults drink Jägerbombs (a mix of energy drink and alcohol) compared to drinking alcohol alone during a binge-drinking session. Researchers will measure changes in reaction time, coordination, vision, and hangover symptoms. The goal is …

This study looks at how a single dose of a ketone drink or alcohol changes brain chemistry compared to no drink. Sixty adults will have three MRI scans after each condition. The goal is to measure brain chemicals like NAD, glutamate, and GABA. This is not a treatment study—it aim…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorder and healthy volunteers. Participants will complete tasks either inside or outside an MRI scanner to see how the brain works. The goal is to d…

This study is testing a computer program that uses interactive stories and artificial intelligence to help teenagers aged 15-17 who already drink alcohol make healthier choices. About 200 teens will use the program during their regular clinic visits. The goal is to see if the pro…

This study looks at how having PTSD might change the way people make decisions after drinking alcohol. Researchers want to understand why some people with PTSD develop alcohol problems. They will give 200 adults either alcohol or a placebo and use brain scans to see how their bra…

This study follows 1500 adults to understand how the COVID-19 pandemic has changed their drinking habits and stress levels. Participants complete surveys online or by phone over 2 years, reporting on alcohol use, mental health, and quality of life. No treatments or medications ar…