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Should you switch PTSD therapies? new study aims to find out

NCT ID NCT06957067

Symptom relief Sponsor: United States Department of Defense Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 2 times

Summary

This study compares two strategies for veterans struggling with Cognitive Processing Therapy (CPT) for PTSD: using CPT skills to work through challenges, or switching to a different therapy called Present Centered Therapy. The goal is to see which approach reduces dropout and improves PTSD symptoms, depression, and daily functioning. Researchers will track 280 veterans to find the best way to keep people engaged in treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive Processing Therapy (CPT) skills and Present Centered Therapy (PCT)
What this could lead to
If successful, this could help therapists know when to switch PTSD treatments to keep veterans in therapy and improve their symptoms.
What could go wrong
This is a behavioral study, not a drug trial, so results may be subtle. It is still recruiting and outcomes depend on individual responses to therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 280 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veterans interested in outpatient VA psychotherapy for PTSD * Meets DSM-5 criteria for PTSD * Be able to provide informed consent * Be willing to be randomized * Agree to not receive non-study psychotherapy for PTSD during study treatment (case management, supportive therapy/group, and concurrent substance use treatment are allowable) Exclusion Criteria: * Severe cognitive impairment * Current suicidal or homicidal intent with a specific plan * Uncontrolled psychotic or manic symptoms * A psychiatric medication change in the past month * A severe SUD as diagnosed by the DSM-5

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-traumatic stress disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • New Orleans VA Medical Center

    RECRUITING

    New Orleans, Louisiana, 70119, United States

  • Ralph H. Johnson VA Health Care System (Charleston VA)

    RECRUITING

    Charleston, South Carolina, 29401, United States

  • VA Houston Healthcare System

    RECRUITING

    Houston, Texas, 77030, United States

  • VA Phoenix Health Care System

    RECRUITING

    Phoenix, Arizona, 85012, United States

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