POST-TRAUMATIC STRESS DISORDER

This study followed 44 people with PTSD who had already completed a previous trial with the drug TSND-201 (methylone). Over 52 weeks, researchers checked their symptoms and safety each month. If symptoms returned, participants could get more treatment. The goal was to see if meth…

This study tested two online education programs to see if they could prevent stress-related conditions like PTSD, depression, and burnout in paramedics working during the COVID-19 pandemic in Singapore. 63 paramedics took part, completing 6 weekly online modules. The goal was to …

This pilot study tested the Safe and Sound Protocol (SSP), a listening therapy using specially filtered music, to see if it can reduce PTSD and anxiety symptoms. 45 adults from a therapy clinic took part, with some receiving SSP plus their usual therapy and others just usual ther…

This study looked at whether a simple aerobic exercise program could help earthquake survivors feel better and sleep more soundly. 82 adults living in temporary shelters were randomly assigned to either a supervised exercise group or a control group. The exercise group did modera…

This study tested if Written Exposure Therapy (WET) can be given virtually in a group setting to help military and police with PTSD. 29 people took part to see if the treatment was acceptable and if it reduced trauma symptoms. The goal was to understand if this approach is feasib…

This study tested whether a smartphone-based attention training program can reduce symptoms of post-traumatic stress disorder (PTSD). Over 1,300 adults with significant PTSD symptoms participated entirely from home, completing 14 sessions over two weeks. The goal was to see if tr…

This study tested a therapy called Acceptance and Commitment Therapy (ACT) to help veterans with PTSD improve their social support and relationships. 107 veterans took part. The therapy focused on helping them feel less isolated and more connected to family and friends. The goal …

This study looked at whether 6 months of supervised exercise can reduce PTSD symptoms and improve physical health in older veterans. About 80 veterans with PTSD took part. The goal was to see if regular exercise helps both mind and body.

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble readjusting to civilian life. The workshop taught practical skills like managing emotions, solving problems, and focusing attention. The goal was to help Veterans feel more connected to their…

This study tested whether minocycline, an antibiotic, could reduce the frequency and intensity of intrusive memories in people with PTSD or cocaine use disorder. 138 participants took the drug and reported changes in their memories using smartphone surveys. The goal was to see if…

This study tested a 9-week online group program called Trauma-Informed Goal Management Training (TI-GMT) to see if it helps people with PTSD improve their thinking skills and reduce symptoms. 33 adults from Ontario took part. The program teaches strategies to manage attention and…

This study tested a program called MOSAIC Plus for pregnant women and mothers of young children who have experienced intimate partner violence (IPV) and have symptoms of depression or PTSD. The program combines support from community advocates with therapy techniques to reduce th…

This study tested a new way of managing anxiety and depression in general practice. 302 adults with conditions like panic disorder, social anxiety, or PTSD were assigned to either a collaborative care model (where a care manager coordinates with the GP) or standard consultation. …

This study tested a drug called methylone in 62 adults with severe PTSD. Participants received the drug once a week for 3 to 4 weeks, then were followed for up to 8 weeks. The goal was to see if methylone safely reduces PTSD symptoms like flashbacks and anxiety. The trial is now …

This study tested a therapist-assisted self-management program for 80 veterans who had already completed trauma-focused therapy for PTSD and seen improvement. The goal was to help them maintain or further reduce symptoms, boost confidence in managing their condition, and cut down…

This study tested whether a natural probiotic (Lactobacillus rhamnosus GG) can reduce inflammation and improve PTSD symptoms in veterans. Researchers measured blood markers of inflammation, gut health, and PTSD severity. The goal was to see if this simple, safe supplement could o…

This small pilot study tested whether a therapy called written exposure therapy, done over video calls, could help prevent or reduce PTSD symptoms in women who had recently experienced a sexual assault. 30 women took part within a week of the assault. The study focused on whether…

This study tested whether methylone, a substance similar to MDMA, is safe and can help reduce PTSD symptoms. 79 adults with moderate to severe PTSD who had not improved with other treatments received either methylone or a placebo once a week for four weeks. Researchers measured c…

This study tested a 5-week group program called Rare Group Problem Management Plus (PM+) for parents or guardians of children with rare diseases. The program aims to help with stress, anxiety, depression, and emotional problems. Eight participants joined online sessions and compl…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health issues like PTSD and depression. The goal was to see if the workshop could reduce distress and help veterans readjust to civilian life. 176 veterans too…

This study looked at whether learning to train a future service dog, along with usual care, can improve symptoms of post-traumatic stress (PTS), anxiety, depression, and pain in military members and veterans. 156 participants with PTSD or mild traumatic brain injury took part. Re…

This study tested whether a simple technique called progressive muscle relaxation training can reduce symptoms of post-traumatic stress disorder (PTSD) in people affected by the February 6 Kahramanmaraş earthquake. 44 adults with PTSD took part. The training involves tensing and …

This study tested a type of talking therapy called Cognitive Processing Therapy (CPT) to help adults in Turkey who were struggling with PTSD, anxiety, and depression after the 2023 earthquakes. 36 survivors took part, with some receiving CPT and others getting usual care. The goa…

This study tested a racecar simulation program designed to help veterans with PTSD learn to manage stress and emotions. One veteran completed the program, which combined simulation with mental skills training. The goal was to see if skills learned in the simulator could improve d…

This study tested whether a gentle brain stimulation technique called tDCS can make trauma-focused therapy work better for people with PTSD. 63 adults with chronic PTSD received either real or fake tDCS during therapy sessions. The goal was to see if the combination could reduce …

This study looked at whether smartphone data—like activity, sleep, and social patterns—could help track symptoms in 87 veterans with serious mental illnesses such as schizophrenia, bipolar disorder, or PTSD. Participants used an app that passively collected this data. The goal wa…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study looked at whether a special advance care planning tool (called POST) helps older adults get the medical care they want at the end of life. Researchers worked with 389 people aged 65 and older, including those with dementia. They checked if the care people received matc…

This study looked at how cannabinoids influence fear signals, emotions, and brain activity in people with PTSD. Researchers measured brain scans and fear responses in 86 participants to understand the link between cannabinoids and PTSD. The goal was to gather knowledge that could…

This study looked at 460 adults who came to the emergency room after a traumatic event, like a serious injury or threat of death. Researchers wanted to find out which factors—biological, psychological, and social—could predict who would develop post-traumatic stress disorder (PTS…

This study looked at whether adding social support (like help with jobs and finances) to standard mental health treatment helps refugees with PTSD function better. About 200 unemployed refugees took part. The goal was to see if working closely with local social services improves …

This study tested a single dose of methylone in 40 healthy adults aged 25 to 55. Researchers measured how much of the drug got into the blood and how long it stayed, and watched for side effects. The goal was to gather safety information, not to treat PTSD directly.

This study looked at whether a non-invasive brain stimulation technique called TMS can improve PTSD symptoms and change related brain activity and stress responses. Researchers worked with 63 adults who had partial PTSD to see if the treatment was feasible and effective. The goal…

This study looked at how a type of talk therapy called mindfulness-based cognitive therapy (MBCT) changes brain activity in people with posttraumatic stress disorder (PTSD). 61 adults with PTSD received either MBCT or a comparison mind-body therapy. Researchers used brain scans t…

This study created and tested a mobile app called VetEd for student veterans who have mental health conditions like depression, PTSD, or anxiety. The app provides academic skills, mental health management, and information on resources. 13 veterans helped researchers improve the a…

This study looked at how negative emotions and stress influence alcohol cravings and drinking behavior in women veterans, including those with PTSD. Researchers also examined whether emotion regulation techniques and menstrual cycle hormones change these effects. The goal was to …

This study looked at whether a free mobile app called BounceBack Now can help people with post-traumatic stress disorder (PTSD) in a primary care setting. Researchers worked with 29 adults, including patients and healthcare providers, to see if the app was easy to use and helpful…

This study followed 14 people who called a crisis hotline after terrorist attacks in Paris, London, Barcelona, and Strasbourg. Researchers wanted to see how their psychiatric symptoms, like post-traumatic stress disorder and major depression, changed over time. The goal was to le…

This study looked at 300 adults to better understand the specific symptoms of complex post-traumatic stress disorder (PTSD), such as dissociation and emotional regulation problems. Participants filled out questionnaires about their experiences. The goal was to improve diagnosis a…

This study looked at how people with post-traumatic stress disorder (PTSD) predict their emotional reactions to future events. Researchers compared 97 adults with and without PTSD to see if those with PTSD tend to expect more intense negative emotions than they actually experienc…

This study looked at how the brain controls unwanted memories in people who lived through the 2015 Paris terrorist attacks. Researchers used brain scans to compare survivors with and without PTSD to healthy people not exposed to the attacks. The goal was to understand why some pe…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study looked at a program called KEEP that trains foster and kinship parents to better support children in their care. The goal was to see if the program could reduce depression, anxiety, PTSD, self-harm, and behavior problems in youth from Native, Hispanic, Black, and LGBTQ…