Veterans' PTSD and opioid relapse: could a two-drug combo offer better relief?
NCT ID NCT04360681
First seen May 09, 2026 · Last updated May 23, 2026 · Updated 4 times
Summary
This study looked at whether adding lofexidine to the standard opioid-use treatment buprenorphine could improve symptoms of both PTSD and opioid use disorder in veterans. 84 veterans on a stable dose of buprenorphine were given either lofexidine or a placebo. The goal was to see if the combination reduced opioid use and PTSD symptoms more than buprenorphine alone.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Michael E. DeBakey Veterans Affairs Medical Center
Houston, Texas, 77030, United States
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South Texas Veterans Health Care System
San Antonio, Texas, 78229, United States
Conditions
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