Can a different type of talk therapy help PTSD as well as standard treatments?
NCT ID NCT00739765
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether interpersonal psychotherapy (IPT) works as well as two established treatments for chronic post-traumatic stress disorder (PTSD): prolonged exposure therapy and relaxation therapy. 110 adults with chronic PTSD took part, receiving weekly sessions over 14 weeks. The goal was to see if IPT, which focuses on improving relationships and social support, could be a good alternative for people who may not tolerate exposure-based therapies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- psychotherapy (interpersonal psychotherapy, prolonged exposure therapy, relaxation therapy)
- What this could lead to
- If successful, this could show that interpersonal psychotherapy is another effective option for treating chronic PTSD, expanding access to care.
- What could go wrong
- This is a completed trial with 110 participants, so results are limited in size. Psychotherapy outcomes can vary widely between individuals, and the study may not prove one therapy is clearly better than others.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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110 people
The number who actually took part.
- Start date
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Apr 2008
- Finished
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Mar 2014
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Meets DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) criteria for primary, chronic PTSD * At least moderately severe symptoms, defined by a minimum total (frequency plus severity) Clinician-Administered PTSD Scale score greater than 50 * Willing to undergo an independent clinical assessment and other ratings Exclusion Criteria: * Diagnosis of schizophrenia, bipolar disorder, or other psychotic disorders * Psychiatric disorder due to a general medical condition * Current substance abuse or dependence * Acute suicide or homicide risk * Unstable or life-threatening medical condition * Primary diagnosis of borderline personality disorder, major depressive disorder, or major depression, melancholic subtype * Diagnosis of antisocial personality disorder * At least partial benefit from current treatment regimen * Unwillingness to discontinue current ineffective psycho- or pharmacotherapy * Inability to speak or read English
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
New York State Psychiatric Institute
New York, New York, 10032, United States
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