POST-TRAUMATIC STRESS DISORDER

This study compares two sedatives—dexmedetomidine and midazolam—in children on breathing machines to see which one reduces delirium (a type of brain dysfunction) and improves recovery. About 372 children aged up to 11 years will take part. The goal is to find a safer sedation met…

This study tests whether a special breathing exercise called cardiac coherence can stop chronic post-traumatic stress disorder (PTSD) from developing. People who recently experienced a traumatic event and have acute stress will practice this breathing technique. The goal is to se…

This study tests whether an online, therapist-guided program called CIPE can prevent PTSD in people who recently experienced a traumatic event. About 360 adults receiving crisis support will either get the online therapy plus usual care, or usual care alone. The goal is to see if…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical and mental health in women veterans aged 18-45. Participants will play VR games that involve physical movement, and researchers will measure changes in depression, anxiety, PTSD, …

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and complete assessments before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves bo…

This study tests whether adding a non-invasive brain stimulation technique (rTMS) to a short writing therapy helps veterans with PTSD feel better. About 98 veterans will receive either real or fake rTMS before their therapy sessions. The goal is to see if the combination reduces …

This study tests whether a 5-day intensive exposure therapy works better than the usual 15-week program for adults with PTSD. About 140 participants will be randomly assigned to either the fast or standard treatment. Researchers will measure symptom changes, costs, and therapist …

This study tests a new drug called TSND-201 to see if it can safely reduce PTSD symptoms in adults. About 300 people will receive one of two doses of the drug or a placebo once a week for 4 weeks, then be followed for 8 more weeks. The goal is to measure changes in PTSD severity …

This study tests whether cannabidiol (CBD) can reduce PTSD symptoms and improve thinking in 120 adults with PTSD, half of whom also have a mild traumatic brain injury. Participants take either 400 mg, 800 mg of CBD, or a placebo daily for 8 weeks. The goal is to see if CBD helps …

This study tests whether a single dose of MDMA, given alongside two weeks of intensive exposure therapy, can help adults with PTSD feel better faster and longer. About 200 participants will receive either MDMA or a placebo during therapy. The main goal is to see if the combinatio…

This study tests a new therapy called the Reconsolidation of Traumatic Memories (RTM) Protocol for people with PTSD in Ukraine. The goal is to reduce distressing symptoms like flashbacks and anxiety in just a few sessions, without requiring patients to relive their trauma. The st…

This study compares two programs to help female Veterans who have experienced military sexual trauma, intimate partner violence, and brain injury. The goal is to improve their ability to manage emotions and reduce PTSD symptoms. About 136 women will take part in the research.

This study tests a stepped approach to help people with PTSD get the right treatment faster. Participants first try a digital mental health program, then may receive brief therapy if needed. The goal is to improve access, engagement, and symptom relief in routine care.

This study tests a noninvasive, personalized brain stimulation treatment (TMS) for people aged 18-65 with chronic symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will have a 66% chance of receiving active TMS and …

This study tests whether adding augmented reality (AR) to standard exposure therapy helps U.S. military personnel with PTSD feel better. Forty veterans or active-duty members will be split into two groups: one gets AR-enhanced therapy, the other gets therapy alone. Researchers wi…

This study tests whether sitting in front of a bright light for 60 minutes each morning can improve sleep in veterans who have had a traumatic brain injury (TBI) and may also have PTSD. About 200 veterans will wear a sleep tracker and fill out questionnaires before, during, and a…

This study tests whether involving a romantic partner in PTSD therapy helps veterans feel better and function in daily life more than standard therapy alone. About 420 post-9/11 veterans in committed relationships will receive either partner-assisted or individual therapy. The go…

This study tests a trauma-informed digital program designed to improve health and safety for immigrant women who have experienced violence and have symptoms of PTSD or depression. Researchers will measure changes in stress, depression, PTSD, self-protection behaviors, and empower…

This study tests a new training program for 20 veterans who have both mild traumatic brain injury (mTBI) and PTSD and struggle to recognize emotions in faces and voices. The program combines emotion recognition practice with attention training to help them better understand other…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face depression, anxiety, and PTSD, but mental health care is hard to access. The app aims to reduce these symptoms and improve quality of…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce PTSD symptoms in women who experienced sexual assault. About 70 women will receive the treatment in a supervised setting. The goal is to see if this approac…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in 128 adults with anxiety, depression, or PTSD. Participants are randomly assigned to either the active training or a sham version. The goal is to see if th…

This study tests whether trauma-focused therapy delivered via video calls is practical and acceptable for adults with PTSD or complex PTSD. Researchers will enroll 13 people from community mental health services in Chile. The goal is to see if this approach works well and helps r…

This study tests whether having a dream while under anesthesia can reduce symptoms of PTSD. About 42 adults with PTSD will be randomly assigned to either deep sedation (to encourage dreaming) or light sedation (to avoid dreams). Researchers will compare changes in PTSD symptoms b…

This study tests whether MDMA-assisted therapy can help veterans who have both PTSD and alcohol use disorder. About 80 veterans will receive either MDMA or a low-dose placebo during three therapy sessions. The goal is to see if this approach reduces PTSD symptoms and drinking.

This study tests several new medications for PTSD in 800 active-duty service members and veterans aged 18 to 64. Participants are randomly assigned to receive either a study drug or a placebo (a pill with no active medicine). The main goal is to see if the drugs reduce PTSD sympt…

This study tests whether a lavender oil capsule called Silexan can reduce PTSD symptoms in adults. About 278 people with PTSD will take either Silexan or a placebo daily for 12 weeks, along with their usual treatments. Researchers will compare symptom changes using a standard PTS…

This study tests a medicine called BXCL501 (a fast-dissolving film placed under the tongue) to see if it can reduce severe stress symptoms and prevent PTSD in people who have just been in a car accident. About 100 adults who come to the emergency room within 72 hours of a crash w…

This study looks at whether treating sleep apnea early can improve long-term outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive sleep apnea treatment right away or be placed on a waitlist. The…

This study tests a technique called heart rate variability biofeedback, which uses breathing exercises to help people with long-lasting symptoms after a mild concussion. The goal is to reduce issues like headaches, dizziness, memory problems, and mood changes. The trial includes …

This small study tests whether a sleep-focused therapy delivered by video call can help prevent PTSD and depression in people who recently had a car accident. About 20 adults at high risk for PTSD will be enrolled within 72 hours of their crash. The goal is to see if the therapy …

This study is testing a digital therapeutic app called OTX-601 to see if it can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. About 40 people with PTSD will use the app, and researchers will track changes in their symptoms over 27 weeks. The goal is to find …

This study tests whether a sleep medication called daridorexant can help reduce PTSD symptoms in 200 active-duty service members and veterans. Participants will receive either the drug or a placebo, and researchers will track changes in PTSD severity and safety over 12 weeks. The…

This study is testing whether a specific type of acupuncture can help reduce symptoms of post-traumatic stress disorder (PTSD) in 75 active-duty military members and their families. Participants will receive acupuncture and be monitored using standard PTSD questionnaires and bloo…

This study tests whether a single IV dose of allopregnanolone (a natural brain chemical) can help people with chronic PTSD get more out of therapy. The drug may help the brain better process traumatic memories by either strengthening new learning or weakening old fear responses. …

This study tests a non-trauma psychotherapy for military veterans and service members who have both PTSD and a mild or moderate traumatic brain injury (TBI). The treatment involves individual talk therapy sessions to help manage PTSD symptoms. The study will enroll 30 participant…

This study looks at how a stay in the intensive care unit (ICU) affects a person's quality of life after leaving the hospital. Researchers want to understand if having no memory of the ICU stay leads to post-traumatic stress disorder (PTSD). They will ask 40 adults who stayed in …

This study looks at why people with PTSD often have higher heart disease risk. Researchers will test two daily therapies—deep breathing exercises and a mild nerve-stimulating device—to see if they can calm an overactive nervous system. About 120 veterans with or without PTSD and …

This study explores a non-invasive way to weaken fear memories soon after a traumatic event, potentially lowering the risk of developing PTSD. Researchers will use brain imaging and mild sensory stimulation in 66 adults (some with PTSD) to see if they can disrupt how the brain st…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study aims to see if a carbon dioxide (CO2) challenge can help doctors identify patients with anxiety, OCD, PTSD, or panic disorder who are unlikely to improve with exposure-based therapy. Researchers will enroll 600 adults aged 18-70 and measure their response to CO2 before…

This study aims to see if a new technology combining brain stimulation (TMS) with brain imaging (fNIRS) can directly measure brain activity to personalize treatment dosing for people with PTSD, with or without mild traumatic brain injury. About 60 adults aged 18-70 who are eligib…

This study aims to understand how teenagers with post-traumatic stress disorder (PTSD) experience changes during psychotherapy. Researchers will interview 65 teens aged 12-18, along with their parents and therapists, to learn what helps them heal. The goal is to improve therapy b…

This study looks at why young women with post-traumatic stress disorder (PTSD) may have a higher risk of heart disease later in life. Researchers will test if drinking beetroot juice can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal…

This study looks at how U.S. combat veterans with PTSD react to very brief images of combat compared to healthy controls. Participants will view these images during a brain scan and rate their fear. The goal is to understand brain activity and awareness, not to provide treatment.

This study looks at whether a computer-based working memory training program can help veterans with PTSD better learn to unlearn fear. The training aims to improve the brain's ability to hold and use information, which may make fear extinction (a key part of PTSD recovery) more e…

This study looks at how sleep and emotions are connected in teenagers with post-traumatic stress disorder (PTSD). Researchers want to see if improving sleep quality can help teens feel better the next day. About 180 teens aged 15-18 will take part in sleep studies, surveys, and b…

This study looks at how to help veterans with PTSD who are struggling with a common therapy called Cognitive Processing Therapy (CPT). Researchers want to see if switching to a different therapy or sticking with CPT works better. They will also test two ways to identify when some…

This study looks at how prolonged exposure therapy helps people with PTSD. Researchers will measure brain activity, stress responses, and symptoms before, during, and after 10 therapy sessions. The goal is to understand why the therapy works and who benefits most. 50 adults with …

This study looks at how having PTSD might change the way people make decisions after drinking alcohol. Researchers want to understand why some people with PTSD develop alcohol problems. They will give 200 adults either alcohol or a placebo and use brain scans to see how their bra…