Could lavender oil ease PTSD? new trial aims to find out
NCT ID NCT06412757
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether Silexan, a lavender oil extract available over-the-counter, can reduce PTSD symptoms in adults. 278 participants will take Silexan or a placebo daily for 12 weeks alongside their usual treatments. The goal is to see if this well-tolerated supplement offers a new option for those who struggle with current therapies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Silexan (lavender oil extract)
- What this could lead to
- If it works, this could provide a well-tolerated, over-the-counter option to ease PTSD symptoms for adults.
- What could go wrong
- This is a Phase 3 trial, but previous evidence is limited to a small pilot study. The effect may be small or no better than placebo. Mild side effects like burping or breath odour are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 278 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2024
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged 18 years or over. 2. Fluent in English. 3. Meet DSM-5 criteria for PTSD, irrespective of occupation (e.g. first responder, police officer, ex-military or civilian), determined using the Mini International Neuropsychiatric Interview 7.0.2. 4. Have a score on the PTSD Checklist for DSM-5 (PCL-5) equal to or over 33. Exclusion Criteria: 1. Are currently serving in the Australian Defence Force 2. Lifetime history of a psychotic or bipolar disorder, or dissociative identity disorder. 3. Moderate or severe alcohol or other substance use disorder within 3 months of screening. 4. Active suicidal or homicidal ideation. 5. Borderline Personality Disorder (BPD). 6. Acute or unstable medical illness or other significant medical condition, that would make participation in the trial unsafe or inappropriate. 7. Pregnancy, lactation or unwillingness to use an acceptable method of contraception (required for both males and females who are of reproductive potential and sexually active with partners of the opposite sex) through the duration of participants' involvement in the study up to and including week 16. Participants will also be advised not to donate eggs or sperm during the study period. 8. Commencement of a trauma-focussed psychotherapy (including Prolonged Exposure, Cognitive Processing Therapy and Eye Movement Desensitisation and Reprocessing) within 3 months of screening. 9. Commencement or change in dose of psychoactive medications within 4 weeks of screening. 10. Participants will be asked not to initiate psychotherapy or change the dose of psychoactive medications during the course of the study except in clinically urgent circumstances; if this becomes necessary, a decision will be made on a case-by-case basis with regard to retaining the participant or terminating their participation. 11. Severe acquired brain injury. 12. Individual is not eligible for public mental health services due to their visa status in Australia or for any other reason. 13. Any other condition that in the opinion of the research team is likely to make completion of the trial requirements infeasible. 14. Inability to understand or speak English to the extent necessary to give informed consent and complete the trial (researcher or clinician-determined).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Austin Health
RECRUITINGHeidelberg, Victoria, 3084, Australia
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Deakin University
RECRUITINGGeelong, Victoria, 3220, Australia
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Ramsay Clinic Albert Road
RECRUITINGMelbourne, Victoria, 3004, Australia
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University of Melbourne
RECRUITINGCarlton, Victoria, 5053, Australia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Five sessions to quiet trauma nightmares in bipolar disorder
- Can training hospital staff in Trauma-Informed care make childbirth safer?
- Scientists probe brain's reward system in mental illness
- Can a mindfulness class help veterans with concussion and PTSD?
- Can MDMA plus therapy help veterans fight both PTSD and alcohol addiction?
- Can talk therapies quiet the trauma of violence?