POST TRAUMATIC STRESS DISORDER

This pilot study explores whether a breathing technique called cardiac coherence can help prevent chronic post-traumatic stress disorder (PTSD) in people who recently experienced a traumatic event. The study will enroll 44 adults with acute stress disorder, teaching them a slow, …

This study tests whether a new drug called TSND-201 can safely reduce PTSD symptoms in adults. About 300 people with PTSD will receive either one of two doses of the drug or a placebo once a week for 4 weeks, then be followed for 8 more weeks. The goal is to see if the drug helps…

This study compares two programs designed to help female Veterans who have experienced military sexual trauma or intimate partner violence and also have a history of brain injury. The goal is to see which program works better at improving emotional control and reducing PTSD sympt…

This study tests whether adding augmented reality (AR) to standard exposure therapy helps U.S. military personnel with PTSD feel better. Forty veterans or active-duty members will be split into two groups: one gets AR-enhanced therapy, the other gets therapy alone. Researchers wi…

This study tests several new medications to see if they can reduce PTSD symptoms in active-duty service members and veterans. About 800 people aged 18 to 65 with PTSD will be randomly assigned to receive either a study drug or a placebo (a pill with no active medicine). The main …

This study tests whether MDMA, combined with a specific type of talk therapy, can help reduce PTSD symptoms in veterans. Twenty veterans with PTSD will receive different doses of MDMA during therapy sessions. The goal is to see if this approach lowers PTSD severity as measured by…

This study tests whether fluoxetine, a standard antidepressant, can reduce PTSD symptoms in 200 active-duty service members and veterans. Participants receive either the drug or a placebo, and researchers track changes in symptom severity and safety over 12 weeks. The goal is to …

This study is testing whether a specific type of acupuncture can reduce symptoms of post-traumatic stress disorder (PTSD) in 75 active-duty military members and their families. Participants will receive acupuncture and be monitored using standard PTSD questionnaires and blood tes…

This study tests a digital program designed to help immigrant women who have experienced violence and struggle with PTSD or depression. The program focuses on reducing stress, improving safety, and building self-care habits. Researchers will track changes in stress, mood, and pro…

This study tests whether bringing a romantic partner into PTSD therapy helps veterans function better in daily life. About 420 post-9/11 veterans in committed relationships will receive either standard therapy or partner-assisted therapy. The goal is to improve relationships, wor…

This study tests whether having a dream while under anesthesia can reduce symptoms of PTSD. About 42 adults with PTSD will be randomly assigned to either deep sedation (to encourage dreaming) or light sedation (to avoid dreaming). Researchers will compare changes in PTSD severity…

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and complete assessments before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves bo…

This study tests whether a digital therapeutic app called OTX-601 can help reduce symptoms of posttraumatic stress disorder (PTSD) in adults. Researchers will measure changes in PTSD symptoms over 27 weeks in 40 participants who have a PTSD diagnosis and use a smartphone. The goa…

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD and struggle to recognize emotions in others. The program combines face and voice emotion training with attention exercises. Researchers hope this will improve veterans'…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors struggle with anxiety, depression, and PTSD, but mental health care is hard to access. The app is designed to be used at home, and researc…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults aged 21-55 will be randomly assigned to either the active training or a sham version. The goal is to …

This study explores whether a non-invasive brain technique can disrupt the way fear memories are stored after a traumatic event. Researchers will work with 66 adults, some with PTSD, using brain scans and mild stimulation to see if they can weaken fear responses. The goal is to f…

This study looks at how U.S. combat veterans with PTSD react to very brief images of combat scenes. About 80 veterans and healthy volunteers will have their brains scanned while viewing these images and rating their fear. The goal is to understand brain activity and awareness, no…

This study looks at how Prolonged Exposure therapy helps people with PTSD by tracking changes in the brain, body, and feelings before, during, and after treatment. Researchers will work with 50 adults who have PTSD and want to try this therapy. The goal is to find out what makes …

This study looks at why people with PTSD often have higher heart disease risk. Researchers will test two daily therapies—a breathing device and a nerve-stimulating device—to see if they calm the overactive nervous system. About 120 veterans with or without PTSD and slightly high …

This study is testing whether a simple carbon dioxide (CO2) breathing challenge can help doctors predict which patients with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults aged 18-70 and measure their response …

This study tests a new way to personalize brain stimulation treatment for people with PTSD, with or without mild traumatic brain injury. Researchers will use a special device that combines magnetic stimulation and light-based brain imaging to measure brain activity directly. The …

This study looks at why women with PTSD have higher heart disease risk as they age. Researchers will test if beetroot juice, which is rich in nitric oxide, can improve blood vessel function in 30 premenopausal women with trauma exposure. The goal is to understand the link between…

This study looks at whether a computer-based working memory training program can help veterans with PTSD learn to overcome fear. About 120 veterans will do memory exercises or a sham version for 4 weeks, then have brain scans and fear tests. The goal is to see if the training cha…

This study uses PET brain scans to measure cannabinoid receptors in healthy volunteers and people with conditions like schizophrenia, cannabis dependence, PTSD, and opioid use disorder. Researchers want to understand how these receptors differ across groups and how they change wi…