Flash therapy: could subliminal combat images ease PTSD?
NCT ID NCT06218381
First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 3 times
Summary
This study explores whether showing combat veterans with PTSD very brief, barely visible images of combat scenes can change their brain activity and reduce fear. Participants will view these images during an fMRI brain scan and rate their fear. The goal is to understand how the brain responds to this type of exposure, not yet to treat PTSD. The study compares veterans with PTSD to healthy controls.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Very Brief Exposure to combat images (a behavioral procedure using subliminal picture flashes)
- What this could lead to
- If successful, this could point toward a new, non-drug treatment for PTSD that is easier to tolerate than traditional exposure therapy.
- What could go wrong
- This is an early, small study (80 people) focused on brain activity and fear ratings, not on curing PTSD. It may not lead to a practical treatment, and results may not apply to all veterans.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2024
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patient Population * Males and females ages 18-50 * Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) diagnosis of PTSD * Traumatic event is a combat-based experience (e.g., being injured, watching a buddy be killed) * Minimum score of 18 on the Combat Experience Scale (CES) * Minimum score of 3 or more on Primary Care (PC)-PTSD-5 * Participants with other cooccurring psychiatric disorders (e.g., anxiety, ADHD) will be included to ensure a representative sample. Healthy Population • Males and Females, ages 18-50 Exclusion Criteria: Patient Population * Treatment for PTSD, substance abuse, or mental health concerns in the past 6 months * 10 or more years since the combat trauma * Acute intoxication * Severe level of Substance Dependence (6 or more DSM-V symptoms) * Prior diagnosis of Autistic Spectrum Disorders * Current or past psychotic disorders or active psychotic symptoms * Current Bipolar I Disorder * Dementia * Neurological or serious medical conditions (e.g., stroke, epilepsy/ seizure disorder, cancer, Lupus, HIV+); * Traumatic brain injury Healthy Population * Ferromagnetic implants (e.g., pacemaker), metal braces, retainers, tattoos or permanent make up w/ metallic content, transdermal medicinal patches that cannot be removed * Neurological or serious medical conditions (e.g., stroke, epilepsy/ seizure disorder, cancer, Lupus, HIV+); * Lifetime Diagnosis of PTSD, Tourette's Syndrome, Bipolar Disorder, Substance Dependence, Eating Disorder, Autism Spectrum Disorder, a psychotic disorder, Acute Stress Disorder * Lifetime history of traumatic event defined as a life-threatening event involving physical attack, guns, fire or explosion (i.e the kinds of traumatic events combat veterans are likely to experience) * Traumatic Brain Injury * Birth at less than 37 weeks gestational age * Claustrophobia * Anxiety Disorder, Mood Disorder, Substance Abuse Disorder, Adjustment Disorder in past 2 years * Treatment for mental health concern in past 2 years * Pregnant Females
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Brain Imaging Lab
RECRUITINGLos Angeles, California, 90027, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Five sessions to quiet trauma nightmares in bipolar disorder
- Can training hospital staff in Trauma-Informed care make childbirth safer?
- Scientists probe brain's reward system in mental illness
- Can a mindfulness class help veterans with concussion and PTSD?
- Can MDMA plus therapy help veterans fight both PTSD and alcohol addiction?
- Can talk therapies quiet the trauma of violence?