Children's Hospital Los Angeles

This study tests whether butyrate enemas can help Hispanic children aged 7-21 with mild-to-moderate ulcerative colitis. Butyrate is a natural substance made by gut bacteria that may reduce inflammation. The goal is to see if it can lower disease activity scores and improve marker…

This study tests whether a 4-week online education program about continuous glucose monitors (CGMs) helps youth aged 8-21 with type 2 diabetes improve their blood sugar control compared to standard care. Participants will attend virtual sessions with a diabetes educator and use t…

This study tests a 10-week group intervention called Bridge the Gap, designed specifically for Black youth aged 12-17 who are having suicidal thoughts. The program adapts an existing suicide prevention model to be more culturally relevant. Researchers want to see if the group is …

This study tests two school-based sleep programs in 1,320 teens aged 12-18 with sleep problems. One program is a standard sleep health education, the other is a more intensive cognitive behavioral sleep intervention. Researchers will compare which program improves sleep quality m…

This study tests whether shared medical appointments—where teens with type 2 diabetes meet their doctor in a group setting with educational activities—are a good way to deliver care. 160 teens aged 12-18 will either receive standard care or attend quarterly group clinics. Researc…

This study tests whether a virtual education program called CGM Academy can help youth (ages 8-18) with type 1 diabetes improve their blood sugar levels. Participants will receive an interactive workbook and four online group sessions with diabetes educators. The study will compa…

This study tests whether using a virtual reality headset during interventional radiology procedures can lower pain and anxiety in children aged 8 and older. About 500 participants will use the VR headset or receive standard care, and researchers will compare their pain and anxiet…

This pilot study tests whether Maralixibat, a drug that increases bile acids in the colon, can improve stool consistency in 20 children with cystic fibrosis who have chronic constipation. Participants will take the drug for two weeks alongside their usual laxatives. The goal is t…

This study tests whether a sleep-focused therapy can improve depression in teenagers whose body clocks are out of sync with their wake-up time. Researchers will enroll 200 adolescents with depression and delayed sleep phase. The therapy aims to realign their internal circadian rh…

This study is testing a 10-session group therapy called Acceptance and Commitment Therapy (ACT) for Black teens and young adults (ages 14-21) with sickle cell disease. The goal is to help them cope with race-related stress, reduce depression and anxiety, and improve their quality…

This study tests if short, social-media-style health videos can help teens with chronic illnesses feel more confident and prepared to manage their own healthcare as they grow up. About 44 teens aged 12-17 will be randomly assigned to watch these videos or use standard health webs…

This study creates a research database of 5,000 childhood cancer survivors treated at Children's Hospital Los Angeles. By collecting health information from follow-up visits, researchers aim to identify risk factors for late effects—complications that can appear years after treat…

This study is testing a computer program that helps doctors make better decisions about ventilator settings for children with severe lung injury (PARDS). The tool is based on the best available evidence and aims to reduce differences in care between hospitals. Up to 180 children …

This study collects medical information and fluid from the front of the eye (aqueous humor) from up to 800 children with retinoblastoma, a rare eye cancer. Researchers aim to find biological markers in the fluid that can predict whether the eye can be saved with treatment. The st…

This pilot study is testing a mobile health program designed to help adolescents and young adults (ages 15-20) with chronic health conditions remember to take their daily oral medications. Researchers want to see if the program is easy to use and if it improves medication adheren…

This study looks at how U.S. combat veterans with PTSD react to very brief images of combat scenes. Participants will view these images during a brain scan and rate their fear. The goal is to understand brain activity and awareness, not to treat PTSD. Healthy controls are also in…

This study looks at how the brains of young people aged 16-22 with social anxiety disorder react to very brief glimpses of facial expressions. Researchers will use brain scans to measure activity in areas linked to emotion and attention. The goal is to gather information that cou…

This pilot study tests a simple idea: giving African American children ages 2-4 self-esteem themed books and advice during regular doctor visits. Researchers want to see if this helps parents reinforce positive self-concept and improves children's behavior and early reading skill…