Brain zaps and pen to paper: new PTSD therapy for veterans?
NCT ID NCT05149534
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding a noninvasive brain stimulation technique called rTMS to a brief writing therapy (WET) can better reduce PTSD symptoms in veterans. About 98 veterans with PTSD will receive either real or fake rTMS before their writing sessions. Researchers will measure changes in PTSD severity and emotional flexibility to see if the combination works better than therapy alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS) and written exposure therapy (WET)
- What this could lead to
- If it works, this could offer a more effective, shorter PTSD treatment for veterans by combining brain stimulation with a brief therapy.
- What could go wrong
- This is an early-stage study with only 98 participants, and the sham group may also improve. rTMS can cause mild side effects like headache or scalp discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 98 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2022
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: -All veterans are eligible to be included in the study if they meet all the following criteria: * veteran; * English-speaking and able to provide written informed consent; * diagnosed with PTSD; * between the ages of 18 and 60 years. Participants over age 60 will not be included, as aging is known to impact brain structure, and thus the potential accuracy of the rTMS target, independently of PTSD. Exclusion Criteria: * Individuals with history of seizures or other serious neurological history including acquired, developmental or degenerative neurologic illness, identified through medical chart review, will be excluded due to potential lowered threshold for seizures during rTMS stimulation. * The effects of rTMS are unknown on fetal development, therefore, women who are pregnant will be excluded. * Participants will also be screened and excluded if any of the following are met: * current psychosis including psychotic disorder, * bipolar disorder, * schizophrenia; or another severe cognitive or psychiatric disorder; * positive screen for current suicidal intent and plan \[with a score of 2 or 3 on BDI-2 item 9\]; * current substance use disorder; or substance use in the last 12 hours before the rTMS session. * The investigators note that PTSD is often comorbid with traumatic brain injury (TBI) in military veterans who were deployed to a war zone. The investigators will use the Department of Defense and Veterans Affairs consensus-based classification of TBI severity for classification of TBI. * Participants with moderate or severe TBI will be excluded. * Participants with mild traumatic brain injury (mTBI) or concussion will be enrolled. This will enhance the ecological validity of the study. * Participants with cognitive impairment as evidenced by a Montreal Cognitive Screen (MoCA) less than 23/30 or estimated baseline intellectual ability of a standard score of less than 80 on a word reading test will be excluded due to potential neurocognitive differences. * Participants on psychotropic medications will not be excluded, but participants will be required to be stable on their medication for at least four weeks prior to beginning the study and throughout the time of study. * Participants enrolled in long term, supportive psychotherapy (i.e. not an evidence-based psychotherapy (EBP)) may continue to be involved in their treatment throughout the study. However, participants involved in a concurrent EBPs will be excluded. Participants will be asked to disclose whether they chose to participate in an EBP during the course of the treatment or followup phases of the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Central Texas Veterans Health Care System, Temple, TX
RECRUITINGTemple, Texas, 76504-7451, United States
More trials for these conditions
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- Scientists probe brain's reward system in mental illness
- Can a mindfulness class help veterans with concussion and PTSD?
- Can MDMA plus therapy help veterans fight both PTSD and alcohol addiction?
- Can talk therapies quiet the trauma of violence?